Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200596001> ?p ?o ?g. }
- W4200596001 endingPage "44" @default.
- W4200596001 startingPage "25" @default.
- W4200596001 abstract "Amyotrophic Lateral Sclerosis (ALS) is a fatal disease, progressive nature characterizes by loss of both upper and lower motor neuron functions. One of the major challenge is to understand the mechanism of ALS multifactorial nature. We aimed to explore some key genes related to ALS through bioinformatics methods for its therapeutic intervention. Here, we applied a systems biology approach involving experimentally validated 148 ALS-associated proteins and construct ALS protein-protein interaction network (ALS-PPIN). The network was further statistically analysed and identified bottleneck-hubs. The network is also subjected to identify modules which could have similar functions. The interaction between the modules and bottleneck-hubs provides the functional regulatory role of the ALS mechanism. The ALS-PPIN demonstrated a hierarchical scale-free nature. We identified 17 bottleneck-hubs, in which CDC5L, SNW1, TP53, SOD1, and VCP were the high degree nodes (hubs) in ALS-PPIN. CDC5L was found to control highly cluster modules and play a vital role in the stability of the overall network followed by SNW1, TP53, SOD1, and VCP. HSPA5 and HSPA8 acting as a common connector for CDC5L and TP53 bottleneck-hubs. The functional and disease association analysis showed ALS has a strong correlation with mRNA processing, protein deubiquitination, and neoplasms, nervous system, immune system disease classes. In the future, biochemical investigation of the observed bottleneck-hubs and their interacting partners could provide a further understanding of their role in the pathophysiology of ALS." @default.
- W4200596001 created "2021-12-31" @default.
- W4200596001 creator A5020470012 @default.
- W4200596001 creator A5089281504 @default.
- W4200596001 date "2022-06-01" @default.
- W4200596001 modified "2023-10-18" @default.
- W4200596001 title "Protein network analysis to prioritize key genes in amyotrophic lateral sclerosis" @default.
- W4200596001 cites W1510727954 @default.
- W4200596001 cites W1964716329 @default.
- W4200596001 cites W1973195184 @default.
- W4200596001 cites W1973912326 @default.
- W4200596001 cites W1974448552 @default.
- W4200596001 cites W1975403755 @default.
- W4200596001 cites W1978592341 @default.
- W4200596001 cites W1983560493 @default.
- W4200596001 cites W1983633543 @default.
- W4200596001 cites W1985213868 @default.
- W4200596001 cites W1989684700 @default.
- W4200596001 cites W1991660507 @default.
- W4200596001 cites W1995562155 @default.
- W4200596001 cites W2002396510 @default.
- W4200596001 cites W2008213051 @default.
- W4200596001 cites W2009405916 @default.
- W4200596001 cites W2010000580 @default.
- W4200596001 cites W2010545648 @default.
- W4200596001 cites W2016332933 @default.
- W4200596001 cites W2019986404 @default.
- W4200596001 cites W2030640098 @default.
- W4200596001 cites W2037442572 @default.
- W4200596001 cites W2047998870 @default.
- W4200596001 cites W2048813950 @default.
- W4200596001 cites W2050335693 @default.
- W4200596001 cites W2054673335 @default.
- W4200596001 cites W2057498577 @default.
- W4200596001 cites W2059997993 @default.
- W4200596001 cites W2062533676 @default.
- W4200596001 cites W2063851759 @default.
- W4200596001 cites W2065114693 @default.
- W4200596001 cites W2066877344 @default.
- W4200596001 cites W2072981065 @default.
- W4200596001 cites W2073068786 @default.
- W4200596001 cites W2074443723 @default.
- W4200596001 cites W2074562205 @default.
- W4200596001 cites W2076158096 @default.
- W4200596001 cites W2076404202 @default.
- W4200596001 cites W2082101329 @default.
- W4200596001 cites W2082157398 @default.
- W4200596001 cites W2087194317 @default.
- W4200596001 cites W2096386031 @default.
- W4200596001 cites W2101181377 @default.
- W4200596001 cites W2106391842 @default.
- W4200596001 cites W2110184140 @default.
- W4200596001 cites W2120772351 @default.
- W4200596001 cites W2123869107 @default.
- W4200596001 cites W2127405101 @default.
- W4200596001 cites W2130062777 @default.
- W4200596001 cites W2130790725 @default.
- W4200596001 cites W2135607950 @default.
- W4200596001 cites W2136850043 @default.
- W4200596001 cites W2141585940 @default.
- W4200596001 cites W2142798429 @default.
- W4200596001 cites W2142827986 @default.
- W4200596001 cites W2144656637 @default.
- W4200596001 cites W2146046001 @default.
- W4200596001 cites W2150523249 @default.
- W4200596001 cites W2154942446 @default.
- W4200596001 cites W2154945114 @default.
- W4200596001 cites W2155221045 @default.
- W4200596001 cites W2155723007 @default.
- W4200596001 cites W2156054547 @default.
- W4200596001 cites W2163480486 @default.
- W4200596001 cites W2163485494 @default.
- W4200596001 cites W2201354711 @default.
- W4200596001 cites W2340895726 @default.
- W4200596001 cites W2465057958 @default.
- W4200596001 cites W2509479781 @default.
- W4200596001 cites W2557633235 @default.
- W4200596001 cites W2558146294 @default.
- W4200596001 cites W2591544166 @default.
- W4200596001 cites W2597921152 @default.
- W4200596001 cites W2616561032 @default.
- W4200596001 cites W2623645769 @default.
- W4200596001 cites W2736051823 @default.
- W4200596001 cites W2762670842 @default.
- W4200596001 cites W2762922722 @default.
- W4200596001 cites W2766648064 @default.
- W4200596001 cites W2769269450 @default.
- W4200596001 cites W2789717891 @default.
- W4200596001 cites W2798375694 @default.
- W4200596001 cites W2802028464 @default.
- W4200596001 cites W2805217467 @default.
- W4200596001 cites W2887838825 @default.
- W4200596001 cites W2892730226 @default.
- W4200596001 cites W2911237161 @default.
- W4200596001 cites W2911622118 @default.
- W4200596001 cites W2913041247 @default.
- W4200596001 cites W2915705246 @default.
- W4200596001 cites W2918086501 @default.