Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200596822> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W4200596822 abstract "Abstract Imidazo[1,5-α]pyridines are one of the most important groups of N -heterocyclic compounds, with wide applications in pharmaceutics, chemical science and material science. Despite tremendous progress in their synthesis over the past decade, a number of important imidazo[1,5-α]pyridines as intermediate products remain inaccessible, such as 1-alkylimidazo[1,5-α]pyridines. Herein, we report a novel anomeric stereoauxiliary approach for the preparation of this important class of compounds. It strongly expands the scope of readily accessible imidazo[1,5-α]pyridines well beyond the existing state-of-the-art methods. More than 80 products with a substantial number of deemed unattainable ones were synthesized. With the first time accessibility to alkyl(pyridine-2-yl)methanone substrates, a group of important deuterated imidazo[1,5-α]pyridines derivatives were also efficiently achieved. The mechanism containing a key seven-membered ring transition state via α-anomeric stereoauxiliary for this new synthetic pathway is provided in great detail and supported by electronic structure calculations. In total, this novel synthetic approach for a broad range of imidazo[1,5-α]pyridines involving the native stereochemistry will open a new window for research endeavors in diverse fields, encompassing organic synthesis, biomass conversion via cleavage of C-N bonds and medicinal chemistry." @default.
- W4200596822 created "2021-12-31" @default.
- W4200596822 creator A5003850660 @default.
- W4200596822 creator A5019958094 @default.
- W4200596822 creator A5022685547 @default.
- W4200596822 creator A5040501765 @default.
- W4200596822 creator A5047699824 @default.
- W4200596822 creator A5081098041 @default.
- W4200596822 creator A5086870920 @default.
- W4200596822 creator A5087635405 @default.
- W4200596822 date "2021-11-30" @default.
- W4200596822 modified "2023-10-18" @default.
- W4200596822 title "Anomeric stereoauxiliary strategy enables efficient synthesis of wide-ranging imidazo[1,5-α]pyridines" @default.
- W4200596822 doi "https://doi.org/10.21203/rs.3.rs-1088663/v1" @default.
- W4200596822 hasPublicationYear "2021" @default.
- W4200596822 type Work @default.
- W4200596822 citedByCount "0" @default.
- W4200596822 crossrefType "posted-content" @default.
- W4200596822 hasAuthorship W4200596822A5003850660 @default.
- W4200596822 hasAuthorship W4200596822A5019958094 @default.
- W4200596822 hasAuthorship W4200596822A5022685547 @default.
- W4200596822 hasAuthorship W4200596822A5040501765 @default.
- W4200596822 hasAuthorship W4200596822A5047699824 @default.
- W4200596822 hasAuthorship W4200596822A5081098041 @default.
- W4200596822 hasAuthorship W4200596822A5086870920 @default.
- W4200596822 hasAuthorship W4200596822A5087635405 @default.
- W4200596822 hasBestOaLocation W42005968221 @default.
- W4200596822 hasConcept C178790620 @default.
- W4200596822 hasConcept C185592680 @default.
- W4200596822 hasConcept C21951064 @default.
- W4200596822 hasConcept C2779485729 @default.
- W4200596822 hasConcept C2780378348 @default.
- W4200596822 hasConcept C35753019 @default.
- W4200596822 hasConcept C71240020 @default.
- W4200596822 hasConcept C7947691 @default.
- W4200596822 hasConceptScore W4200596822C178790620 @default.
- W4200596822 hasConceptScore W4200596822C185592680 @default.
- W4200596822 hasConceptScore W4200596822C21951064 @default.
- W4200596822 hasConceptScore W4200596822C2779485729 @default.
- W4200596822 hasConceptScore W4200596822C2780378348 @default.
- W4200596822 hasConceptScore W4200596822C35753019 @default.
- W4200596822 hasConceptScore W4200596822C71240020 @default.
- W4200596822 hasConceptScore W4200596822C7947691 @default.
- W4200596822 hasLocation W42005968221 @default.
- W4200596822 hasOpenAccess W4200596822 @default.
- W4200596822 hasPrimaryLocation W42005968221 @default.
- W4200596822 hasRelatedWork W1121511 @default.
- W4200596822 hasRelatedWork W11268281 @default.
- W4200596822 hasRelatedWork W11451327 @default.
- W4200596822 hasRelatedWork W12221288 @default.
- W4200596822 hasRelatedWork W271822 @default.
- W4200596822 hasRelatedWork W4055265 @default.
- W4200596822 hasRelatedWork W4920681 @default.
- W4200596822 hasRelatedWork W4982720 @default.
- W4200596822 hasRelatedWork W7917182 @default.
- W4200596822 hasRelatedWork W8744477 @default.
- W4200596822 isParatext "false" @default.
- W4200596822 isRetracted "false" @default.
- W4200596822 workType "article" @default.