FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200596954> ?p ?o ?g. }

• W4200596954 endingPage "102215" @default.
• W4200596954 startingPage "102215" @default.
• W4200596954 abstract "In mammalian ovaries, oocytes are physically coupled to somatic granulosa cells, and this coupling is crucial for the growth and development of competent oocytes as it mediates the transfer of metabolic support molecules. However, aging-mediated dysregulation in communication between the oocytes and granulosa cells affects the oocyte quality. In the present study, we examined the defected germline-soma communication and reduced mRNA levels encoding key structural components of transzonal projections (TZPs) in maternally aged oocytes. Oral administration of melatonin to aged mice substantially increased TZPs and maintained the cumulus cells-oocyte communication, which played a central role in the production of adequate oocyte ATP levels and reducing the accumulation of reactive oxygen species (ROS), apoptosis, DNA damage, endoplasmic reticulum (ER) stress and spindle/chromosomal defects. This beneficial effect of melatonin was inhibited by carbenoxolone (CBX), a gap junctional uncoupler, which disrupts bidirectional communications between oocyte and somatic cells. Simultaneously, melatonin significantly increased the mRNA and protein levels corresponding to genes associated with TZPs and prevented TZP retraction in in vitro-cultured cumulus-oocyte complex (COCs). Furthermore, we infused melatonin and CBX into the COCs in vitro culture system and monitored the levels of nicotinamide adenine dinucleotide phosphate (NADPH) and glutathione (GSH) in cumulus cells and oocytes. Notably, COCs treated with melatonin demonstrated improved NADPH and GSH levels. Of note, CBX was capable of reducing NADPH and GSH levels, aggravated the ROS accumulation and ER stress. Collectively, our data demonstrate the role of melatonin in preventing age-associated germline-soma communication defects, aiding the relay of antioxidant metabolic molecules for the maintenance of oocyte quality from cumulus cells, which have important potential for improving deficient phenotypes of maternally aged oocytes and the treatment of woman infertility." @default.
• W4200596954 created "2021-12-31" @default.
• W4200596954 creator A5014107789 @default.
• W4200596954 creator A5024712968 @default.
• W4200596954 creator A5037683944 @default.
• W4200596954 creator A5047805337 @default.
• W4200596954 creator A5053657551 @default.
• W4200596954 creator A5055795314 @default.
• W4200596954 creator A5056098090 @default.
• W4200596954 creator A5059082021 @default.
• W4200596954 creator A5066444521 @default.
• W4200596954 creator A5074736274 @default.
• W4200596954 creator A5090889485 @default.
• W4200596954 date "2022-02-01" @default.
• W4200596954 modified "2023-10-13" @default.
• W4200596954 title "Melatonin improves the quality of maternally aged oocytes by maintaining intercellular communication and antioxidant metabolite supply" @default.
• W4200596954 cites W1485256456 @default.
• W4200596954 cites W1495529787 @default.
• W4200596954 cites W1754595315 @default.
• W4200596954 cites W1963832918 @default.
• W4200596954 cites W1968446974 @default.
• W4200596954 cites W1981794598 @default.
• W4200596954 cites W2006938518 @default.
• W4200596954 cites W2017666826 @default.
• W4200596954 cites W2031661979 @default.
• W4200596954 cites W2045481955 @default.
• W4200596954 cites W2050845656 @default.
• W4200596954 cites W2091042682 @default.
• W4200596954 cites W2098134487 @default.
• W4200596954 cites W2101821211 @default.
• W4200596954 cites W2108740480 @default.
• W4200596954 cites W2123760965 @default.
• W4200596954 cites W2133586829 @default.
• W4200596954 cites W2139798695 @default.
• W4200596954 cites W2162917886 @default.
• W4200596954 cites W2180001106 @default.
• W4200596954 cites W2196804939 @default.
• W4200596954 cites W2425881963 @default.
• W4200596954 cites W2587144110 @default.
• W4200596954 cites W2597951742 @default.
• W4200596954 cites W2728715382 @default.
• W4200596954 cites W2790592481 @default.
• W4200596954 cites W2790972191 @default.
• W4200596954 cites W2804054946 @default.
• W4200596954 cites W2909613278 @default.
• W4200596954 cites W2918825869 @default.
• W4200596954 cites W2951475323 @default.
• W4200596954 cites W2964529056 @default.
• W4200596954 cites W2973011115 @default.
• W4200596954 cites W2991083419 @default.
• W4200596954 cites W2992626852 @default.
• W4200596954 cites W2999372282 @default.
• W4200596954 cites W3002962970 @default.
• W4200596954 cites W3004127014 @default.
• W4200596954 cites W3005675840 @default.
• W4200596954 cites W3015541167 @default.
• W4200596954 cites W3028816559 @default.
• W4200596954 cites W3047055630 @default.
• W4200596954 cites W3088781649 @default.
• W4200596954 cites W3091468198 @default.
• W4200596954 cites W3092705594 @default.
• W4200596954 cites W3157357644 @default.
• W4200596954 cites W4245957869 @default.
• W4200596954 doi "https://doi.org/10.1016/j.redox.2021.102215" @default.
• W4200596954 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34929573" @default.
• W4200596954 hasPublicationYear "2022" @default.
• W4200596954 type Work @default.
• W4200596954 citedByCount "30" @default.
• W4200596954 countsByYear W42005969542022 @default.
• W4200596954 countsByYear W42005969542023 @default.
• W4200596954 crossrefType "journal-article" @default.
• W4200596954 hasAuthorship W4200596954A5014107789 @default.
• W4200596954 hasAuthorship W4200596954A5024712968 @default.
• W4200596954 hasAuthorship W4200596954A5037683944 @default.
• W4200596954 hasAuthorship W4200596954A5047805337 @default.
• W4200596954 hasAuthorship W4200596954A5053657551 @default.
• W4200596954 hasAuthorship W4200596954A5055795314 @default.
• W4200596954 hasAuthorship W4200596954A5056098090 @default.
• W4200596954 hasAuthorship W4200596954A5059082021 @default.
• W4200596954 hasAuthorship W4200596954A5066444521 @default.
• W4200596954 hasAuthorship W4200596954A5074736274 @default.
• W4200596954 hasAuthorship W4200596954A5090889485 @default.
• W4200596954 hasBestOaLocation W42005969541 @default.
• W4200596954 hasConcept C104317684 @default.
• W4200596954 hasConcept C126322002 @default.
• W4200596954 hasConcept C134018914 @default.
• W4200596954 hasConcept C134305767 @default.
• W4200596954 hasConcept C158157758 @default.
• W4200596954 hasConcept C158617107 @default.
• W4200596954 hasConcept C196843134 @default.
• W4200596954 hasConcept C2776690073 @default.
• W4200596954 hasConcept C2778182776 @default.
• W4200596954 hasConcept C2780961449 @default.
• W4200596954 hasConcept C55493867 @default.
• W4200596954 hasConcept C71924100 @default.
• W4200596954 hasConcept C79879829 @default.
• W4200596954 hasConcept C86803240 @default.
• W4200596954 hasConcept C95444343 @default.

• next