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- W4200596956 endingPage "13630" @default.
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- W4200596956 abstract "Kirsten rat sarcoma 2 viral oncogene homolog (Kras) is a proto-oncogene that encodes the small GTPase transductor protein KRAS, which has previously been found to promote cytokine secretion, cell survival, and chemotaxis. However, its effects on preadipocyte differentiation and lipid accumulation are unclear. In this study, the effects of KRAS inhibition on proliferation, autophagy, and adipogenic differentiation as well as its potential mechanisms were analyzed in the 3T3-L1 and C2C12 cell lines. The results showed that KRAS was localized mainly in the nuclei of 3T3-L1 and C2C12 cells. Inhibition of KRAS altered mammalian target of rapamycin (Mtor), proliferating cell nuclear antigen (Pcna), Myc, peroxisome proliferator-activated receptor γ (PPARγ), CCAAT/enhancer binding protein beta (C/ebp-β), diacylglycerol O-acyltransferase 1 (Dgat1), and stearoyl-coenzyme A desaturase 1 (Scd1) expression, thereby reducing cell proliferation capacity while inducing autophagy, enhancing differentiation of 3T3-L1 and C2C12 cells into mature adipocytes, and increasing adipogenesis and the capacity to store lipids. Moreover, during differentiation, KRAS inhibition reduced the levels of extracellular regulated protein kinases (ERK), c-Jun N-terminal kinase (JNK), p38, and phosphatidylinositol 3 kinase (PI3K) activation. These results show that KRAS has unique regulatory effects on cell proliferation, autophagy, adipogenic differentiation, and lipid accumulation." @default.
- W4200596956 created "2021-12-31" @default.
- W4200596956 creator A5011459777 @default.
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- W4200596956 creator A5075101600 @default.
- W4200596956 date "2021-12-20" @default.
- W4200596956 modified "2023-10-14" @default.
- W4200596956 title "KRAS Affects Adipogenic Differentiation by Regulating Autophagy and MAPK Activation in 3T3-L1 and C2C12 Cells" @default.
- W4200596956 cites W1547736903 @default.
- W4200596956 cites W1784053566 @default.
- W4200596956 cites W1830084402 @default.
- W4200596956 cites W1854169465 @default.
- W4200596956 cites W1907219612 @default.
- W4200596956 cites W1949944365 @default.
- W4200596956 cites W1973861293 @default.
- W4200596956 cites W1975014115 @default.
- W4200596956 cites W1977767269 @default.
- W4200596956 cites W1978145149 @default.
- W4200596956 cites W1980129974 @default.
- W4200596956 cites W1980248069 @default.
- W4200596956 cites W1980972723 @default.
- W4200596956 cites W1987343071 @default.
- W4200596956 cites W1995398218 @default.
- W4200596956 cites W1997726430 @default.
- W4200596956 cites W1997742384 @default.
- W4200596956 cites W1998809668 @default.
- W4200596956 cites W1998989021 @default.
- W4200596956 cites W2002519246 @default.
- W4200596956 cites W2014205131 @default.
- W4200596956 cites W2014907650 @default.
- W4200596956 cites W2021932574 @default.
- W4200596956 cites W2026572571 @default.
- W4200596956 cites W2028868942 @default.
- W4200596956 cites W2030031808 @default.
- W4200596956 cites W2033374599 @default.
- W4200596956 cites W2037406895 @default.
- W4200596956 cites W2040280675 @default.
- W4200596956 cites W2040311013 @default.
- W4200596956 cites W2046997607 @default.
- W4200596956 cites W2058674469 @default.
- W4200596956 cites W2058815138 @default.
- W4200596956 cites W2061169432 @default.
- W4200596956 cites W2061800435 @default.
- W4200596956 cites W2062925683 @default.
- W4200596956 cites W2066113694 @default.
- W4200596956 cites W2066564488 @default.
- W4200596956 cites W2067870508 @default.
- W4200596956 cites W2067913177 @default.
- W4200596956 cites W2068153705 @default.
- W4200596956 cites W2076265695 @default.
- W4200596956 cites W2076353361 @default.
- W4200596956 cites W2089025864 @default.
- W4200596956 cites W2092536825 @default.
- W4200596956 cites W2100971797 @default.
- W4200596956 cites W2101626807 @default.
- W4200596956 cites W2101951807 @default.
- W4200596956 cites W2103272211 @default.
- W4200596956 cites W2103633745 @default.
- W4200596956 cites W2105466844 @default.
- W4200596956 cites W2114070455 @default.
- W4200596956 cites W2114499459 @default.
- W4200596956 cites W2115085987 @default.
- W4200596956 cites W2121114878 @default.
- W4200596956 cites W2127955519 @default.
- W4200596956 cites W2131911711 @default.
- W4200596956 cites W2132752670 @default.
- W4200596956 cites W2135778926 @default.
- W4200596956 cites W2144752708 @default.
- W4200596956 cites W2156584134 @default.
- W4200596956 cites W2164942645 @default.
- W4200596956 cites W2166364715 @default.
- W4200596956 cites W2174423712 @default.
- W4200596956 cites W2460928369 @default.
- W4200596956 cites W2473078753 @default.
- W4200596956 cites W2560435323 @default.
- W4200596956 cites W2574062068 @default.
- W4200596956 cites W2588514054 @default.
- W4200596956 cites W2760446596 @default.
- W4200596956 cites W2764126217 @default.
- W4200596956 cites W2769294499 @default.
- W4200596956 cites W2771729549 @default.
- W4200596956 cites W2783662278 @default.
- W4200596956 cites W2793467773 @default.
- W4200596956 cites W2802980066 @default.
- W4200596956 cites W2809999132 @default.
- W4200596956 cites W2883446651 @default.
- W4200596956 cites W2913202413 @default.
- W4200596956 cites W2914645254 @default.
- W4200596956 cites W2922251729 @default.
- W4200596956 cites W2945125308 @default.
- W4200596956 cites W2946660978 @default.
- W4200596956 cites W2964032077 @default.