Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200596979> ?p ?o ?g. }
Showing items 1 to 53 of
53
with 100 items per page.
- W4200596979 abstract "Purpose: We evaluated the level of sex hormones in female primary open angle glaucoma (POAG) patients to determine whether they are associated with the onset and/or progression of POAG. Methods: The cross-sectional study enrolled 63 women with POAG and 56 healthy women as normal control subjects. Furthermore, 57 women with POAG were included and followed-up for at least two years in the cohort study. All subjects were evaluated for serum concentration of sex hormones [prolactin (PRL), luteinizing hormone (LH), testosterone (TESTO), follicle-stimulating hormone (FSH), progesterone (PROG), and estrogen (E2)] and underwent visual field (VF) examination. In the cross-sectional study, Spearman analysis, linear regression analysis, and logistic regression analysis were performed to assess risk factors for POAG in females. In the cohort study, Cox regression analyses and Kaplan-Meier survival analysis were performed to identify factors associated with VF progression in women with POAG. Results: In the cross-sectional study, the level of E2 was significantly lower in the POAG group than in the normal group (P<0.05). Multiple logistic regression showed that the decreased level of E2 was a risk factor of POAG (OR=0.27, 95% CI=0.09 – 0.78, P<0.05), especially in premenopausal subjects. In the cohort study, there were 29 non-progression subjects and 28 progression subjects. Patients in the progression group had significantly lower levels of E2 than those in the no progression group (P<0.01). The decreased level of E2 at baseline was associated with POAG progression (HR=0.08, 95% CI=0.02 – 0.46, P<0.05), especially in premenopausal subjects. POAG patients with lower baseline E2 levels had significantly lower VF non-progression rates than patients with higher E2 levels (log-rank test P<0.001), especially premenopausal subjects (log-rank test P<0.05). Additionally, logistic regression analyses, Cox regression analyses, and Kaplan-Meier survival analysis showed that PROG, LH, FSH, and TESTO were risk factors of POAG and/or significantly associated with POAG progression. Conclusions: A decreased E2 level is a POAG risk factor and is associated with VF progression in women with POAG, especially in premenopausal subjects. Additionally, other sex hormones (PROG, LH, FSH, and TESTO) might also play a role in POAG pathogenesis." @default.
- W4200596979 created "2021-12-31" @default.
- W4200596979 date "2021-12-24" @default.
- W4200596979 modified "2023-09-24" @default.
- W4200596979 title "Image_1.TIFF" @default.
- W4200596979 doi "https://doi.org/10.3389/fnagi.2021.756186.s001" @default.
- W4200596979 hasPublicationYear "2021" @default.
- W4200596979 type Work @default.
- W4200596979 citedByCount "0" @default.
- W4200596979 crossrefType "component" @default.
- W4200596979 hasBestOaLocation W42005969791 @default.
- W4200596979 hasConcept C126322002 @default.
- W4200596979 hasConcept C142052008 @default.
- W4200596979 hasConcept C142724271 @default.
- W4200596979 hasConcept C151956035 @default.
- W4200596979 hasConcept C201903717 @default.
- W4200596979 hasConcept C2777164284 @default.
- W4200596979 hasConcept C2778575703 @default.
- W4200596979 hasConcept C2779064019 @default.
- W4200596979 hasConcept C29456083 @default.
- W4200596979 hasConcept C50440223 @default.
- W4200596979 hasConcept C71315377 @default.
- W4200596979 hasConcept C71924100 @default.
- W4200596979 hasConcept C72563966 @default.
- W4200596979 hasConceptScore W4200596979C126322002 @default.
- W4200596979 hasConceptScore W4200596979C142052008 @default.
- W4200596979 hasConceptScore W4200596979C142724271 @default.
- W4200596979 hasConceptScore W4200596979C151956035 @default.
- W4200596979 hasConceptScore W4200596979C201903717 @default.
- W4200596979 hasConceptScore W4200596979C2777164284 @default.
- W4200596979 hasConceptScore W4200596979C2778575703 @default.
- W4200596979 hasConceptScore W4200596979C2779064019 @default.
- W4200596979 hasConceptScore W4200596979C29456083 @default.
- W4200596979 hasConceptScore W4200596979C50440223 @default.
- W4200596979 hasConceptScore W4200596979C71315377 @default.
- W4200596979 hasConceptScore W4200596979C71924100 @default.
- W4200596979 hasConceptScore W4200596979C72563966 @default.
- W4200596979 hasLocation W42005969791 @default.
- W4200596979 hasOpenAccess W4200596979 @default.
- W4200596979 hasPrimaryLocation W42005969791 @default.
- W4200596979 hasRelatedWork W2226458 @default.
- W4200596979 hasRelatedWork W3187228845 @default.
- W4200596979 hasRelatedWork W3188605256 @default.
- W4200596979 hasRelatedWork W3188663839 @default.
- W4200596979 hasRelatedWork W3191231356 @default.
- W4200596979 hasRelatedWork W3192040958 @default.
- W4200596979 hasRelatedWork W4221017 @default.
- W4200596979 hasRelatedWork W4477477 @default.
- W4200596979 hasRelatedWork W5438179 @default.
- W4200596979 hasRelatedWork W5751625 @default.
- W4200596979 isParatext "false" @default.
- W4200596979 isRetracted "false" @default.
- W4200596979 workType "paratext" @default.