Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200599145> ?p ?o ?g. }
- W4200599145 endingPage "110352" @default.
- W4200599145 startingPage "110352" @default.
- W4200599145 abstract "Astrocyte activation is an important cause of neuropathic pain. Inhibiting the hyperactivation of astrocytes is beneficial to control over neuropathic pain. However, there is a lack of non-pharmaceutical ways to inhibit the hyperactivation of astrocytes. This study aimed at regulating the activity of glial cells via the architecture of 3D porous scaffolds. Herein, the 3D porous scaffolds with co-continuous and oriented pores were prepared via solid-phase stretching of co-continuous polymer blends followed by selective phase extraction. Compared to the isotropic scaffold, the proliferation of astrocytes slowed down on the oriented scaffolds. Meanwhile, the expression of growth factors and inflammatory factors secreted by astrocyte activation was inhibited by the oriented pores. It led to the suppression of the Wnt/β-catenin signaling pathway that is crucial to determine chronic neuropathic pain. Immunofluorescence staining displayed that the hyperactivation of astrocytes was inhibited, and the expression of kindlin-1, a key protein that activates astrocytes, was downregulated. The proposed strategy offers a probable physical means to relieve neuropathic pain." @default.
- W4200599145 created "2021-12-31" @default.
- W4200599145 creator A5009543264 @default.
- W4200599145 creator A5018878045 @default.
- W4200599145 creator A5023437328 @default.
- W4200599145 creator A5033372625 @default.
- W4200599145 creator A5035441361 @default.
- W4200599145 creator A5041160499 @default.
- W4200599145 creator A5041488867 @default.
- W4200599145 creator A5063059754 @default.
- W4200599145 creator A5064142978 @default.
- W4200599145 creator A5070986407 @default.
- W4200599145 creator A5090122963 @default.
- W4200599145 date "2021-12-01" @default.
- W4200599145 modified "2023-10-15" @default.
- W4200599145 title "Oriented Co-Continuous 3D Porous Scaffolds with Inhibited Activating Functionality: An Effective Strategy to Inhibit the Hyperactivation of Astrocytes" @default.
- W4200599145 cites W1972894972 @default.
- W4200599145 cites W2011281004 @default.
- W4200599145 cites W2016088070 @default.
- W4200599145 cites W2016474170 @default.
- W4200599145 cites W2028814484 @default.
- W4200599145 cites W2036908922 @default.
- W4200599145 cites W2040844744 @default.
- W4200599145 cites W2043946280 @default.
- W4200599145 cites W2058334887 @default.
- W4200599145 cites W2075992165 @default.
- W4200599145 cites W2087488678 @default.
- W4200599145 cites W2120102692 @default.
- W4200599145 cites W2127298360 @default.
- W4200599145 cites W2132359286 @default.
- W4200599145 cites W2135109455 @default.
- W4200599145 cites W2234168863 @default.
- W4200599145 cites W2326229548 @default.
- W4200599145 cites W2327536542 @default.
- W4200599145 cites W2341641698 @default.
- W4200599145 cites W2547814918 @default.
- W4200599145 cites W2553937521 @default.
- W4200599145 cites W2607560984 @default.
- W4200599145 cites W2611099748 @default.
- W4200599145 cites W2783592774 @default.
- W4200599145 cites W2789922692 @default.
- W4200599145 cites W2901960944 @default.
- W4200599145 cites W2902403596 @default.
- W4200599145 cites W2912187121 @default.
- W4200599145 cites W2943936118 @default.
- W4200599145 cites W2950601228 @default.
- W4200599145 cites W2961162867 @default.
- W4200599145 cites W2966811678 @default.
- W4200599145 cites W2974854894 @default.
- W4200599145 cites W2989783043 @default.
- W4200599145 cites W2990959386 @default.
- W4200599145 cites W2997320784 @default.
- W4200599145 cites W3003105913 @default.
- W4200599145 cites W3037544874 @default.
- W4200599145 cites W3037975981 @default.
- W4200599145 cites W3037994219 @default.
- W4200599145 cites W3038182041 @default.
- W4200599145 cites W3048502384 @default.
- W4200599145 cites W3093657652 @default.
- W4200599145 cites W3097700224 @default.
- W4200599145 cites W3120177040 @default.
- W4200599145 cites W3162221756 @default.
- W4200599145 doi "https://doi.org/10.1016/j.matdes.2021.110352" @default.
- W4200599145 hasPublicationYear "2021" @default.
- W4200599145 type Work @default.
- W4200599145 citedByCount "0" @default.
- W4200599145 crossrefType "journal-article" @default.
- W4200599145 hasAuthorship W4200599145A5009543264 @default.
- W4200599145 hasAuthorship W4200599145A5018878045 @default.
- W4200599145 hasAuthorship W4200599145A5023437328 @default.
- W4200599145 hasAuthorship W4200599145A5033372625 @default.
- W4200599145 hasAuthorship W4200599145A5035441361 @default.
- W4200599145 hasAuthorship W4200599145A5041160499 @default.
- W4200599145 hasAuthorship W4200599145A5041488867 @default.
- W4200599145 hasAuthorship W4200599145A5063059754 @default.
- W4200599145 hasAuthorship W4200599145A5064142978 @default.
- W4200599145 hasAuthorship W4200599145A5070986407 @default.
- W4200599145 hasAuthorship W4200599145A5090122963 @default.
- W4200599145 hasBestOaLocation W42005991451 @default.
- W4200599145 hasConcept C137620995 @default.
- W4200599145 hasConcept C169760540 @default.
- W4200599145 hasConcept C192562407 @default.
- W4200599145 hasConcept C2777107010 @default.
- W4200599145 hasConcept C2777542381 @default.
- W4200599145 hasConcept C2778366672 @default.
- W4200599145 hasConcept C529278444 @default.
- W4200599145 hasConcept C62478195 @default.
- W4200599145 hasConcept C71924100 @default.
- W4200599145 hasConcept C86803240 @default.
- W4200599145 hasConcept C95444343 @default.
- W4200599145 hasConcept C98274493 @default.
- W4200599145 hasConceptScore W4200599145C137620995 @default.
- W4200599145 hasConceptScore W4200599145C169760540 @default.
- W4200599145 hasConceptScore W4200599145C192562407 @default.
- W4200599145 hasConceptScore W4200599145C2777107010 @default.
- W4200599145 hasConceptScore W4200599145C2777542381 @default.
- W4200599145 hasConceptScore W4200599145C2778366672 @default.
- W4200599145 hasConceptScore W4200599145C529278444 @default.