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• W4200600361 abstract "Metabolic rewiring in tumor cells is a major hallmark of oncogenesis. Some of the oncometabolites drive suppressive and tolerogenic signals from the immune system, which becomes complicit to the advent and the survival of neoplasia. Tryptophan (TRP) catabolism through the kynurenine (KYN) pathway was reported to play immunosuppressive actions across many types of cancer. Extensive debate of whether the culprit of immunosuppression was the depletion of TRP or rather KYN accumulation in the tumor microenvironment has been ongoing for years. Results from clinical trials assessing the benefit of inhibiting key limiting enzymes of this pathway such as indoleamine 2,3-dioxygenase (IDO1) or tryptophan 2,3-dioxygenase (TDO2) failed to meet the expectations. Bearing in mind the complexity of the tumoral terrain and the existence of different cancers with IDO1/TDO2 expressing and non-expressing tumoral cells, here we present a comprehensive analysis of the TRP global metabolic hub and the driving potential of the process of oncogenesis with the main focus on liver cancers." @default.
• W4200600361 created "2021-12-31" @default.
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• W4200600361 creator A5081517670 @default.
• W4200600361 date "2021-12-09" @default.
• W4200600361 modified "2023-10-17" @default.
• W4200600361 title "Immuno-Metabolic Modulation of Liver Oncogenesis by the Tryptophan Metabolism" @default.
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• W4200600361 doi "https://doi.org/10.3390/cells10123469" @default.
• W4200600361 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34943977" @default.
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