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- W4200601439 abstract "Malaria elimination will be challenging in countries that currently continue to bear high malaria burden. Sex-ratio-distorting gene drives, such as driving-Y, could play a role in an integrated elimination strategy if they can effectively suppress vector populations. Using a spatially explicit, agent-based model of malaria transmission in eight provinces spanning the range of transmission intensities across the Democratic Republic of the Congo, we predict the impact and cost-effectiveness of integrating driving-Y gene drive mosquitoes in malaria elimination strategies that include existing interventions such as insecticide-treated nets and case management of symptomatic malaria. Gene drive mosquitoes could eliminate malaria and were the most cost-effective intervention overall if the drive component was highly effective with at least 95% X-shredder efficiency at relatively low fertility cost, and associated cost of deployment below 7.17 $int per person per year. Suppression gene drive could be a cost-effective supplemental intervention for malaria elimination, but tight constraints on drive effectiveness and cost ceilings may limit its feasibility." @default.
- W4200601439 created "2021-12-31" @default.
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- W4200601439 date "2022-01-01" @default.
- W4200601439 modified "2023-10-17" @default.
- W4200601439 title "Modeling impact and cost‐effectiveness of driving‐Y gene drives for malaria elimination in the Democratic Republic of the Congo" @default.
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- W4200601439 doi "https://doi.org/10.1111/eva.13331" @default.
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