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Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200601454> ?p ?o ?g. }

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• W4200601454 abstract "The recent emergence of COVID-19 variants has necessitated the development of new vaccines that stimulate the formation of high levels of neutralizing antibodies against S antigen variants. A new strategy involves the intradermal administration of heterologous vaccines composed of one or two doses of inactivated vaccine and a booster dose with the mutated S1 protein (K-S). Such vaccines improve the immune efficacy by increasing the neutralizing antibody titers and promoting specific T cell responses against five variants of the RBD protein. A viral challenge test with the B.1.617.2 (Delta) variant confirmed that both administration schedules (i.e. 1 + 1 and 2 + 1) ensured protection against this strain. These results suggest that the aforementioned strategy is effective for protecting against new variants and enhances the anamnestic immune response in the immunized population." @default.
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• W4200601454 date "2022-01-07" @default.
• W4200601454 modified "2023-10-18" @default.
• W4200601454 title "Preclinical immunological evaluation of an intradermal heterologous vaccine against SARS-CoV-2 variants" @default.
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• W4200601454 doi "https://doi.org/10.1080/22221751.2021.2021807" @default.
• W4200601454 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34931939" @default.
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