Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200609973> ?p ?o ?g. }
- W4200609973 endingPage "170717" @default.
- W4200609973 startingPage "170717" @default.
- W4200609973 abstract "ACE2 can regulate the development of intestinal inflammatory response, while the effect on LPS-induced inflammatory changes in porcine intestinal epithelial cells is still unclear. The present study investigated the role of ACE2 in inflammatory injury and the possible signaling pathways. The current results show that LPS cause inflammatory damage in IPEC-J2 cells and local RAS system was activated, with a significant correlation. ACE2 gene of IPEC-J2 cells are knocked down, and the inflammatory response are aggravated. ACE2 resist LPS-induced inflammation by degrading Ang II to produce Ang (1-7). The anti-inflammatory effect of ACE2 are mainly achieved by regulating the phosphorylation level of p65 in the NF-κB pathway and ERK1/2 in the MAPK pathway, reducing the expression and release of cellular inflammatory factors. These results reveal the biochemical mechanism of ACE2 against cellular inflammatory response and its potential application." @default.
- W4200609973 created "2021-12-31" @default.
- W4200609973 creator A5037947055 @default.
- W4200609973 creator A5041625094 @default.
- W4200609973 creator A5057562101 @default.
- W4200609973 creator A5073531557 @default.
- W4200609973 creator A5074461919 @default.
- W4200609973 date "2022-03-01" @default.
- W4200609973 modified "2023-10-18" @default.
- W4200609973 title "ACE2 suppresses the inflammatory response in LPS-induced porcine intestinal epithelial cells via regulating the NF-κB and MAPK pathways" @default.
- W4200609973 cites W1493793127 @default.
- W4200609973 cites W1523737655 @default.
- W4200609973 cites W1968279827 @default.
- W4200609973 cites W1976319679 @default.
- W4200609973 cites W1981298734 @default.
- W4200609973 cites W1986052203 @default.
- W4200609973 cites W1992557795 @default.
- W4200609973 cites W2004465286 @default.
- W4200609973 cites W2017614891 @default.
- W4200609973 cites W2050371471 @default.
- W4200609973 cites W2069690794 @default.
- W4200609973 cites W2087484128 @default.
- W4200609973 cites W2088422918 @default.
- W4200609973 cites W2106605319 @default.
- W4200609973 cites W2128921112 @default.
- W4200609973 cites W2149146712 @default.
- W4200609973 cites W2164359741 @default.
- W4200609973 cites W2295658637 @default.
- W4200609973 cites W2315222346 @default.
- W4200609973 cites W2342967881 @default.
- W4200609973 cites W2516565347 @default.
- W4200609973 cites W2770842062 @default.
- W4200609973 doi "https://doi.org/10.1016/j.peptides.2021.170717" @default.
- W4200609973 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34933009" @default.
- W4200609973 hasPublicationYear "2022" @default.
- W4200609973 type Work @default.
- W4200609973 citedByCount "6" @default.
- W4200609973 countsByYear W42006099732022 @default.
- W4200609973 countsByYear W42006099732023 @default.
- W4200609973 crossrefType "journal-article" @default.
- W4200609973 hasAuthorship W4200609973A5037947055 @default.
- W4200609973 hasAuthorship W4200609973A5041625094 @default.
- W4200609973 hasAuthorship W4200609973A5057562101 @default.
- W4200609973 hasAuthorship W4200609973A5073531557 @default.
- W4200609973 hasAuthorship W4200609973A5074461919 @default.
- W4200609973 hasConcept C104317684 @default.
- W4200609973 hasConcept C11960822 @default.
- W4200609973 hasConcept C123298856 @default.
- W4200609973 hasConcept C164027704 @default.
- W4200609973 hasConcept C185592680 @default.
- W4200609973 hasConcept C203014093 @default.
- W4200609973 hasConcept C2776914184 @default.
- W4200609973 hasConcept C2777730290 @default.
- W4200609973 hasConcept C2778754761 @default.
- W4200609973 hasConcept C3020196126 @default.
- W4200609973 hasConcept C502942594 @default.
- W4200609973 hasConcept C55493867 @default.
- W4200609973 hasConcept C57074206 @default.
- W4200609973 hasConcept C62478195 @default.
- W4200609973 hasConcept C86339819 @default.
- W4200609973 hasConcept C86803240 @default.
- W4200609973 hasConcept C95444343 @default.
- W4200609973 hasConceptScore W4200609973C104317684 @default.
- W4200609973 hasConceptScore W4200609973C11960822 @default.
- W4200609973 hasConceptScore W4200609973C123298856 @default.
- W4200609973 hasConceptScore W4200609973C164027704 @default.
- W4200609973 hasConceptScore W4200609973C185592680 @default.
- W4200609973 hasConceptScore W4200609973C203014093 @default.
- W4200609973 hasConceptScore W4200609973C2776914184 @default.
- W4200609973 hasConceptScore W4200609973C2777730290 @default.
- W4200609973 hasConceptScore W4200609973C2778754761 @default.
- W4200609973 hasConceptScore W4200609973C3020196126 @default.
- W4200609973 hasConceptScore W4200609973C502942594 @default.
- W4200609973 hasConceptScore W4200609973C55493867 @default.
- W4200609973 hasConceptScore W4200609973C57074206 @default.
- W4200609973 hasConceptScore W4200609973C62478195 @default.
- W4200609973 hasConceptScore W4200609973C86339819 @default.
- W4200609973 hasConceptScore W4200609973C86803240 @default.
- W4200609973 hasConceptScore W4200609973C95444343 @default.
- W4200609973 hasFunder F4320321001 @default.
- W4200609973 hasFunder F4320327518 @default.
- W4200609973 hasLocation W42006099731 @default.
- W4200609973 hasLocation W42006099732 @default.
- W4200609973 hasOpenAccess W4200609973 @default.
- W4200609973 hasPrimaryLocation W42006099731 @default.
- W4200609973 hasRelatedWork W1994284968 @default.
- W4200609973 hasRelatedWork W2088547254 @default.
- W4200609973 hasRelatedWork W2135919238 @default.
- W4200609973 hasRelatedWork W2411301702 @default.
- W4200609973 hasRelatedWork W2594878379 @default.
- W4200609973 hasRelatedWork W2787331413 @default.
- W4200609973 hasRelatedWork W2900935596 @default.
- W4200609973 hasRelatedWork W4200609973 @default.
- W4200609973 hasRelatedWork W4287621719 @default.
- W4200609973 hasRelatedWork W3083513165 @default.
- W4200609973 hasVolume "149" @default.
- W4200609973 isParatext "false" @default.
- W4200609973 isRetracted "false" @default.