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• W4200612021 abstract "Many factors must be considered and discussed with women when initiating a contraceptive method and the risk of venous thromboembolism (VTE) is one of them. In this review, we discuss the numerous strategies that have been implemented to reduce the thrombotic risk associated with combined oral contraceptives (COCs) from their arrival on the market until today. Evidences suggesting that COCs were associated with an increased risk of VTE appeared rapidly after their marketing. Identified as the main contributor of this risk, the dosage of the estrogen, i.e., ethinylestradiol (EE), was significantly reduced. New progestins were also synthetized (e.g., desogestrel or gestodene) but their weak androgenic activity did not permit to counterbalance the effect of EE as did the initial progestins such as levonorgestrel. Numerous studies assessed the impact of estroprogestative combinations on hemostasis and demonstrated that women under COC suffered from resistance towards activated protein C (APC). Subsequently, the European Medicines Agency updated its guidelines on clinical investigation of steroid contraceptives in which they recommended to assess this biological marker. In 2009, estradiol-containing COCs were marketed and the use of this natural form of estrogen was found to exert a weaker effect on the synthesis of hepatic proteins compared to EE. In this year 2021, a novel COC based on a native estrogen, i.e., estetrol, will be introduced on the market. Associated with drospirenone, this preparation demonstrated minor effects on coagulation proteins as compared with other drospirenone-containing COCs. At the present time, the standard of care when starting a contraception, consists of identifying the presence of hereditary thrombophilia solely on the basis of familial history of VTE. This strategy has however been reported as poorly predictive of hereditary thrombophilia. One rationale and affordable perspective which has already been considered in the past could be the implementation of a baseline screening of the prothrombotic state to provide health care professionals with objective data to support the prescription of the more appropriate contraceptive method. While this strategy was judged too expensive due to limited laboratory solutions, the endogenous thrombin potential-based APC resistance assay could now represent an interesting alternative." @default.
• W4200612021 created "2021-12-31" @default.
• W4200612021 creator A5009413902 @default.
• W4200612021 creator A5034895260 @default.
• W4200612021 creator A5035393567 @default.
• W4200612021 creator A5041424887 @default.
• W4200612021 creator A5078686392 @default.
• W4200612021 date "2021-12-09" @default.
• W4200612021 modified "2023-10-11" @default.
• W4200612021 title "Combined Oral Contraceptives and Venous Thromboembolism: Review and Perspective to Mitigate the Risk" @default.
• W4200612021 cites W1527990158 @default.
• W4200612021 cites W1562326026 @default.
• W4200612021 cites W1574745824 @default.
• W4200612021 cites W1575218991 @default.
• W4200612021 cites W1593764750 @default.
• W4200612021 cites W1722228117 @default.
• W4200612021 cites W1776852909 @default.
• W4200612021 cites W1784968408 @default.
• W4200612021 cites W1821983332 @default.
• W4200612021 cites W1935993340 @default.
• W4200612021 cites W194649371 @default.
• W4200612021 cites W1964279869 @default.
• W4200612021 cites W1965958910 @default.
• W4200612021 cites W1967108695 @default.
• W4200612021 cites W1971661444 @default.
• W4200612021 cites W1979306178 @default.
• W4200612021 cites W1985534394 @default.
• W4200612021 cites W1986625580 @default.
• W4200612021 cites W1988686137 @default.
• W4200612021 cites W1991391345 @default.
• W4200612021 cites W1995474189 @default.
• W4200612021 cites W2003982276 @default.
• W4200612021 cites W2004834643 @default.
• W4200612021 cites W2008539728 @default.
• W4200612021 cites W2008787839 @default.
• W4200612021 cites W2012139589 @default.
• W4200612021 cites W2014984303 @default.
• W4200612021 cites W2016235620 @default.
• W4200612021 cites W2021257902 @default.
• W4200612021 cites W2022857932 @default.
• W4200612021 cites W2024385537 @default.
• W4200612021 cites W2025078675 @default.
• W4200612021 cites W2025809926 @default.
• W4200612021 cites W2031517239 @default.
• W4200612021 cites W2031730012 @default.
• W4200612021 cites W2032238979 @default.
• W4200612021 cites W2036003181 @default.
• W4200612021 cites W2036117417 @default.
• W4200612021 cites W2037202881 @default.
• W4200612021 cites W2038520519 @default.
• W4200612021 cites W2042432382 @default.
• W4200612021 cites W2042860615 @default.
• W4200612021 cites W204526584 @default.
• W4200612021 cites W2046922887 @default.
• W4200612021 cites W2047235841 @default.
• W4200612021 cites W2050226103 @default.
• W4200612021 cites W2068178626 @default.
• W4200612021 cites W2068872138 @default.
• W4200612021 cites W2069343109 @default.
• W4200612021 cites W2070154645 @default.
• W4200612021 cites W2073070651 @default.
• W4200612021 cites W2073747638 @default.
• W4200612021 cites W2074032101 @default.
• W4200612021 cites W2081805706 @default.
• W4200612021 cites W2084532855 @default.
• W4200612021 cites W2087603337 @default.
• W4200612021 cites W2094220317 @default.
• W4200612021 cites W2100560126 @default.
• W4200612021 cites W2104231345 @default.
• W4200612021 cites W2105016255 @default.
• W4200612021 cites W2107726404 @default.
• W4200612021 cites W2109958433 @default.
• W4200612021 cites W2113184125 @default.
• W4200612021 cites W2115436778 @default.
• W4200612021 cites W2117066528 @default.
• W4200612021 cites W2125189710 @default.
• W4200612021 cites W2131435871 @default.
• W4200612021 cites W2133101757 @default.
• W4200612021 cites W2134873494 @default.
• W4200612021 cites W2141046130 @default.
• W4200612021 cites W2141317767 @default.
• W4200612021 cites W2141469801 @default.
• W4200612021 cites W2144509180 @default.
• W4200612021 cites W2145193603 @default.
• W4200612021 cites W2150882666 @default.
• W4200612021 cites W2153439743 @default.
• W4200612021 cites W2159972745 @default.
• W4200612021 cites W2162765338 @default.
• W4200612021 cites W2166312673 @default.
• W4200612021 cites W2167988325 @default.
• W4200612021 cites W2169015792 @default.
• W4200612021 cites W2172229479 @default.
• W4200612021 cites W2328547014 @default.
• W4200612021 cites W2336524823 @default.
• W4200612021 cites W2346324895 @default.
• W4200612021 cites W2346414905 @default.
• W4200612021 cites W2415726463 @default.
• W4200612021 cites W2463663663 @default.
• W4200612021 cites W2562653097 @default.
• W4200612021 cites W2618142594 @default.

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