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• W4200624596 abstract "Tumor contexture has emerged as a major prognostic determinant and tumor infiltrating CD8+ T cells have been associated with a better prognosis in several solid tumors, including early-stage colorectal cancer (CRC). However, the tumor immune infiltrate is highly heterogeneous and understanding how the interplay between different immune cell compartments impacts on the clinical outcome is still in its infancy. Here, we describe in a prospective cohort a novel CD8+ T effector memory population, which is characterized by high levels of Granzyme K (GZMKhigh CD8+ TEM) and is correlated with CD15high tumor infiltrating neutrophils. We provide both in vitro and in vivo evidence of the role of stromal cell-derived factor 1 (CXCL12/SDF-1) in driving functional changes on neutrophils at the tumor site, promoting their retention and increasing the crosstalk with CD8+ T cells. Mechanistically, as a consequence of the interaction with neutrophils, CD8+ T cells are skewed towards a CD8+ TEM phenotype and produce high levels of GZMK, which in turn decreases E-cadherin pathway. The correlations of GZMKhigh CD8+ TEM and neutrophils with both tumor progression in mice and early relapse in CRC patients demonstrate the role of GZMKhigh CD8+ TEM in promoting malignancy. Indeed, a gene signature defining GZMKhigh CD8+ TEM was associated with worse prognosis on a larger independent cohort of CRC patients and a similar analysis was extended to lung cancer (TCGA). Overall, our results highlight the emergence of GZMKhigh CD8+ TEM in early-stage CRC tumors as a hallmark driven by the interaction with neutrophils, which could implement current patient stratification and be targeted by novel therapeutics." @default.
• W4200624596 created "2021-12-31" @default.
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• W4200624596 date "2021-12-15" @default.
• W4200624596 modified "2023-09-27" @default.
• W4200624596 title "GZMKhigh CD8+ T effector memory cells are associated with CD15high neutrophil abundance in early-stage colorectal tumors and predict poor clinical outcome." @default.
• W4200624596 cites W1107917109 @default.
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• W4200624596 cites W1577972394 @default.
• W4200624596 cites W1631320694 @default.
• W4200624596 cites W1859257957 @default.
• W4200624596 cites W1965188145 @default.
• W4200624596 cites W1971364446 @default.
• W4200624596 cites W1974328925 @default.
• W4200624596 cites W1979790110 @default.
• W4200624596 cites W1980474981 @default.
• W4200624596 cites W1980693461 @default.
• W4200624596 cites W1987473368 @default.
• W4200624596 cites W1989111278 @default.
• W4200624596 cites W1995275059 @default.
• W4200624596 cites W1996118868 @default.
• W4200624596 cites W1999159926 @default.
• W4200624596 cites W2002157461 @default.
• W4200624596 cites W2009801524 @default.
• W4200624596 cites W2011143480 @default.
• W4200624596 cites W2026882289 @default.
• W4200624596 cites W2027344845 @default.
• W4200624596 cites W2028433016 @default.
• W4200624596 cites W2029684134 @default.
• W4200624596 cites W2042010971 @default.
• W4200624596 cites W2044502434 @default.
• W4200624596 cites W2050261429 @default.
• W4200624596 cites W2050604953 @default.
• W4200624596 cites W2067931754 @default.
• W4200624596 cites W2073932189 @default.
• W4200624596 cites W2086049503 @default.
• W4200624596 cites W2090312211 @default.
• W4200624596 cites W2090360086 @default.
• W4200624596 cites W2093381200 @default.
• W4200624596 cites W2099369787 @default.
• W4200624596 cites W2103576689 @default.
• W4200624596 cites W2115848444 @default.
• W4200624596 cites W2116407404 @default.
• W4200624596 cites W2128506942 @default.
• W4200624596 cites W2130989367 @default.
• W4200624596 cites W2134448305 @default.
• W4200624596 cites W2138694950 @default.
• W4200624596 cites W2149441684 @default.
• W4200624596 cites W2151862596 @default.
• W4200624596 cites W2152514732 @default.
• W4200624596 cites W2152961129 @default.
• W4200624596 cites W2157824068 @default.
• W4200624596 cites W2158485828 @default.
• W4200624596 cites W2158591788 @default.
• W4200624596 cites W2158957141 @default.
• W4200624596 cites W2161074777 @default.
• W4200624596 cites W2162154526 @default.
• W4200624596 cites W2165848159 @default.
• W4200624596 cites W2167279371 @default.
• W4200624596 cites W2169776780 @default.
• W4200624596 cites W2297284707 @default.
• W4200624596 cites W2341604280 @default.
• W4200624596 cites W2411767313 @default.
• W4200624596 cites W2474950788 @default.
• W4200624596 cites W2570947205 @default.
• W4200624596 cites W2579462828 @default.
• W4200624596 cites W2611596972 @default.
• W4200624596 cites W2619298951 @default.
• W4200624596 cites W2763257724 @default.
• W4200624596 cites W2771342962 @default.
• W4200624596 cites W2775714903 @default.
• W4200624596 cites W2787698240 @default.
• W4200624596 cites W2801309958 @default.
• W4200624596 cites W2802967146 @default.
• W4200624596 cites W2804073610 @default.
• W4200624596 cites W2808837841 @default.
• W4200624596 cites W2849303123 @default.
• W4200624596 cites W2889984138 @default.

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