Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200625302> ?p ?o ?g. }
- W4200625302 abstract "The heterogeneity of mesenchymal stem cells (MSCs) is poorly understood, thus limiting clinical application and basic research reproducibility. Advanced single-cell RNA sequencing (scRNA-seq) is a robust tool used to analyse for dissecting cellular heterogeneity. However, the comprehensive single-cell atlas for human MSCs has not been achieved.This study used massive parallel multiplexing scRNA-seq to construct an atlas of > 130 000 single-MSC transcriptomes across multiple tissues and donors to assess their heterogeneity. The most widely clinically utilised tissue resources for MSCs were collected, including normal bone marrow (n = 3), adipose (n = 3), umbilical cord (n = 2), and dermis (n = 3).Seven tissue-specific and five conserved MSC subpopulations with distinct gene-expression signatures were identified from multiple tissue origins based on the high-quality data, which has not been achieved previously. This study showed that extracellular matrix (ECM) highly contributes to MSC heterogeneity. Notably, tissue-specific MSC subpopulations were substantially heterogeneous on ECM-associated immune regulation, antigen processing/presentation, and senescence, thus promoting inter-donor and intra-tissue heterogeneity. The variable dynamics of ECM-associated genes had discrete trajectory patterns across multiple tissues. Additionally, the conserved and tissue-specific transcriptomic-regulons and protein-protein interactions were identified, potentially representing common or tissue-specific MSC functional roles. Furthermore, the umbilical-cord-specific subpopulation possessed advantages in immunosuppressive properties.In summary, this work provides timely and great insights into MSC heterogeneity at multiple levels. This MSC atlas taxonomy also provides a comprehensive understanding of cellular heterogeneity, thus revealing the potential improvements in MSC-based therapeutic efficacy." @default.
- W4200625302 created "2021-12-31" @default.
- W4200625302 creator A5011396539 @default.
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- W4200625302 creator A5086102846 @default.
- W4200625302 creator A5090898287 @default.
- W4200625302 date "2021-12-01" @default.
- W4200625302 modified "2023-10-16" @default.
- W4200625302 title "Single‐cell transcriptome atlas of human mesenchymal stem cells exploring cellular heterogeneity" @default.
- W4200625302 cites W103905185 @default.
- W4200625302 cites W109230952 @default.
- W4200625302 cites W1560839247 @default.
- W4200625302 cites W1583843783 @default.
- W4200625302 cites W1827463259 @default.
- W4200625302 cites W1858621903 @default.
- W4200625302 cites W1935205446 @default.
- W4200625302 cites W1977583598 @default.
- W4200625302 cites W1978468353 @default.
- W4200625302 cites W1982358713 @default.
- W4200625302 cites W1982721359 @default.
- W4200625302 cites W1988009411 @default.
- W4200625302 cites W1995547197 @default.
- W4200625302 cites W1997675408 @default.
- W4200625302 cites W1998728654 @default.
- W4200625302 cites W2006970842 @default.
- W4200625302 cites W2010548987 @default.
- W4200625302 cites W2014140341 @default.
- W4200625302 cites W2015475019 @default.
- W4200625302 cites W2019235245 @default.
- W4200625302 cites W2023738576 @default.
- W4200625302 cites W2025726874 @default.
- W4200625302 cites W2034605627 @default.
- W4200625302 cites W2050681882 @default.
- W4200625302 cites W2060678499 @default.
- W4200625302 cites W2064442490 @default.
- W4200625302 cites W2067764717 @default.
- W4200625302 cites W2074774606 @default.
- W4200625302 cites W2078719918 @default.
- W4200625302 cites W2084882319 @default.
- W4200625302 cites W2086280521 @default.
- W4200625302 cites W2087502781 @default.
- W4200625302 cites W2093836304 @default.
- W4200625302 cites W2100305481 @default.
- W4200625302 cites W2101143116 @default.
- W4200625302 cites W2102212449 @default.
- W4200625302 cites W2108881298 @default.
- W4200625302 cites W2115508261 @default.
- W4200625302 cites W2115852450 @default.
- W4200625302 cites W2131271579 @default.
- W4200625302 cites W2132478883 @default.
- W4200625302 cites W2138773756 @default.
- W4200625302 cites W2147005534 @default.
- W4200625302 cites W2147945242 @default.
- W4200625302 cites W2152877666 @default.
- W4200625302 cites W2153562609 @default.
- W4200625302 cites W2159675211 @default.
- W4200625302 cites W2161708262 @default.
- W4200625302 cites W2169456326 @default.
- W4200625302 cites W2190226813 @default.
- W4200625302 cites W2252399179 @default.
- W4200625302 cites W2302332254 @default.
- W4200625302 cites W2330927521 @default.
- W4200625302 cites W2339449699 @default.
- W4200625302 cites W2343956310 @default.
- W4200625302 cites W2475858879 @default.
- W4200625302 cites W2516428217 @default.
- W4200625302 cites W2533064745 @default.
- W4200625302 cites W2557833574 @default.
- W4200625302 cites W2558534012 @default.
- W4200625302 cites W2565728749 @default.
- W4200625302 cites W2582033455 @default.
- W4200625302 cites W2597078192 @default.
- W4200625302 cites W2625191040 @default.
- W4200625302 cites W2737662761 @default.
- W4200625302 cites W2765141896 @default.
- W4200625302 cites W2766437506 @default.
- W4200625302 cites W2773508782 @default.
- W4200625302 cites W2782454362 @default.
- W4200625302 cites W2783211174 @default.
- W4200625302 cites W2784395700 @default.
- W4200625302 cites W2785085486 @default.
- W4200625302 cites W2790210118 @default.
- W4200625302 cites W2792163037 @default.
- W4200625302 cites W2793690962 @default.
- W4200625302 cites W2793859699 @default.
- W4200625302 cites W2794410845 @default.
- W4200625302 cites W2794480084 @default.
- W4200625302 cites W2794521141 @default.
- W4200625302 cites W2794589539 @default.
- W4200625302 cites W2795867722 @default.
- W4200625302 cites W2797930701 @default.
- W4200625302 cites W2799523883 @default.
- W4200625302 cites W2800931995 @default.
- W4200625302 cites W2801149803 @default.