Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205092532> ?p ?o ?g. }
- W4205092532 abstract "Abstract Abnormal WNT signaling increases MYC expression in colon cancer cells in part via oncogenic super-enhancer-(OSE)-mediated gating of the active MYC to the nuclear pore in a poorly understood process. We show here that the principal tenet of the WNT-regulated MYC gating, facilitating nuclear export of the MYC mRNA, is regulated by a CTCF binding site (CTCFBS) within the OSE to confer growth advantage in HCT-116 cells. To achieve this, the CTCFBS directs the WNT-dependent trafficking of the OSE to the nuclear pore from intra-nucleoplasmic positions in a stepwise manner. Once the OSE reaches a peripheral position, which is triggered by a CTCFBS-mediated CCAT1 eRNA activation, its final stretch (≤0.7 μm) to the nuclear pore requires the recruitment of AHCTF1, a key nucleoporin, to the CTCFBS. Thus, a WNT/ß-catenin-AHCTF1-CTCF-eRNA circuit enables the OSE to promote pathological cell growth by coordinating the trafficking of the active MYC gene within the 3D nuclear architecture." @default.
- W4205092532 created "2022-01-26" @default.
- W4205092532 creator A5000268629 @default.
- W4205092532 creator A5006207510 @default.
- W4205092532 creator A5007918970 @default.
- W4205092532 creator A5014229545 @default.
- W4205092532 creator A5029141807 @default.
- W4205092532 creator A5033344049 @default.
- W4205092532 creator A5040848930 @default.
- W4205092532 creator A5042681178 @default.
- W4205092532 creator A5052202090 @default.
- W4205092532 creator A5058609302 @default.
- W4205092532 creator A5068155876 @default.
- W4205092532 creator A5072885078 @default.
- W4205092532 creator A5077612551 @default.
- W4205092532 creator A5089867341 @default.
- W4205092532 date "2022-01-11" @default.
- W4205092532 modified "2023-10-15" @default.
- W4205092532 title "Canonical WNT signaling-dependent gating of MYC requires a noncanonical CTCF function at a distal binding site" @default.
- W4205092532 cites W1904711187 @default.
- W4205092532 cites W1937904366 @default.
- W4205092532 cites W1964807436 @default.
- W4205092532 cites W1981437154 @default.
- W4205092532 cites W1984068087 @default.
- W4205092532 cites W1984189354 @default.
- W4205092532 cites W2004966039 @default.
- W4205092532 cites W2012935431 @default.
- W4205092532 cites W2014677321 @default.
- W4205092532 cites W2021341670 @default.
- W4205092532 cites W2044467718 @default.
- W4205092532 cites W2052766340 @default.
- W4205092532 cites W2053086049 @default.
- W4205092532 cites W2054746614 @default.
- W4205092532 cites W2057681391 @default.
- W4205092532 cites W2070380559 @default.
- W4205092532 cites W2078526277 @default.
- W4205092532 cites W2087413829 @default.
- W4205092532 cites W2090632681 @default.
- W4205092532 cites W2101129064 @default.
- W4205092532 cites W2102619694 @default.
- W4205092532 cites W2103441770 @default.
- W4205092532 cites W2110597220 @default.
- W4205092532 cites W2122029913 @default.
- W4205092532 cites W2124514674 @default.
- W4205092532 cites W2129785061 @default.
- W4205092532 cites W2131271579 @default.
- W4205092532 cites W2136932227 @default.
- W4205092532 cites W2138601221 @default.
- W4205092532 cites W2149994924 @default.
- W4205092532 cites W2168909179 @default.
- W4205092532 cites W2171808845 @default.
- W4205092532 cites W2547049198 @default.
- W4205092532 cites W2603330022 @default.
- W4205092532 cites W2761461280 @default.
- W4205092532 cites W2785060777 @default.
- W4205092532 cites W2796842840 @default.
- W4205092532 cites W2867868648 @default.
- W4205092532 cites W2889646832 @default.
- W4205092532 cites W2890876012 @default.
- W4205092532 cites W2921042206 @default.
- W4205092532 cites W2946235712 @default.
- W4205092532 cites W2964849163 @default.
- W4205092532 cites W2990225395 @default.
- W4205092532 cites W3006653136 @default.
- W4205092532 cites W3022604539 @default.
- W4205092532 cites W3049215545 @default.
- W4205092532 cites W3092440380 @default.
- W4205092532 doi "https://doi.org/10.1038/s41467-021-27868-3" @default.
- W4205092532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35017527" @default.
- W4205092532 hasPublicationYear "2022" @default.
- W4205092532 type Work @default.
- W4205092532 citedByCount "8" @default.
- W4205092532 countsByYear W42050925322022 @default.
- W4205092532 countsByYear W42050925322023 @default.
- W4205092532 crossrefType "journal-article" @default.
- W4205092532 hasAuthorship W4205092532A5000268629 @default.
- W4205092532 hasAuthorship W4205092532A5006207510 @default.
- W4205092532 hasAuthorship W4205092532A5007918970 @default.
- W4205092532 hasAuthorship W4205092532A5014229545 @default.
- W4205092532 hasAuthorship W4205092532A5029141807 @default.
- W4205092532 hasAuthorship W4205092532A5033344049 @default.
- W4205092532 hasAuthorship W4205092532A5040848930 @default.
- W4205092532 hasAuthorship W4205092532A5042681178 @default.
- W4205092532 hasAuthorship W4205092532A5052202090 @default.
- W4205092532 hasAuthorship W4205092532A5058609302 @default.
- W4205092532 hasAuthorship W4205092532A5068155876 @default.
- W4205092532 hasAuthorship W4205092532A5072885078 @default.
- W4205092532 hasAuthorship W4205092532A5077612551 @default.
- W4205092532 hasAuthorship W4205092532A5089867341 @default.
- W4205092532 hasBestOaLocation W42050925321 @default.
- W4205092532 hasConcept C104317684 @default.
- W4205092532 hasConcept C111936080 @default.
- W4205092532 hasConcept C12554922 @default.
- W4205092532 hasConcept C126725582 @default.
- W4205092532 hasConcept C137620995 @default.
- W4205092532 hasConcept C185592680 @default.
- W4205092532 hasConcept C190062978 @default.
- W4205092532 hasConcept C194544171 @default.
- W4205092532 hasConcept C2778760011 @default.
- W4205092532 hasConcept C2780114586 @default.