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- W4205121095 abstract "Abstract Objective Detecting peripheral nerve damage by electrophysiology examination accurately and sensitively is important for the follow-up evaluation of amyotrophic lateral sclerosis(ALS). In this study, we applied a new proximal E2 electrode in the ulnar motor nerve conduction study with E1 on abductor digiti minimi(ADM), and investigated its effect on the compound muscle action potential(CMAP) of the ulnar nerve. Methods We included 64 ALS patients and 64 age- and sex- matched controls. Patients characteristics were collected for phenotype, symptom duration and site of onset. The revised ALS Functional Rating Scale(ALSFRS-R) was evaluated at the time of administration to assess the severity of ALS. The ulnar nerve CMAP was recorded using an E1 electrode on the muscle belly and an E2 electrode on distal tendon(traditional montage, CMAP-dE2) and proximal tendon(new montage, CMAP-pE2) respectively. Results The waveform of CMAP-pE2 was steadier presenting a uniform unilobed pattern. In the controls, there were no significant differences between the amplitudes of CMAP-dE2 and CMAP-pE2( p =0.96). In ALS patients, the amplitude of CMAP-pE2 was significantly lower than that of CMAP-dE2( p <0.01), especially for patients with ADM spontaneous activity and muscular atrophy. Using the new method, the damaged axons were more likely to be stratified into more severe decreased levels. Furthermore, the decline of CMAP-pE2 was significantly correlated with ALSFRS-R( p <0.01). Conclusions The new electrode configuration in the ulnar nerve conduction test could reflect the degree of axonal injury much more sensitively after the presence of ulnar nerve degeneration and was more suitable for the evaluation of disease progression." @default.
- W4205121095 created "2022-01-25" @default.
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- W4205121095 date "2022-01-04" @default.
- W4205121095 modified "2023-09-29" @default.
- W4205121095 title "The Promising Application of a New Ulnar Nerve Compound Muscle Action Potential Measurement Montage in Amyotrophic Lateral Sclerosis" @default.
- W4205121095 doi "https://doi.org/10.21203/rs.3.rs-1185620/v1" @default.
- W4205121095 hasPublicationYear "2022" @default.
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