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- W4205124768 abstract "The major known genetic risk for Alzheimer's disease, apolipoprotein E-4, is associated with lowered cerebral glucose metabolism in brain regions showing Alzheimer's disease neuropathological damage. To determine metabolic decline patterns according to genetic risk, we investigated cerebral metabolic rates using positron emission tomography (PET) in middle-aged and older persons with normal memory performance. PET scans performed after two years showed the greatest magnitude (5%) and extent of metabolic decline in the inferior parietal and lateral temporal cortices in subjects at genetic risk for Alzheimer's disease. After correction for multiple comparisons, these metabolic changes remained significant for the apolipoprotein E-4 group where every subject had observable metabolic decline in these regions. These results indicate that combining cerebral rate and genetic risk measures provides a means for preclinical Alzheimer's disease detection that will assist in response monitoring during experimental treatments." @default.
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- W4205124768 date "2001-03-28" @default.
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- W4205124768 title "Influence of apoE Genotype and PET Brain Imaging on Preclinical Prediction of Alzheimer's Disease" @default.
- W4205124768 doi "https://doi.org/10.1002/0470846453.ch18" @default.
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