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• W4205125068 abstract "The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.1.7 lineage (labeled Alpha by WHO) rapidly emerged after its first identification in the United Kingdom in late 2020 (1). As of 1 June 2021, B.1.1.7 was verified in 160 countries and had become the dominant variant in several European countries, including Germany, and in North America (2–4). In November 2021, the global epidemiology of SARS-CoV-2 is characterized by a predominance of the B.1.617.2 lineage (labeled Delta), with the prevalence of other variants continuing to decline (B.1.1.7 prevalence is <0.1%) (5). B.1.1.7 is defined by a large number of mutations in the spike (S) gene and four in the nucleocapsid (N) gene (N protein substitutions D3L, R203K, G204R, and S235F) (6). Virus mutations have the potential to impact the accuracy of diagnostic tests. Most commercially available SARS-CoV-2 antigen-detecting rapid diagnostic tests (Ag-RDTs) target the viral N protein, encoded by the N gene (7). In an analytical evaluation by Public Health England, the B.1.1.7 variant did not affect the performance of six commercially available Ag-RDTs, all of which target the N protein, despite a limited number of amino acid changes from the original viral sequence in the target antigen (6, 8)." @default.
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• W4205125068 date "2022-02-23" @default.
• W4205125068 modified "2023-10-02" @default.
• W4205125068 title "SARS-CoV-2 Variant of Concern B.1.1.7: Diagnostic Sensitivity of Three Antigen-Detecting Rapid Tests" @default.
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• W4205125068 doi "https://doi.org/10.1128/spectrum.00763-21" @default.
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