Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205125680> ?p ?o ?g. }
- W4205125680 abstract "Alzheimer's disease (AD) is a devastating age-related neurodegenerative disorder with an alarming increasing prevalence. Except for the recently FDA-approved Aducanumab of which the therapeutic effect is not yet conclusively proven, only symptomatic medication that is effective for some AD patients is available. In order to be able to design more rational and effective treatments, our understanding of the mechanisms behind the pathogenesis and progression of AD urgently needs to be improved. Over the last years, it became increasingly clear that peripheral inflammation is one of the detrimental factors that can contribute to the disease. Here, we discuss the current understanding of how systemic and intestinal (referred to as the gut-brain axis) inflammatory processes may affect brain pathology, with a specific focus on AD. Moreover, we give a comprehensive overview of the different preclinical as well as clinical studies that link peripheral Inflammation to AD initiation and progression. Altogether, this review broadens our understanding of the mechanisms behind AD pathology and may help in the rational design of further research aiming to identify novel therapeutic targets." @default.
- W4205125680 created "2022-01-25" @default.
- W4205125680 creator A5014791123 @default.
- W4205125680 creator A5024543793 @default.
- W4205125680 creator A5043807997 @default.
- W4205125680 date "2022-01-06" @default.
- W4205125680 modified "2023-10-05" @default.
- W4205125680 title "The Impact of Systemic Inflammation on Alzheimer’s Disease Pathology" @default.
- W4205125680 cites W132781887 @default.
- W4205125680 cites W1498693902 @default.
- W4205125680 cites W1507824769 @default.
- W4205125680 cites W1508289240 @default.
- W4205125680 cites W1515023627 @default.
- W4205125680 cites W1551080689 @default.
- W4205125680 cites W1569243387 @default.
- W4205125680 cites W1582192688 @default.
- W4205125680 cites W1607135210 @default.
- W4205125680 cites W1614579334 @default.
- W4205125680 cites W1767010801 @default.
- W4205125680 cites W1805149125 @default.
- W4205125680 cites W1841850981 @default.
- W4205125680 cites W1858567345 @default.
- W4205125680 cites W1916976076 @default.
- W4205125680 cites W1940136220 @default.
- W4205125680 cites W1963812982 @default.
- W4205125680 cites W1967161323 @default.
- W4205125680 cites W1968155895 @default.
- W4205125680 cites W1972218887 @default.
- W4205125680 cites W1973258762 @default.
- W4205125680 cites W1976445933 @default.
- W4205125680 cites W1981161904 @default.
- W4205125680 cites W1981801578 @default.
- W4205125680 cites W1984472672 @default.
- W4205125680 cites W1985329135 @default.
- W4205125680 cites W1987319516 @default.
- W4205125680 cites W1988761237 @default.
- W4205125680 cites W1988940166 @default.
- W4205125680 cites W1989113247 @default.
- W4205125680 cites W1991282216 @default.
- W4205125680 cites W1991993391 @default.
- W4205125680 cites W1993305977 @default.
- W4205125680 cites W1993909442 @default.
- W4205125680 cites W1993976394 @default.
- W4205125680 cites W1996321482 @default.
- W4205125680 cites W1996468782 @default.
- W4205125680 cites W1997962428 @default.
- W4205125680 cites W1998088268 @default.
- W4205125680 cites W1998105826 @default.
- W4205125680 cites W1998843397 @default.
- W4205125680 cites W1998981667 @default.
- W4205125680 cites W2000934457 @default.
- W4205125680 cites W2005076304 @default.
- W4205125680 cites W2009962309 @default.
- W4205125680 cites W2011429982 @default.
- W4205125680 cites W2015239548 @default.
- W4205125680 cites W2016148530 @default.
- W4205125680 cites W2017260345 @default.
- W4205125680 cites W2018708829 @default.
- W4205125680 cites W2020129294 @default.
- W4205125680 cites W2022850494 @default.
- W4205125680 cites W2023136593 @default.
- W4205125680 cites W2027021810 @default.
- W4205125680 cites W2029910155 @default.
- W4205125680 cites W2030094270 @default.
- W4205125680 cites W2031096177 @default.
- W4205125680 cites W2032036886 @default.
- W4205125680 cites W2038214340 @default.
- W4205125680 cites W2039098916 @default.
- W4205125680 cites W2040472175 @default.
- W4205125680 cites W2041546150 @default.
- W4205125680 cites W2044488773 @default.
- W4205125680 cites W2044975042 @default.
- W4205125680 cites W2045717926 @default.
- W4205125680 cites W2048371740 @default.
- W4205125680 cites W2048400917 @default.
- W4205125680 cites W2056188402 @default.
- W4205125680 cites W2057688664 @default.
- W4205125680 cites W2058959434 @default.
- W4205125680 cites W2059341594 @default.
- W4205125680 cites W2059491535 @default.
- W4205125680 cites W2064874359 @default.
- W4205125680 cites W2068649643 @default.
- W4205125680 cites W2068711486 @default.
- W4205125680 cites W2078068647 @default.
- W4205125680 cites W2082429191 @default.
- W4205125680 cites W2082969663 @default.
- W4205125680 cites W2083320551 @default.
- W4205125680 cites W2085159547 @default.
- W4205125680 cites W2085558085 @default.
- W4205125680 cites W2086474013 @default.
- W4205125680 cites W2086550669 @default.
- W4205125680 cites W2087243986 @default.
- W4205125680 cites W2088177247 @default.
- W4205125680 cites W2088349113 @default.
- W4205125680 cites W2093984890 @default.
- W4205125680 cites W2094953029 @default.
- W4205125680 cites W2096230282 @default.
- W4205125680 cites W2096410114 @default.
- W4205125680 cites W2096447610 @default.
- W4205125680 cites W2096500024 @default.