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- W4205125832 abstract "Organotin(IV) chemistry is nowadays in a continuous expansion due to the biological and medicinal potential found for some of these species. Within this study, the cytotoxic activity of several organotin(IV) compounds was investigated on two lung cancer cell lines (H522 and SK-MES-1) and on a normal lung cell line in order to have an overview of the toxicity and the selectivity of these derivatives. Moreover, the synthetic protocols, as well as the structural particularities of the novel organotin(IV) species, are also discussed. Hydrolysis of [2-{(CH2O)2CR}C6H4]2SnPh2 [R = H (1), Me (2)] with p-toluenesulfonic acid as a proton source afford the expected derivatives [2-(O═CR)C6H4]2SnPh2 [R = H (3), Me (4)]. When hydrochloric acid is used in these reactions, a chlorine-phenyl exchange took place in addition to the removal of the acetal fragments and the following products [2-(O═CR)C6H4]2SnPhCl [R = H (5), Me (6)] were isolated. Treatment of 5 with 2 equiv of 3-aminomethylpyridine in neat affords the imino(aryl)tin compound 2-(3′-PyCH2N═CH)C6H4]2SnPhCl (7). The reaction between 6 and potassium nicotinate allows the isolation of the organotin(IV) carboxylate [2-{O═C (CH3)}C6H4]2SnPh[O(O)CC5H4N-3] (8). Compounds 1–8 were characterized by multinuclear NMR spectroscopy in solution, mass spectrometry, and IR spectroscopy, and their molecular structures were confirmed by X-ray diffraction analysis. Compounds 1–8 were investigated for their antitumoral effects on Homo sapiens lung cancer cell lines (H522 and SK-MES-1) and on a normal bronchial epithelial cell line, BEAS-2B." @default.
- W4205125832 created "2022-01-26" @default.
- W4205125832 creator A5011775839 @default.
- W4205125832 creator A5020632057 @default.
- W4205125832 creator A5025159378 @default.
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- W4205125832 creator A5050838428 @default.
- W4205125832 creator A5051340308 @default.
- W4205125832 creator A5054954421 @default.
- W4205125832 creator A5056828347 @default.
- W4205125832 creator A5071498996 @default.
- W4205125832 creator A5090941723 @default.
- W4205125832 date "2022-01-03" @default.
- W4205125832 modified "2023-10-16" @default.
- W4205125832 title "<i>C</i> , <i>O</i> ‐Chelated organotin(IV) derivatives as potential anticancer agents: Synthesis, characterization, and cytotoxic activity" @default.
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- W4205125832 doi "https://doi.org/10.1002/aoc.6540" @default.