FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205125967> ?p ?o ?g. }

• W4205125967 endingPage "419" @default.
• W4205125967 startingPage "397" @default.
• W4205125967 abstract "Anhedonia, characterized by a lack of motivation, interest, or ability to experience pleasure, is a prominent symptom of depression and other psychiatric disorders and has been associated with poor response to standard therapies. One pathophysiologic pathway receiving increased attention for its potential role in anhedonia is inflammation and its effects on the brain. Exogenous administration of inflammatory stimuli to humans and laboratory animals has reliably been found to affect neurotransmitters and neurocircuits involved in reward processing, including the ventral striatum and ventromedial prefrontal cortex, in association with reduced motivation. Moreover, a rich literature including meta-analyses describes increased inflammation in a significant proportion of patients with depression and other psychiatric illnesses involving anhedonia, as evident by elevated inflammatory cytokines, acute phase proteins, chemokines, and adhesion molecules in both the periphery and central nervous system. This endogenous inflammation may arise from numerous sources including stress, obesity or metabolic dysfunction, genetics, and lifestyle factors, many of which are also risk factors for psychiatric illness. Consistent with laboratory studies involving exogenous administration of peripheral inflammatory stimuli, neuroimaging studies have further confirmed that increased endogenous inflammation in depression is associated with decreased activation of and reduced functional connectivity within reward circuits involving ventral striatum and ventromedial prefrontal cortex in association with anhedonia. Here, we review recent evidence of relationships between inflammation and anhedonia, while highlighting translational and mechanistic work describing the impact of inflammation on synthesis, release, and reuptake of neurotransmitters like dopamine and glutamate that affects circuits to drive motivational deficits. We will then present insight into novel pharmacological strategies that target either inflammation or its downstream effects on the brain and behavior. The meaningful translation of these concepts through appropriately designed trials targeting therapies for psychiatric patients with high inflammation and transdiagnostic symptoms of anhedonia is also discussed." @default.
• W4205125967 created "2022-01-25" @default.
• W4205125967 creator A5006125403 @default.
• W4205125967 creator A5082654985 @default.
• W4205125967 creator A5085103683 @default.
• W4205125967 date "2022-01-01" @default.
• W4205125967 modified "2023-10-06" @default.
• W4205125967 title "Inflammation as a Pathophysiologic Pathway to Anhedonia: Mechanisms and Therapeutic Implications" @default.
• W4205125967 cites W10954641 @default.
• W4205125967 cites W1626924345 @default.
• W4205125967 cites W1881742737 @default.
• W4205125967 cites W1950113474 @default.
• W4205125967 cites W1964744961 @default.
• W4205125967 cites W1969065116 @default.
• W4205125967 cites W1973172818 @default.
• W4205125967 cites W1975398216 @default.
• W4205125967 cites W1980305473 @default.
• W4205125967 cites W1981907384 @default.
• W4205125967 cites W1985438873 @default.
• W4205125967 cites W1985575431 @default.
• W4205125967 cites W1986187532 @default.
• W4205125967 cites W1987011950 @default.
• W4205125967 cites W1989199068 @default.
• W4205125967 cites W1989502746 @default.
• W4205125967 cites W1990532967 @default.
• W4205125967 cites W2003337582 @default.
• W4205125967 cites W2003982930 @default.
• W4205125967 cites W2004243143 @default.
• W4205125967 cites W2004462939 @default.
• W4205125967 cites W2008557926 @default.
• W4205125967 cites W2008760801 @default.
• W4205125967 cites W2015135718 @default.
• W4205125967 cites W2021594711 @default.
• W4205125967 cites W2031215299 @default.
• W4205125967 cites W2034528843 @default.
• W4205125967 cites W2034630933 @default.
• W4205125967 cites W2046572145 @default.
• W4205125967 cites W2053020615 @default.
• W4205125967 cites W2058584826 @default.
• W4205125967 cites W2060312436 @default.
• W4205125967 cites W2060913403 @default.
• W4205125967 cites W2061787025 @default.
• W4205125967 cites W2065796254 @default.
• W4205125967 cites W2069604660 @default.
• W4205125967 cites W2072059001 @default.
• W4205125967 cites W2072184805 @default.
• W4205125967 cites W2072799517 @default.
• W4205125967 cites W2083168772 @default.
• W4205125967 cites W2091259554 @default.
• W4205125967 cites W2092080673 @default.
• W4205125967 cites W2093949724 @default.
• W4205125967 cites W2094404268 @default.
• W4205125967 cites W2095931805 @default.
• W4205125967 cites W2096987707 @default.
• W4205125967 cites W2103858315 @default.
• W4205125967 cites W2104995588 @default.
• W4205125967 cites W2114058973 @default.
• W4205125967 cites W2121304943 @default.
• W4205125967 cites W2131398580 @default.
• W4205125967 cites W2136272373 @default.
• W4205125967 cites W2136812855 @default.
• W4205125967 cites W2149863291 @default.
• W4205125967 cites W2151702367 @default.
• W4205125967 cites W2155634762 @default.
• W4205125967 cites W2157620344 @default.
• W4205125967 cites W2161161114 @default.
• W4205125967 cites W2163146990 @default.
• W4205125967 cites W2196461303 @default.
• W4205125967 cites W2196538331 @default.
• W4205125967 cites W2199553413 @default.
• W4205125967 cites W2210219816 @default.
• W4205125967 cites W2217483770 @default.
• W4205125967 cites W2235730659 @default.
• W4205125967 cites W2236748756 @default.
• W4205125967 cites W2284757052 @default.
• W4205125967 cites W2302151110 @default.
• W4205125967 cites W2399060753 @default.
• W4205125967 cites W2468925656 @default.
• W4205125967 cites W2474892006 @default.
• W4205125967 cites W2503600544 @default.
• W4205125967 cites W2504468643 @default.
• W4205125967 cites W2507921187 @default.
• W4205125967 cites W2512238452 @default.
• W4205125967 cites W2519381186 @default.
• W4205125967 cites W2525291061 @default.
• W4205125967 cites W2549772552 @default.
• W4205125967 cites W2558133050 @default.
• W4205125967 cites W2582188919 @default.
• W4205125967 cites W2600760992 @default.
• W4205125967 cites W2604875756 @default.
• W4205125967 cites W2751999549 @default.
• W4205125967 cites W2757826926 @default.
• W4205125967 cites W2765985736 @default.
• W4205125967 cites W2767440265 @default.
• W4205125967 cites W2779380468 @default.
• W4205125967 cites W2792340030 @default.
• W4205125967 cites W2800380700 @default.
• W4205125967 cites W2801141358 @default.

• next