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• W4205127747 endingPage "106" @default.
• W4205127747 startingPage "87" @default.
• W4205127747 abstract "Preterm birth (PTB) is the leading cause of neonatal death. The essential strategy to prevent PTB is the accurate identification of threatened preterm labor (TPTL) women who will have PTB in a short time (< 7 days). Here, we aim to propose a clinical model to contribute to the effective prediction, precise prevention, and personalized medical treatment for PTB < 7 days in TPTL women through bioinformatics analysis and prospective cohort studies. In this study, the 1090 key genes involved in PTB < 7 days in the peripheral blood of TPTL women were ascertained using WGCNA. Based on this, the biological basis of immune-inflammatory activation (e.g., IFNγ and TNFα signaling) as well as immune cell disorders (e.g., monocytes and Th17 cells) in PTB < 7 days were revealed. Then, four core genes (JOSD1, IDNK, ZMYM3, and IL1B) that best represent their transcriptomic characteristics were screened by SVM and LASSO algorithm. Therefore, a prediction model with an AUC of 0.907 was constructed, which was validated in a larger population (AUC = 0.783). Moreover, the predictive value (AUC = 0.957) and clinical feasibility of this model were verified through the clinical prospective cohort we established. In conclusion, in the context of Predictive, Preventive, and Personalized Medicine (3PM), we have developed and validated a model to predict PTB < 7 days in TPTL women. This is promising to greatly improve the accuracy of clinical prediction, which would facilitate the personalized management of TPTL women to precisely prevent PTB < 7 days and improve maternal–fetal outcomes." @default.
• W4205127747 created "2022-01-26" @default.
• W4205127747 creator A5014289893 @default.
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• W4205127747 creator A5023055104 @default.
• W4205127747 creator A5045109662 @default.
• W4205127747 creator A5065771969 @default.
• W4205127747 creator A5070999619 @default.
• W4205127747 creator A5083159137 @default.
• W4205127747 creator A5086510648 @default.
• W4205127747 date "2022-01-18" @default.
• W4205127747 modified "2023-10-13" @default.
• W4205127747 title "Development and validation of a transcriptomic signature-based model as the predictive, preventive, and personalized medical strategy for preterm birth within 7 days in threatened preterm labor women" @default.
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