Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205145087> ?p ?o ?g. }
- W4205145087 endingPage "114122" @default.
- W4205145087 startingPage "114122" @default.
- W4205145087 abstract "The aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor, can regulate the immune balance of Th17/22 and Treg cells, which plays an important role in the development and maintenance of the skin barrier. We herein report the discovery of triazolopyridine derivatives as a new class of AhR agonists. Structure-activity relationship analyses led to the identification of the most active compound, 6-bromo-2-(4-bromophenyl)-[1,2,4]triazolo[1,5-a]pyridine (12a), with an EC50 (50% effective concentration) value of 0.03 nM. Compound 12a could induce rapid nuclear enrichment of AhR, trigger the transcription of downstream genes and promote skin barrier repair. Topical or oral administration of 12a could significantly alleviate imiquimod (IMQ)-induced psoriasis-like skin lesion. Considering the excellent in vivo anti-psoriasis activity as well as good pharmacokinetic properties, 12a could be a promising lead compound for drug discovery against psoriasis, and deserving further investigation." @default.
- W4205145087 created "2022-01-26" @default.
- W4205145087 creator A5000947783 @default.
- W4205145087 creator A5007992168 @default.
- W4205145087 creator A5051956004 @default.
- W4205145087 creator A5059894964 @default.
- W4205145087 creator A5060387564 @default.
- W4205145087 creator A5069425796 @default.
- W4205145087 date "2022-03-01" @default.
- W4205145087 modified "2023-10-02" @default.
- W4205145087 title "Identification of triazolopyridine derivatives as a new class of AhR agonists and evaluation of anti-psoriasis effect in a mouse model" @default.
- W4205145087 cites W1604295258 @default.
- W4205145087 cites W1905701786 @default.
- W4205145087 cites W1935479846 @default.
- W4205145087 cites W1971708477 @default.
- W4205145087 cites W1981177225 @default.
- W4205145087 cites W1987513348 @default.
- W4205145087 cites W1987784314 @default.
- W4205145087 cites W1993003564 @default.
- W4205145087 cites W2004522121 @default.
- W4205145087 cites W2006749681 @default.
- W4205145087 cites W2019103072 @default.
- W4205145087 cites W2040177546 @default.
- W4205145087 cites W2064230641 @default.
- W4205145087 cites W2067327580 @default.
- W4205145087 cites W2082331075 @default.
- W4205145087 cites W2084200591 @default.
- W4205145087 cites W2087589809 @default.
- W4205145087 cites W2103120331 @default.
- W4205145087 cites W2107312924 @default.
- W4205145087 cites W2112265988 @default.
- W4205145087 cites W2118380689 @default.
- W4205145087 cites W2125098787 @default.
- W4205145087 cites W2151197941 @default.
- W4205145087 cites W2160790213 @default.
- W4205145087 cites W2164880184 @default.
- W4205145087 cites W2196195787 @default.
- W4205145087 cites W2416624599 @default.
- W4205145087 cites W2476113381 @default.
- W4205145087 cites W2505069765 @default.
- W4205145087 cites W2510661649 @default.
- W4205145087 cites W2623658276 @default.
- W4205145087 cites W2768232933 @default.
- W4205145087 cites W2901813342 @default.
- W4205145087 cites W2924895007 @default.
- W4205145087 cites W2945623334 @default.
- W4205145087 cites W2981813829 @default.
- W4205145087 cites W3028355101 @default.
- W4205145087 cites W3131342971 @default.
- W4205145087 cites W4211077900 @default.
- W4205145087 cites W4246271143 @default.
- W4205145087 cites W4255940022 @default.
- W4205145087 doi "https://doi.org/10.1016/j.ejmech.2022.114122" @default.
- W4205145087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35123295" @default.
- W4205145087 hasPublicationYear "2022" @default.
- W4205145087 type Work @default.
- W4205145087 citedByCount "8" @default.
- W4205145087 countsByYear W42051450872022 @default.
- W4205145087 countsByYear W42051450872023 @default.
- W4205145087 crossrefType "journal-article" @default.
- W4205145087 hasAuthorship W4205145087A5000947783 @default.
- W4205145087 hasAuthorship W4205145087A5007992168 @default.
- W4205145087 hasAuthorship W4205145087A5051956004 @default.
- W4205145087 hasAuthorship W4205145087A5059894964 @default.
- W4205145087 hasAuthorship W4205145087A5060387564 @default.
- W4205145087 hasAuthorship W4205145087A5069425796 @default.
- W4205145087 hasConcept C104317684 @default.
- W4205145087 hasConcept C150903083 @default.
- W4205145087 hasConcept C185592680 @default.
- W4205145087 hasConcept C202751555 @default.
- W4205145087 hasConcept C203014093 @default.
- W4205145087 hasConcept C207001950 @default.
- W4205145087 hasConcept C2780035454 @default.
- W4205145087 hasConcept C2780564577 @default.
- W4205145087 hasConcept C33594762 @default.
- W4205145087 hasConcept C55493867 @default.
- W4205145087 hasConcept C71240020 @default.
- W4205145087 hasConcept C71924100 @default.
- W4205145087 hasConcept C86339819 @default.
- W4205145087 hasConcept C86803240 @default.
- W4205145087 hasConcept C8891405 @default.
- W4205145087 hasConcept C96529984 @default.
- W4205145087 hasConcept C98274493 @default.
- W4205145087 hasConceptScore W4205145087C104317684 @default.
- W4205145087 hasConceptScore W4205145087C150903083 @default.
- W4205145087 hasConceptScore W4205145087C185592680 @default.
- W4205145087 hasConceptScore W4205145087C202751555 @default.
- W4205145087 hasConceptScore W4205145087C203014093 @default.
- W4205145087 hasConceptScore W4205145087C207001950 @default.
- W4205145087 hasConceptScore W4205145087C2780035454 @default.
- W4205145087 hasConceptScore W4205145087C2780564577 @default.
- W4205145087 hasConceptScore W4205145087C33594762 @default.
- W4205145087 hasConceptScore W4205145087C55493867 @default.
- W4205145087 hasConceptScore W4205145087C71240020 @default.
- W4205145087 hasConceptScore W4205145087C71924100 @default.
- W4205145087 hasConceptScore W4205145087C86339819 @default.
- W4205145087 hasConceptScore W4205145087C86803240 @default.
- W4205145087 hasConceptScore W4205145087C8891405 @default.