Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205148977> ?p ?o ?g. }
- W4205148977 endingPage "209" @default.
- W4205148977 startingPage "209" @default.
- W4205148977 abstract "The dysregulation of gene expression is a critical event involved in all steps of tumorigenesis. Aberrant histone and non-histone acetylation modifications of gene expression due to the abnormal activation of histone deacetylases (HDAC) have been reported in hematologic and solid types of cancer. In this sense, the cancer-associated epigenetic alterations are promising targets for anticancer therapy and chemoprevention. HDAC inhibitors (HDACi) induce histone hyperacetylation within target proteins, altering cell cycle and proliferation, cell differentiation, and the regulation of cell death programs. Over the last three decades, an increasing number of synthetic and naturally derived compounds, such as dietary-derived products, have been demonstrated to act as HDACi and have provided biological and molecular insights with regard to the role of HDAC in cancer. The first part of this review is focused on the biological roles of the Zinc-dependent HDAC family in malignant diseases. Accordingly, the small-molecules and natural products such as HDACi are described in terms of cancer therapy and chemoprevention. Furthermore, structural considerations are included to improve the HDACi selectivity and combinatory potential with other specific targeting agents in bifunctional inhibitors and proteolysis targeting chimeras. Additionally, clinical trials that combine HDACi with current therapies are discussed, which may open new avenues in terms of the feasibility of HDACi's future clinical applications in precision cancer therapies." @default.
- W4205148977 created "2022-01-25" @default.
- W4205148977 creator A5016167522 @default.
- W4205148977 creator A5030700214 @default.
- W4205148977 creator A5049064278 @default.
- W4205148977 creator A5057385612 @default.
- W4205148977 creator A5066883045 @default.
- W4205148977 creator A5087886159 @default.
- W4205148977 date "2022-01-16" @default.
- W4205148977 modified "2023-10-13" @default.
- W4205148977 title "Targeting Histone Deacetylases: Opportunities for Cancer Treatment and Chemoprevention" @default.
- W4205148977 cites W1135478979 @default.
- W4205148977 cites W137915467 @default.
- W4205148977 cites W1563624749 @default.
- W4205148977 cites W1754523296 @default.
- W4205148977 cites W1814331574 @default.
- W4205148977 cites W18353697 @default.
- W4205148977 cites W1899314386 @default.
- W4205148977 cites W1949662878 @default.
- W4205148977 cites W1964951942 @default.
- W4205148977 cites W1967434207 @default.
- W4205148977 cites W1968076212 @default.
- W4205148977 cites W1970312374 @default.
- W4205148977 cites W1970990212 @default.
- W4205148977 cites W1971694393 @default.
- W4205148977 cites W1973010440 @default.
- W4205148977 cites W1974112332 @default.
- W4205148977 cites W1974451567 @default.
- W4205148977 cites W1974747095 @default.
- W4205148977 cites W1979362525 @default.
- W4205148977 cites W1980937575 @default.
- W4205148977 cites W1981569724 @default.
- W4205148977 cites W1982489603 @default.
- W4205148977 cites W1987220238 @default.
- W4205148977 cites W1987693456 @default.
- W4205148977 cites W1990953069 @default.
- W4205148977 cites W1993711510 @default.
- W4205148977 cites W1993943756 @default.
- W4205148977 cites W1994584016 @default.
- W4205148977 cites W1996103159 @default.
- W4205148977 cites W1998006710 @default.
- W4205148977 cites W1998928889 @default.
- W4205148977 cites W2002032142 @default.
- W4205148977 cites W2002265297 @default.
- W4205148977 cites W2005572311 @default.
- W4205148977 cites W2009954700 @default.
- W4205148977 cites W2010484468 @default.
- W4205148977 cites W2014887058 @default.
- W4205148977 cites W2015780246 @default.
- W4205148977 cites W2016040231 @default.
- W4205148977 cites W2020867376 @default.
- W4205148977 cites W2021379061 @default.
- W4205148977 cites W2021838661 @default.
- W4205148977 cites W2022051395 @default.
- W4205148977 cites W2028391746 @default.
- W4205148977 cites W2029658857 @default.
- W4205148977 cites W2029903254 @default.
- W4205148977 cites W2031050288 @default.
- W4205148977 cites W2033421610 @default.
- W4205148977 cites W2033582950 @default.
- W4205148977 cites W2035209422 @default.
- W4205148977 cites W2036411298 @default.
- W4205148977 cites W2036986058 @default.
- W4205148977 cites W2038050663 @default.
- W4205148977 cites W2038324148 @default.
- W4205148977 cites W2038458062 @default.
- W4205148977 cites W2040050212 @default.
- W4205148977 cites W2040257851 @default.
- W4205148977 cites W2041991583 @default.
- W4205148977 cites W2042889901 @default.
- W4205148977 cites W2043854938 @default.
- W4205148977 cites W2044570206 @default.
- W4205148977 cites W2045617306 @default.
- W4205148977 cites W2046467348 @default.
- W4205148977 cites W2047156022 @default.
- W4205148977 cites W2052887007 @default.
- W4205148977 cites W2054208176 @default.
- W4205148977 cites W2055021348 @default.
- W4205148977 cites W2057062872 @default.
- W4205148977 cites W2057529572 @default.
- W4205148977 cites W2057946453 @default.
- W4205148977 cites W2060300649 @default.
- W4205148977 cites W2063271327 @default.
- W4205148977 cites W2066748023 @default.
- W4205148977 cites W2067588084 @default.
- W4205148977 cites W2069595758 @default.
- W4205148977 cites W2070089404 @default.
- W4205148977 cites W2070785261 @default.
- W4205148977 cites W2071270678 @default.
- W4205148977 cites W2071513872 @default.
- W4205148977 cites W2073893367 @default.
- W4205148977 cites W2074006690 @default.
- W4205148977 cites W2081438162 @default.
- W4205148977 cites W2081675364 @default.
- W4205148977 cites W2082633436 @default.
- W4205148977 cites W2084326457 @default.
- W4205148977 cites W2084393474 @default.
- W4205148977 cites W2084868346 @default.