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- W4205153969 abstract "Abstract 3‐(piperydyl‐(N)‐methyl‐)indole and a number of derivatives with substituents in the piperidine‐nucleus, together with some related compounds, were synthesized as simplified analogues of the ergot alkaloïds. Some of them proved to be highly active on the rabbit uterus in situ (sensitized with estrone), the highest active 3‐(2′,6′‐dimethyl‐piperidyl‐(N)‐methyl)‐indole being half as effective as ergometrine. On the isolated uterus of the guinea pig in some cases the activity of the natural drug is surpassed. Structure/activity relationships are indicated, to be followed by a more extensive discussion after 3‐(piperidyl (2) methyl‐) indoles have been evaluated pharmacologically." @default.
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- W4205153969 date "1951-01-01" @default.
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- W4205153969 title "Synthetic oxytocics. I: 3‐(piperidyl‐(N)‐methyl‐)indoles and related compounds" @default.
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- W4205153969 doi "https://doi.org/10.1002/recl.19510701007" @default.
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