FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205156689> ?p ?o ?g. }

• W4205156689 abstract "Abstract Background Standard doses of second-generation H 1 -antihistamines (sgAHs) as first-line treatment are not always effective in treating chronic spontaneous urticaria (CSU), and hence an increase in the dose of sgAHs is recommended. However, literature evaluating the efଁcacy and safety of this treatment remains inconclusive, highlighting the need for a meta-analysis. The aim of this meta-analysis was to evaluate the efଁcacy and safety of high-dose sgAHs compared with standard-dose sgAHs in treating CSU. Methods A systematic literature search of double-blind, randomized controlled trials (RCT) utilizing multiple doses of sgAHs was performed by searching the electronic databases Medline, Embase, PsycINFO, Cochrane databases, and Web of Science. The response rate, the number of adverse events, somnolence, and withdrawal due to adverse events were extracted from each article. The data were combined and analyzed to quantify the safety and efficacy of the treatment. Results A total of 12 studies were identified, six of which met the eligibility criteria for the meta-analysis. Our pooled meta-analyses showed that high-dose sgAHs was associated with a significantly higher response rate than standard-dose (RR 1.12, 95% CI 1.01 to 1.24; P = 0.04). Conversely, high doses of sgAHs were associated with significantly higher somnolence rates than standard dose (RD 0.05, 95% CI 0.01 to 0.09; P = 0.02). There was no significant difference in adverse events or withdrawal due to adverse events between standard- and high-dose treatments. Conclusions Our analyses showed that a high dose of sgAHs (up to two times the standard dose) might be more effective than a standard dose in CSU treatment. High-dose and standard-dose sgAHs showed similar adverse events, except for somnolence, where incidence was found to be dose-dependent in some studies. However, given the limited number of studies, our meta-analysis results should be interpreted with caution." @default.
• W4205156689 created "2022-01-25" @default.
• W4205156689 creator A5003081598 @default.
• W4205156689 creator A5006911415 @default.
• W4205156689 creator A5008382979 @default.
• W4205156689 creator A5015964649 @default.
• W4205156689 creator A5034467280 @default.
• W4205156689 creator A5044475707 @default.
• W4205156689 creator A5046444648 @default.
• W4205156689 creator A5071768691 @default.
• W4205156689 creator A5081908047 @default.
• W4205156689 creator A5085765541 @default.
• W4205156689 creator A5086489565 @default.
• W4205156689 creator A5087031747 @default.
• W4205156689 date "2022-01-20" @default.
• W4205156689 modified "2023-09-24" @default.
• W4205156689 title "The Efficacy and Safety of High-Dose Nonsedating Antihistamines in Chronic Spontaneous Urticaria: A Systematic Review of Randomized Clinical Trials" @default.
• W4205156689 doi "https://doi.org/10.21203/rs.3.rs-1070216/v1" @default.
• W4205156689 hasPublicationYear "2022" @default.
• W4205156689 type Work @default.
• W4205156689 citedByCount "0" @default.
• W4205156689 crossrefType "posted-content" @default.
• W4205156689 hasAuthorship W4205156689A5003081598 @default.
• W4205156689 hasAuthorship W4205156689A5006911415 @default.
• W4205156689 hasAuthorship W4205156689A5008382979 @default.
• W4205156689 hasAuthorship W4205156689A5015964649 @default.
• W4205156689 hasAuthorship W4205156689A5034467280 @default.
• W4205156689 hasAuthorship W4205156689A5044475707 @default.
• W4205156689 hasAuthorship W4205156689A5046444648 @default.
• W4205156689 hasAuthorship W4205156689A5071768691 @default.
• W4205156689 hasAuthorship W4205156689A5081908047 @default.
• W4205156689 hasAuthorship W4205156689A5085765541 @default.
• W4205156689 hasAuthorship W4205156689A5086489565 @default.
• W4205156689 hasAuthorship W4205156689A5087031747 @default.
• W4205156689 hasConcept C126322002 @default.
• W4205156689 hasConcept C168563851 @default.
• W4205156689 hasConcept C17744445 @default.
• W4205156689 hasConcept C189708586 @default.
• W4205156689 hasConcept C197934379 @default.
• W4205156689 hasConcept C199539241 @default.
• W4205156689 hasConcept C2776478404 @default.
• W4205156689 hasConcept C2779034229 @default.
• W4205156689 hasConcept C2779473830 @default.
• W4205156689 hasConcept C71924100 @default.
• W4205156689 hasConcept C95190672 @default.
• W4205156689 hasConceptScore W4205156689C126322002 @default.
• W4205156689 hasConceptScore W4205156689C168563851 @default.
• W4205156689 hasConceptScore W4205156689C17744445 @default.
• W4205156689 hasConceptScore W4205156689C189708586 @default.
• W4205156689 hasConceptScore W4205156689C197934379 @default.
• W4205156689 hasConceptScore W4205156689C199539241 @default.
• W4205156689 hasConceptScore W4205156689C2776478404 @default.
• W4205156689 hasConceptScore W4205156689C2779034229 @default.
• W4205156689 hasConceptScore W4205156689C2779473830 @default.
• W4205156689 hasConceptScore W4205156689C71924100 @default.
• W4205156689 hasConceptScore W4205156689C95190672 @default.
• W4205156689 hasLocation W42051566891 @default.
• W4205156689 hasOpenAccess W4205156689 @default.
• W4205156689 hasPrimaryLocation W42051566891 @default.
• W4205156689 hasRelatedWork W1967911880 @default.
• W4205156689 hasRelatedWork W1996551696 @default.
• W4205156689 hasRelatedWork W2759947093 @default.
• W4205156689 hasRelatedWork W3027459656 @default.
• W4205156689 hasRelatedWork W3117110396 @default.
• W4205156689 hasRelatedWork W3134414398 @default.
• W4205156689 hasRelatedWork W3213074919 @default.
• W4205156689 hasRelatedWork W4226154391 @default.
• W4205156689 hasRelatedWork W4315488258 @default.
• W4205156689 hasRelatedWork W4360608871 @default.
• W4205156689 isParatext "false" @default.
• W4205156689 isRetracted "false" @default.
• W4205156689 workType "article" @default.