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- W4205157598 endingPage "187" @default.
- W4205157598 startingPage "187" @default.
- W4205157598 abstract "Sterilizing immunity after vaccination is desirable to prevent the spread of infection from vaccinees, which can be especially dangerous in hospital settings while managing frail patients. Sterilizing immunity requires neutralizing antibodies at the site of infection, which for respiratory viruses such as SARS-CoV-2 implies the occurrence of neutralizing IgA in mucosal secretions. Systemic vaccination by intramuscular delivery induces no or low-titer neutralizing IgA against vaccine antigens. Mucosal priming or boosting, is needed to provide sterilizing immunity. On the other side of the coin, sterilizing immunity, by zeroing interhuman transmission, could confine SARS-CoV-2 in animal reservoirs, preventing spontaneous attenuation of virulence in humans as presumably happened with the endemic coronaviruses. We review here the pros and cons of each vaccination strategy, the current mucosal SARS-CoV-2 vaccines under development, and their implications for public health." @default.
- W4205157598 created "2022-01-26" @default.
- W4205157598 creator A5042634861 @default.
- W4205157598 creator A5077902719 @default.
- W4205157598 creator A5089203948 @default.
- W4205157598 date "2022-01-19" @default.
- W4205157598 modified "2023-10-14" @default.
- W4205157598 title "Mucosal Vaccines, Sterilizing Immunity, and the Future of SARS-CoV-2 Virulence" @default.
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