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- W4205219209 startingPage "5" @default.
- W4205219209 abstract "This study was aimed at generating data for designing a potential method to prevent the rupture of the abdominal aortic aneurysm (AAA). We found that the mechanical strength and stiffness of blood vessel walls was enhanced by the crosslinking of adventitial collagen through a photochemical process promoted by ultraviolet-A (UV-A) radiation. The experiments were carried out on samples isolated from 25 normal porcine aortas. The adventitial layer was separated from the other layers and exposed to UV radiation of 365-nm wavelength, in the presence of a riboflavin compound as the photosensitizer. Mechanical testing of 30 specimens, prior to and after exposure, indicated an increase in both strength (ultimate stress) and stiffness (Young’s modulus) of the adventitial specimens following irradiation. The crosslinking process also led to an enhanced resistance to experimental collagenolysis, as determined on six specimens. At this phase of conceptual design, we suggest that by applying this method to an aneurysmal dilated wall region, the stabilization of tunica adventitia may delay or prevent the rupture of the aneurysm and, with further investigation and refinement, can become a therapeutic strategy for arresting the progression of AAA." @default.
- W4205219209 created "2022-01-26" @default.
- W4205219209 creator A5023155783 @default.
- W4205219209 creator A5031263732 @default.
- W4205219209 date "2022-01-12" @default.
- W4205219209 modified "2023-10-01" @default.
- W4205219209 title "Photocrosslinking of Adventitial Collagen in the Porcine Abdominal Aorta: A Preliminary Approach to a Strategy for Prevention of Aneurysmal Rupture" @default.
- W4205219209 cites W1513215086 @default.
- W4205219209 cites W1879222445 @default.
- W4205219209 cites W1915025757 @default.
- W4205219209 cites W192900258 @default.
- W4205219209 cites W1933544082 @default.
- W4205219209 cites W1964693177 @default.
- W4205219209 cites W1969749903 @default.
- W4205219209 cites W1975552178 @default.
- W4205219209 cites W1982903445 @default.
- W4205219209 cites W1990566772 @default.
- W4205219209 cites W1993258013 @default.
- W4205219209 cites W1996702326 @default.
- W4205219209 cites W2001465291 @default.
- W4205219209 cites W2002347326 @default.
- W4205219209 cites W2003765312 @default.
- W4205219209 cites W2005358475 @default.
- W4205219209 cites W2007644407 @default.
- W4205219209 cites W2018641849 @default.
- W4205219209 cites W2026547930 @default.
- W4205219209 cites W2033135205 @default.
- W4205219209 cites W2034415526 @default.
- W4205219209 cites W2035216444 @default.
- W4205219209 cites W2038813959 @default.
- W4205219209 cites W2039208650 @default.
- W4205219209 cites W2039283899 @default.
- W4205219209 cites W2043443402 @default.
- W4205219209 cites W2046231866 @default.
- W4205219209 cites W2049746776 @default.
- W4205219209 cites W2050380787 @default.
- W4205219209 cites W2053832395 @default.
- W4205219209 cites W2055772387 @default.
- W4205219209 cites W2063165518 @default.
- W4205219209 cites W2063302573 @default.
- W4205219209 cites W2065530999 @default.
- W4205219209 cites W2065593981 @default.
- W4205219209 cites W2067321859 @default.
- W4205219209 cites W2068706538 @default.
- W4205219209 cites W2071237192 @default.
- W4205219209 cites W2073677041 @default.
- W4205219209 cites W2078354113 @default.
- W4205219209 cites W2079995225 @default.
- W4205219209 cites W2080575943 @default.
- W4205219209 cites W2080918255 @default.
- W4205219209 cites W2087221410 @default.
- W4205219209 cites W2092641691 @default.
- W4205219209 cites W2094876228 @default.
- W4205219209 cites W2103109755 @default.
- W4205219209 cites W2103791313 @default.
- W4205219209 cites W2107582844 @default.
- W4205219209 cites W2112045938 @default.
- W4205219209 cites W2112123157 @default.
- W4205219209 cites W2138408681 @default.
- W4205219209 cites W2143334710 @default.
- W4205219209 cites W2143381614 @default.
- W4205219209 cites W2146410624 @default.
- W4205219209 cites W2146494060 @default.
- W4205219209 cites W2146751527 @default.
- W4205219209 cites W2152484902 @default.
- W4205219209 cites W2153532131 @default.
- W4205219209 cites W2156559614 @default.
- W4205219209 cites W2156914728 @default.
- W4205219209 cites W2171696642 @default.
- W4205219209 cites W2323285201 @default.
- W4205219209 cites W2394498607 @default.
- W4205219209 cites W2406549739 @default.
- W4205219209 cites W2510012344 @default.
- W4205219209 cites W2519342050 @default.
- W4205219209 cites W2530201739 @default.
- W4205219209 cites W2589082900 @default.
- W4205219209 cites W2604296804 @default.
- W4205219209 cites W2751436442 @default.
- W4205219209 cites W2789684089 @default.
- W4205219209 cites W2803299409 @default.
- W4205219209 cites W2808023004 @default.
- W4205219209 cites W2897966320 @default.
- W4205219209 cites W2901378137 @default.
- W4205219209 cites W2916049798 @default.
- W4205219209 cites W2945686673 @default.
- W4205219209 cites W2956069648 @default.
- W4205219209 cites W2993162398 @default.
- W4205219209 cites W2995342757 @default.
- W4205219209 cites W3013740975 @default.
- W4205219209 cites W3013982099 @default.
- W4205219209 cites W3019096900 @default.
- W4205219209 cites W3034561191 @default.
- W4205219209 cites W3081969151 @default.
- W4205219209 cites W3083088158 @default.
- W4205219209 cites W3112524032 @default.
- W4205219209 cites W3118580890 @default.
- W4205219209 cites W3136610806 @default.
- W4205219209 cites W3158183769 @default.