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- W4205219984 abstract "Trauma is a leading cause of death and morbidity worldwide. Here, we present the analysis of a longitudinal multi-omic dataset comprising clinical, cytokine, endotheliopathy biomarker, lipidome, metabolome, and proteome data from severely injured humans. A systemic storm pattern with release of 1,061 markers, together with a pattern suggestive of the massive consumption of 892 constitutive circulating markers, is identified in the acute phase post-trauma. Data integration reveals two human injury response endotypes, which align with clinical trajectory. Prehospital thawed plasma rescues only endotype 2 patients with traumatic brain injury (30-day mortality: 30.3 versus 75.0%; p = 0.0015). Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) was identified as the most predictive circulating biomarker to identify endotype 2-traumatic brain injury (TBI) patients. These response patterns refine the paradigm for human injury, while the datasets provide a resource for the study of critical illness, trauma, and human stress responses." @default.
- W4205219984 created "2022-01-25" @default.
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- W4205219984 date "2021-12-01" @default.
- W4205219984 modified "2023-10-17" @default.
- W4205219984 title "Multi-omic analysis in injured humans: Patterns align with outcomes and treatment responses" @default.
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- W4205219984 doi "https://doi.org/10.1016/j.xcrm.2021.100478" @default.
- W4205219984 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35028617" @default.
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