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• W4205224517 abstract "Significance The RAS–ERK pathway is critical for metazoan development. In development, ERK activity is regulated by a balance of phosphorylation of ERK by MEK (MAPK kinase) and dephosphorylation by DUSPs (dual specificity phosphatases). LIP-1, a DUSP6/7 family member, was previously suggested to regulate MPK-1/ERK activity by dephosphorylating MPK-1 in the Caenorhabditis elegans germline, based on LIP-1's mutant phenotype in the germline and its DUSP role in vulval development. However, our investigations demonstrate that LIP-1 does not function as an MPK-1 DUSP in the germline and likely regulates germline functions through distinct targets. Our results present a cautionary note about misinterpreting similar mutant phenotypes caused by mutations in different genes and assuming that genes function similarly in different tissues." @default.
• W4205224517 created "2022-01-26" @default.
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• W4205224517 date "2022-01-12" @default.
• W4205224517 modified "2023-10-14" @default.
• W4205224517 title "Reevaluation of the role of LIP-1 as an ERK/MPK-1 dual specificity phosphatase in the <i>C. elegans</i> germline" @default.
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• W4205224517 doi "https://doi.org/10.1073/pnas.2113649119" @default.
• W4205224517 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35022236" @default.
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