FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205231576> ?p ?o ?g. }

• W4205231576 endingPage "106080" @default.
• W4205231576 startingPage "106080" @default.
• W4205231576 abstract "Combination therapy system has become a promising strategy for achieving favorable antitumor efficacy. Herein, a novel oral drug delivery system with colon localization and tumor targeting functions was designed for orthotopic colon cancer chemotherapy and photothermal combinational therapy. The polydopamine coated nanodiamond (PND) was used as the photothermal carrier, through the coupling of sulfhydryl-polyethylene glycol-folate (SH-PEG-FA) on the surface of PND to achieve systematic colon tumor targeting, curcumin (CUR) was loaded as the model drug, and then coated with chitosan (CS) to achieve the long gastrointestinal tract retention and colon localization functions to obtain PND-PEG-FA/CUR@CS nanoparticles. It has high photothermal conversion efficiency and good photothermal stability and exhibited near-infrared (NIR) laser-responsive drug release behavior. Folate (FA) modification effectively promotes the intracellular uptake of nanoparticles by CT26 cells, and the combination of chemotherapy and photothermal therapy (CT/PTT) can enhance cytotoxicity. Compared with free CUR group, nanoparticles prolonged the gastrointestinal tract retention time, accumulated more in colon tumor tissues, and exhibited good photothermal effect in vivo. More importantly, the CT/PTT group exhibited satisfactory tumor growth inhibition effects with good biocompatibility in vivo. In summary, this oral drug delivery system is an efficient platform for chemotherapy and photothermal combinational therapy of orthotopic colon cancer." @default.
• W4205231576 created "2022-01-26" @default.
• W4205231576 creator A5006349365 @default.
• W4205231576 creator A5021485446 @default.
• W4205231576 creator A5025149008 @default.
• W4205231576 creator A5027640497 @default.
• W4205231576 creator A5033781225 @default.
• W4205231576 creator A5042074610 @default.
• W4205231576 creator A5080513377 @default.
• W4205231576 date "2022-02-01" @default.
• W4205231576 modified "2023-10-01" @default.
• W4205231576 title "Nanodiamond-based multifunctional platform for oral chemo-photothermal combinational therapy of orthotopic colon cancer" @default.
• W4205231576 cites W1480621313 @default.
• W4205231576 cites W1964836370 @default.
• W4205231576 cites W1994023367 @default.
• W4205231576 cites W2069043245 @default.
• W4205231576 cites W2146135493 @default.
• W4205231576 cites W2193581618 @default.
• W4205231576 cites W2224693399 @default.
• W4205231576 cites W2262355656 @default.
• W4205231576 cites W2306682522 @default.
• W4205231576 cites W2547438882 @default.
• W4205231576 cites W2555167393 @default.
• W4205231576 cites W2561349920 @default.
• W4205231576 cites W2579652888 @default.
• W4205231576 cites W2613630131 @default.
• W4205231576 cites W2744173175 @default.
• W4205231576 cites W2774246729 @default.
• W4205231576 cites W2790101095 @default.
• W4205231576 cites W2792856623 @default.
• W4205231576 cites W2805345717 @default.
• W4205231576 cites W2813804716 @default.
• W4205231576 cites W2887144539 @default.
• W4205231576 cites W2895905885 @default.
• W4205231576 cites W2896331213 @default.
• W4205231576 cites W2896761511 @default.
• W4205231576 cites W2897322727 @default.
• W4205231576 cites W2898204381 @default.
• W4205231576 cites W2899780982 @default.
• W4205231576 cites W2903681802 @default.
• W4205231576 cites W2910623991 @default.
• W4205231576 cites W2911251660 @default.
• W4205231576 cites W2913692542 @default.
• W4205231576 cites W2915975309 @default.
• W4205231576 cites W2919262181 @default.
• W4205231576 cites W2922378296 @default.
• W4205231576 cites W2928316994 @default.
• W4205231576 cites W2947011739 @default.
• W4205231576 cites W2948236113 @default.
• W4205231576 cites W3004990755 @default.
• W4205231576 cites W3008835424 @default.
• W4205231576 cites W3010749666 @default.
• W4205231576 cites W3012126351 @default.
• W4205231576 cites W3019607712 @default.
• W4205231576 cites W3084626425 @default.
• W4205231576 cites W3098439125 @default.
• W4205231576 cites W3126740498 @default.
• W4205231576 cites W3128119059 @default.
• W4205231576 cites W3128646645 @default.
• W4205231576 cites W3129163877 @default.
• W4205231576 cites W3132710216 @default.
• W4205231576 cites W3134059314 @default.
• W4205231576 cites W3159239025 @default.
• W4205231576 doi "https://doi.org/10.1016/j.phrs.2022.106080" @default.
• W4205231576 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35032663" @default.
• W4205231576 hasPublicationYear "2022" @default.
• W4205231576 type Work @default.
• W4205231576 citedByCount "11" @default.
• W4205231576 countsByYear W42052315762022 @default.
• W4205231576 countsByYear W42052315762023 @default.
• W4205231576 crossrefType "journal-article" @default.
• W4205231576 hasAuthorship W4205231576A5006349365 @default.
• W4205231576 hasAuthorship W4205231576A5021485446 @default.
• W4205231576 hasAuthorship W4205231576A5025149008 @default.
• W4205231576 hasAuthorship W4205231576A5027640497 @default.
• W4205231576 hasAuthorship W4205231576A5033781225 @default.
• W4205231576 hasAuthorship W4205231576A5042074610 @default.
• W4205231576 hasAuthorship W4205231576A5080513377 @default.
• W4205231576 hasConcept C109316439 @default.
• W4205231576 hasConcept C121608353 @default.
• W4205231576 hasConcept C126322002 @default.
• W4205231576 hasConcept C126511603 @default.
• W4205231576 hasConcept C136229726 @default.
• W4205231576 hasConcept C150903083 @default.
• W4205231576 hasConcept C171250308 @default.
• W4205231576 hasConcept C178790620 @default.
• W4205231576 hasConcept C182606246 @default.
• W4205231576 hasConcept C185592680 @default.
• W4205231576 hasConcept C192562407 @default.
• W4205231576 hasConcept C202751555 @default.
• W4205231576 hasConcept C207001950 @default.
• W4205231576 hasConcept C2776694085 @default.
• W4205231576 hasConcept C2776964284 @default.
• W4205231576 hasConcept C2776999253 @default.
• W4205231576 hasConcept C2777230088 @default.
• W4205231576 hasConcept C2779820397 @default.
• W4205231576 hasConcept C502942594 @default.
• W4205231576 hasConcept C526805850 @default.

• next