FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205251704> ?p ?o ?g. }

• W4205251704 abstract "Dipeptidyl peptidase 4 (DPP4) has been revealed to be upregulated in women suffering from polycystic ovary syndrome (PCOS), which is a common reproductive disorder. The present study was designed to investigate the effects of inhibition of DPP4 expression on the proliferation of ovarian granulosa cells as well as on the activation of the cAMP response element‑binding protein (CREB)/aromatase pathway. The expression levels of DPP4 in rat serum samples with or without PCOS and ovarian granulosa cells (KGN cells) were detected using reverse transcription‑quantitative PCR (RT‑qPCR) and western blot analyses. Cell viability and cell cycle progression were detected using the Cell Counting Kit‑8 assay and flow cytometric analysis, respectively. The 5‑ethynyl‑2'‑deoxyuridine assay was employed to detect the proliferation of glycolaldehyde‑bovine serum albumin (GOA‑BSA)‑treated KGN cells. In addition, RT‑qPCR and western blot analyses were applied to detect the expression levels of CREB, specific cell cycle‑associated proteins and cytochrome P450 (CYP) 19A1 and CYP11A1 enzymes in KGN cells. The expression levels of DPP4 were upregulated in rats with PCOS. Inhibition of DPP4 expression promoted the proliferation and cell cycle arrest of KGN cells. It was also revealed that the expression levels of cell cycle‑associated proteins were upregulated in DPP4‑silenced KGN cells. In addition, their proliferation was decreased following treatment with GOA‑BSA, while the addition of sitagliptin partially reversed these effects. Additionally, sitagliptin reversed the inhibitory effects caused by GOA‑BSA treatment on the cell cycle progression and on the activation of the CREB/aromatase pathway in KGN cells, as determined by the increased expression levels of the cell cycle‑associated proteins as well as those of the CREB protein and the CYP19A1 and CYP11A1 enzymes. In conclusion, inhibition of DPP4 expression promoted the proliferation of KGN cells and the activation of the CREB/aromatase pathway." @default.
• W4205251704 created "2022-01-25" @default.
• W4205251704 creator A5078853139 @default.
• W4205251704 creator A5079447550 @default.
• W4205251704 date "2022-01-07" @default.
• W4205251704 modified "2023-10-05" @default.
• W4205251704 title "Knockdown of DPP4 promotes the proliferation and the activation of the CREB/aromatase pathway in ovarian granulosa cells" @default.
• W4205251704 cites W1970586482 @default.
• W4205251704 cites W1980723366 @default.
• W4205251704 cites W1988293590 @default.
• W4205251704 cites W1990237598 @default.
• W4205251704 cites W2037342776 @default.
• W4205251704 cites W2040635432 @default.
• W4205251704 cites W2046167879 @default.
• W4205251704 cites W2054185381 @default.
• W4205251704 cites W2057313063 @default.
• W4205251704 cites W2062130408 @default.
• W4205251704 cites W2069811052 @default.
• W4205251704 cites W2070387111 @default.
• W4205251704 cites W2106876536 @default.
• W4205251704 cites W2107277218 @default.
• W4205251704 cites W2117559317 @default.
• W4205251704 cites W2119198856 @default.
• W4205251704 cites W2133734610 @default.
• W4205251704 cites W2136003239 @default.
• W4205251704 cites W2139874679 @default.
• W4205251704 cites W2141485678 @default.
• W4205251704 cites W2164216883 @default.
• W4205251704 cites W2172767978 @default.
• W4205251704 cites W2176343920 @default.
• W4205251704 cites W2192080449 @default.
• W4205251704 cites W2249620842 @default.
• W4205251704 cites W2404993778 @default.
• W4205251704 cites W2468859436 @default.
• W4205251704 cites W2536288537 @default.
• W4205251704 cites W2602365829 @default.
• W4205251704 cites W2743822989 @default.
• W4205251704 cites W2753290727 @default.
• W4205251704 cites W2770463350 @default.
• W4205251704 cites W2783691705 @default.
• W4205251704 cites W2797588498 @default.
• W4205251704 cites W2872633888 @default.
• W4205251704 cites W2884316081 @default.
• W4205251704 cites W2890320845 @default.
• W4205251704 cites W2898974403 @default.
• W4205251704 cites W2903244266 @default.
• W4205251704 cites W2913006421 @default.
• W4205251704 cites W2936664042 @default.
• W4205251704 cites W2951509688 @default.
• W4205251704 cites W2969028251 @default.
• W4205251704 cites W29902740 @default.
• W4205251704 cites W2991620808 @default.
• W4205251704 cites W2995488662 @default.
• W4205251704 cites W3005279141 @default.
• W4205251704 cites W3017585151 @default.
• W4205251704 cites W3029449675 @default.
• W4205251704 cites W3037498511 @default.
• W4205251704 cites W3045494870 @default.
• W4205251704 cites W3046621528 @default.
• W4205251704 cites W3081467660 @default.
• W4205251704 cites W3088685410 @default.
• W4205251704 cites W3099082479 @default.
• W4205251704 cites W4242141803 @default.
• W4205251704 cites W4250357365 @default.
• W4205251704 cites W4362175440 @default.
• W4205251704 doi "https://doi.org/10.3892/mmr.2022.12589" @default.
• W4205251704 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35014677" @default.
• W4205251704 hasPublicationYear "2022" @default.
• W4205251704 type Work @default.
• W4205251704 citedByCount "4" @default.
• W4205251704 countsByYear W42052517042022 @default.
• W4205251704 countsByYear W42052517042023 @default.
• W4205251704 crossrefType "journal-article" @default.
• W4205251704 hasAuthorship W4205251704A5078853139 @default.
• W4205251704 hasAuthorship W4205251704A5079447550 @default.
• W4205251704 hasBestOaLocation W42052517041 @default.
• W4205251704 hasConcept C104317684 @default.
• W4205251704 hasConcept C121608353 @default.
• W4205251704 hasConcept C126322002 @default.
• W4205251704 hasConcept C134018914 @default.
• W4205251704 hasConcept C1491633281 @default.
• W4205251704 hasConcept C1629964 @default.
• W4205251704 hasConcept C173396325 @default.
• W4205251704 hasConcept C185592680 @default.
• W4205251704 hasConcept C2776166826 @default.
• W4205251704 hasConcept C2777391703 @default.
• W4205251704 hasConcept C2779306644 @default.
• W4205251704 hasConcept C29537977 @default.
• W4205251704 hasConcept C3018442814 @default.
• W4205251704 hasConcept C530470458 @default.
• W4205251704 hasConcept C54355233 @default.
• W4205251704 hasConcept C55493867 @default.
• W4205251704 hasConcept C62112901 @default.
• W4205251704 hasConcept C71924100 @default.
• W4205251704 hasConcept C81885089 @default.
• W4205251704 hasConcept C86339819 @default.
• W4205251704 hasConcept C86803240 @default.
• W4205251704 hasConceptScore W4205251704C104317684 @default.
• W4205251704 hasConceptScore W4205251704C121608353 @default.
• W4205251704 hasConceptScore W4205251704C126322002 @default.

• next