FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205252203> ?p ?o ?g. }

• W4205252203 abstract "The asparaginase and isoaspartyl peptidase 1 (ASRGL1) is an L-asparaginase and beta-aspartyl peptidase enzyme that may be involved in the formation of L-aspartate, a neurotransmitter that can operate as an excitatory neurotransmitter in some brain regions. Although variants in ASRGL 1 have been reported in retinitis pigmentosa (RP) patients, the in vivo functions and mechanisms of ASRGL in RP remains unknown due to the lack of suitable disease models. To explore the role of ASRGL in RP, we generated an Asrgl1 knockout mouse model ( Asrgl1 KO) using the CRISPR/Cas9 technique. Asrgl1 ablation in mice led to an attenuated electroretinogram (ERG) response around 8 months. The thickness of the outer nuclei layer (ONL) started to decrease around 9 months in Asrgl1 KO mice and gradually intensified at 12 and 15 months. Immunostaining revealed thinner inner segment (IS) and thinner outer segment (OS) as well as the progressive degeneration of rod and cone cells in Asrgl1 KO mice. One hundred forty-nine transcriptional differentially expressed genes (DEGs) were found by RNA-seq in Asrgl1 KO retina. These DEGs were linked to a number of biological processes that were considerably enriched, including gastrointestinal disease and organismal injury and abnormalities. By analysis of canonical pathways, glucocorticoid receptor signaling was the most significant canonical pathway altered in Asrgl1 KO retina. Several molecules, including NFE2L2, IL-4, Foxp3, and Fos, were in the central nodes of the interaction network in Asrgl1 KO retina. In summary, our study provided a knockout mouse model for a better understanding of the molecular mechanism for ASRGL1 -related RP." @default.
• W4205252203 created "2022-01-25" @default.
• W4205252203 creator A5020153635 @default.
• W4205252203 creator A5026216205 @default.
• W4205252203 creator A5027997220 @default.
• W4205252203 creator A5032030472 @default.
• W4205252203 creator A5037634210 @default.
• W4205252203 creator A5046233977 @default.
• W4205252203 creator A5056614628 @default.
• W4205252203 creator A5068508411 @default.
• W4205252203 creator A5081307254 @default.
• W4205252203 creator A5086074026 @default.
• W4205252203 creator A5088963935 @default.
• W4205252203 date "2022-01-18" @default.
• W4205252203 modified "2023-10-12" @default.
• W4205252203 title "Deletion of Asrgl1 Leads to Photoreceptor Degeneration in Mice" @default.
• W4205252203 cites W1503104403 @default.
• W4205252203 cites W1968261842 @default.
• W4205252203 cites W1969249989 @default.
• W4205252203 cites W1977823409 @default.
• W4205252203 cites W1997660876 @default.
• W4205252203 cites W1997927831 @default.
• W4205252203 cites W2020293242 @default.
• W4205252203 cites W2029584153 @default.
• W4205252203 cites W2034836489 @default.
• W4205252203 cites W2056582616 @default.
• W4205252203 cites W2057917694 @default.
• W4205252203 cites W2068497129 @default.
• W4205252203 cites W2096083683 @default.
• W4205252203 cites W2102267006 @default.
• W4205252203 cites W2128166968 @default.
• W4205252203 cites W2133415315 @default.
• W4205252203 cites W2146199659 @default.
• W4205252203 cites W2150132566 @default.
• W4205252203 cites W2150823208 @default.
• W4205252203 cites W2160119905 @default.
• W4205252203 cites W2336509285 @default.
• W4205252203 cites W2418970523 @default.
• W4205252203 cites W2563497525 @default.
• W4205252203 cites W2610933369 @default.
• W4205252203 cites W2726430797 @default.
• W4205252203 cites W2760260836 @default.
• W4205252203 cites W2765080153 @default.
• W4205252203 cites W2767842916 @default.
• W4205252203 cites W2788838846 @default.
• W4205252203 cites W3128475302 @default.
• W4205252203 cites W4211099883 @default.
• W4205252203 doi "https://doi.org/10.3389/fcell.2021.783547" @default.
• W4205252203 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35118070" @default.
• W4205252203 hasPublicationYear "2022" @default.
• W4205252203 type Work @default.
• W4205252203 citedByCount "3" @default.
• W4205252203 countsByYear W42052522032022 @default.
• W4205252203 countsByYear W42052522032023 @default.
• W4205252203 crossrefType "journal-article" @default.
• W4205252203 hasAuthorship W4205252203A5020153635 @default.
• W4205252203 hasAuthorship W4205252203A5026216205 @default.
• W4205252203 hasAuthorship W4205252203A5027997220 @default.
• W4205252203 hasAuthorship W4205252203A5032030472 @default.
• W4205252203 hasAuthorship W4205252203A5037634210 @default.
• W4205252203 hasAuthorship W4205252203A5046233977 @default.
• W4205252203 hasAuthorship W4205252203A5056614628 @default.
• W4205252203 hasAuthorship W4205252203A5068508411 @default.
• W4205252203 hasAuthorship W4205252203A5081307254 @default.
• W4205252203 hasAuthorship W4205252203A5086074026 @default.
• W4205252203 hasAuthorship W4205252203A5088963935 @default.
• W4205252203 hasBestOaLocation W42052522031 @default.
• W4205252203 hasConcept C103796816 @default.
• W4205252203 hasConcept C104317684 @default.
• W4205252203 hasConcept C126322002 @default.
• W4205252203 hasConcept C134018914 @default.
• W4205252203 hasConcept C169760540 @default.
• W4205252203 hasConcept C170493617 @default.
• W4205252203 hasConcept C173396325 @default.
• W4205252203 hasConcept C182704531 @default.
• W4205252203 hasConcept C203014093 @default.
• W4205252203 hasConcept C204232928 @default.
• W4205252203 hasConcept C2776219046 @default.
• W4205252203 hasConcept C2777093970 @default.
• W4205252203 hasConcept C2778231335 @default.
• W4205252203 hasConcept C2781040256 @default.
• W4205252203 hasConcept C2781114197 @default.
• W4205252203 hasConcept C4224716 @default.
• W4205252203 hasConcept C529278444 @default.
• W4205252203 hasConcept C54355233 @default.
• W4205252203 hasConcept C71924100 @default.
• W4205252203 hasConcept C86803240 @default.
• W4205252203 hasConcept C95444343 @default.
• W4205252203 hasConceptScore W4205252203C103796816 @default.
• W4205252203 hasConceptScore W4205252203C104317684 @default.
• W4205252203 hasConceptScore W4205252203C126322002 @default.
• W4205252203 hasConceptScore W4205252203C134018914 @default.
• W4205252203 hasConceptScore W4205252203C169760540 @default.
• W4205252203 hasConceptScore W4205252203C170493617 @default.
• W4205252203 hasConceptScore W4205252203C173396325 @default.
• W4205252203 hasConceptScore W4205252203C182704531 @default.
• W4205252203 hasConceptScore W4205252203C203014093 @default.
• W4205252203 hasConceptScore W4205252203C204232928 @default.
• W4205252203 hasConceptScore W4205252203C2776219046 @default.
• W4205252203 hasConceptScore W4205252203C2777093970 @default.

• next