Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205252592> ?p ?o ?g. }
- W4205252592 endingPage "510" @default.
- W4205252592 startingPage "510" @default.
- W4205252592 abstract "In recent years, the immune system has emerged as a critical regulator of tumor development, progression and dissemination. Advanced therapeutic approaches targeting immune cells are currently under clinical use and improvement for the treatment of patients affected by advanced malignancies. Among these, anti-PD1/PD-L1 and anti-CTLA4 immune checkpoint inhibitors (ICIs) are the most effective immunotherapeutic drugs at present. In spite of these advances, great variability in responses to therapy exists among patients, probably due to the heterogeneity of both cancer cells and immune responses, which manifest in diverse forms in the tumor microenvironment (TME). The variability of the immune profile within TME and its prognostic significance largely depend on the frequency of the infiltrating myeloid cells, which often represent the predominant population, characterized by high phenotypic heterogeneity. The generation of heterogeneous myeloid populations endowed with tumor-promoting activities is typically promoted by growing tumors, indicating the sequential levels of myeloid reprogramming as possible antitumor targets. This work reviews the current knowledge on the events governing protumoral myelopoiesis, analyzing the mechanisms that drive the expansion of major myeloid subsets, as well as their functional properties, and highlighting recent translational strategies for clinical developments." @default.
- W4205252592 created "2022-01-25" @default.
- W4205252592 creator A5021119674 @default.
- W4205252592 creator A5021701467 @default.
- W4205252592 creator A5027311900 @default.
- W4205252592 creator A5070789136 @default.
- W4205252592 creator A5072343108 @default.
- W4205252592 date "2022-01-20" @default.
- W4205252592 modified "2023-10-09" @default.
- W4205252592 title "Evolution and Targeting of Myeloid Suppressor Cells in Cancer: A Translational Perspective" @default.
- W4205252592 cites W1010975229 @default.
- W4205252592 cites W1519912445 @default.
- W4205252592 cites W1616217811 @default.
- W4205252592 cites W1877245175 @default.
- W4205252592 cites W1921451985 @default.
- W4205252592 cites W1927075449 @default.
- W4205252592 cites W1963904011 @default.
- W4205252592 cites W1966217032 @default.
- W4205252592 cites W1969057487 @default.
- W4205252592 cites W1972835138 @default.
- W4205252592 cites W1976556343 @default.
- W4205252592 cites W1980485314 @default.
- W4205252592 cites W1984618863 @default.
- W4205252592 cites W1985102142 @default.
- W4205252592 cites W1986957385 @default.
- W4205252592 cites W1987255100 @default.
- W4205252592 cites W1989673842 @default.
- W4205252592 cites W1990218923 @default.
- W4205252592 cites W2002157461 @default.
- W4205252592 cites W2004445332 @default.
- W4205252592 cites W2011615632 @default.
- W4205252592 cites W2012136117 @default.
- W4205252592 cites W2017056838 @default.
- W4205252592 cites W2023917164 @default.
- W4205252592 cites W2025129645 @default.
- W4205252592 cites W2027607692 @default.
- W4205252592 cites W2033278321 @default.
- W4205252592 cites W2040662877 @default.
- W4205252592 cites W2043991982 @default.
- W4205252592 cites W2046485697 @default.
- W4205252592 cites W2046905172 @default.
- W4205252592 cites W2047902191 @default.
- W4205252592 cites W2055207393 @default.
- W4205252592 cites W2060672294 @default.
- W4205252592 cites W2062873927 @default.
- W4205252592 cites W2067067271 @default.
- W4205252592 cites W2067740832 @default.
- W4205252592 cites W2070855360 @default.
- W4205252592 cites W2071959986 @default.
- W4205252592 cites W2076743146 @default.
- W4205252592 cites W2086908240 @default.
- W4205252592 cites W2096616470 @default.
- W4205252592 cites W2106926972 @default.
- W4205252592 cites W2109978756 @default.
- W4205252592 cites W2112940058 @default.
- W4205252592 cites W2114017759 @default.
- W4205252592 cites W2114737175 @default.
- W4205252592 cites W2123870112 @default.
- W4205252592 cites W2125251487 @default.
- W4205252592 cites W2126020984 @default.
- W4205252592 cites W2129338773 @default.
- W4205252592 cites W2134069241 @default.
- W4205252592 cites W2138326965 @default.
- W4205252592 cites W2144156694 @default.
- W4205252592 cites W2149639441 @default.
- W4205252592 cites W2153232526 @default.
- W4205252592 cites W2154983077 @default.
- W4205252592 cites W2158853057 @default.
- W4205252592 cites W2159560463 @default.
- W4205252592 cites W2160229573 @default.
- W4205252592 cites W2175766278 @default.
- W4205252592 cites W2193074466 @default.
- W4205252592 cites W2193887682 @default.
- W4205252592 cites W2213790033 @default.
- W4205252592 cites W2237361742 @default.
- W4205252592 cites W2317575649 @default.
- W4205252592 cites W2332292689 @default.
- W4205252592 cites W2341289486 @default.
- W4205252592 cites W2343868815 @default.
- W4205252592 cites W2403473377 @default.
- W4205252592 cites W2411767313 @default.
- W4205252592 cites W2414840542 @default.
- W4205252592 cites W2465158514 @default.
- W4205252592 cites W2468925656 @default.
- W4205252592 cites W2471500324 @default.
- W4205252592 cites W2472961609 @default.
- W4205252592 cites W2474950788 @default.
- W4205252592 cites W2488076079 @default.
- W4205252592 cites W2501488762 @default.
- W4205252592 cites W2516944689 @default.
- W4205252592 cites W2520601585 @default.
- W4205252592 cites W2523973428 @default.
- W4205252592 cites W2533098748 @default.
- W4205252592 cites W2534066964 @default.
- W4205252592 cites W2537146822 @default.
- W4205252592 cites W2548633484 @default.
- W4205252592 cites W2549204228 @default.
- W4205252592 cites W2552470435 @default.