FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205256768> ?p ?o ?g. }

• W4205256768 endingPage "101012" @default.
• W4205256768 startingPage "101012" @default.
• W4205256768 abstract "Physical exercise induces important system disturbances in the human body in a dose-response manner. Meta-analyses of genome-wide expression studies (GWES) might contribute to identify gene expression patterns and to a better understanding of the molecular mechanisms behind the complexity of adaptations to exercise, under a systems biology approach. Here, we aimed to analyze available data for human GWES that have evaluated the effect of exhaustive exercise in peripheral blood mononuclear cells (PBMC) and white blood cells (WBC). Three primary datasets retrieved from the NCBI Gene Expression Omnibus were meta-analyzed using a random effects model in the NetworkAnalyst software. After identifying nine differentially expressed genes (DEGs), we performed functional enrichment analyses to extract relevant biological information. A protein-protein interactions network on DEGs was built to evaluate the associated regulatory pathways. We found that five upregulated genes were members of the heat shock protein family, one of the top stress-response groups of genes. The enrichment analysis revealed key roles of the DEGs on the cellular adaptations to exercise-induced stress (i.e., temperature stimulus, topologically-incorrect and unfolded proteins). Our comparison analysis of DEG signatures found in blood cells with the expression pattern on muscle skeletal tissue showed some common genes. Thus, novel DEGs that might serve as hormetic mediators to exercise-induced adaptations were identified. Further experimental research is needed to validate these findings." @default.
• W4205256768 created "2022-01-25" @default.
• W4205256768 creator A5003053770 @default.
• W4205256768 creator A5003405857 @default.
• W4205256768 creator A5069292492 @default.
• W4205256768 creator A5069318012 @default.
• W4205256768 date "2022-02-01" @default.
• W4205256768 modified "2023-09-28" @default.
• W4205256768 title "An in silico analysis of genome-wide expression profiles of the effects of exhaustive exercise identifies heat shock proteins as the key players" @default.
• W4205256768 cites W1983519967 @default.
• W4205256768 cites W1988603298 @default.
• W4205256768 cites W2000490904 @default.
• W4205256768 cites W2008950282 @default.
• W4205256768 cites W2012470325 @default.
• W4205256768 cites W2020942835 @default.
• W4205256768 cites W2027982572 @default.
• W4205256768 cites W2055422299 @default.
• W4205256768 cites W2081375228 @default.
• W4205256768 cites W2092609958 @default.
• W4205256768 cites W2098853434 @default.
• W4205256768 cites W2109141141 @default.
• W4205256768 cites W2125897199 @default.
• W4205256768 cites W2126200849 @default.
• W4205256768 cites W2129257630 @default.
• W4205256768 cites W2136086564 @default.
• W4205256768 cites W2140930673 @default.
• W4205256768 cites W2144652377 @default.
• W4205256768 cites W2145422153 @default.
• W4205256768 cites W2152169346 @default.
• W4205256768 cites W2154981570 @default.
• W4205256768 cites W2158217645 @default.
• W4205256768 cites W2159675211 @default.
• W4205256768 cites W2172133801 @default.
• W4205256768 cites W2235806863 @default.
• W4205256768 cites W2265991227 @default.
• W4205256768 cites W2298610985 @default.
• W4205256768 cites W2328020939 @default.
• W4205256768 cites W2335965827 @default.
• W4205256768 cites W2399049602 @default.
• W4205256768 cites W2416243378 @default.
• W4205256768 cites W2431575019 @default.
• W4205256768 cites W2474747771 @default.
• W4205256768 cites W2567872373 @default.
• W4205256768 cites W2652103234 @default.
• W4205256768 cites W2734579447 @default.
• W4205256768 cites W2746103056 @default.
• W4205256768 cites W2811153526 @default.
• W4205256768 cites W2854037000 @default.
• W4205256768 cites W2902555929 @default.
• W4205256768 cites W2911413878 @default.
• W4205256768 cites W2921185850 @default.
• W4205256768 cites W2935024989 @default.
• W4205256768 cites W2935861759 @default.
• W4205256768 cites W2944960005 @default.
• W4205256768 cites W2945895035 @default.
• W4205256768 cites W2955058279 @default.
• W4205256768 cites W2974485100 @default.
• W4205256768 cites W3002380642 @default.
• W4205256768 cites W3021494426 @default.
• W4205256768 cites W3036414469 @default.
• W4205256768 cites W3116150149 @default.
• W4205256768 cites W3121532810 @default.
• W4205256768 cites W3128025687 @default.
• W4205256768 cites W3134367013 @default.
• W4205256768 cites W3137348698 @default.
• W4205256768 cites W3150911920 @default.
• W4205256768 cites W3154227689 @default.
• W4205256768 cites W3168414855 @default.
• W4205256768 cites W3197849042 @default.
• W4205256768 doi "https://doi.org/10.1016/j.mgene.2022.101012" @default.
• W4205256768 hasPublicationYear "2022" @default.
• W4205256768 type Work @default.
• W4205256768 citedByCount "1" @default.
• W4205256768 countsByYear W42052567682023 @default.
• W4205256768 crossrefType "journal-article" @default.
• W4205256768 hasAuthorship W4205256768A5003053770 @default.
• W4205256768 hasAuthorship W4205256768A5003405857 @default.
• W4205256768 hasAuthorship W4205256768A5069292492 @default.
• W4205256768 hasAuthorship W4205256768A5069318012 @default.
• W4205256768 hasConcept C104317684 @default.
• W4205256768 hasConcept C137984847 @default.
• W4205256768 hasConcept C141231307 @default.
• W4205256768 hasConcept C150194340 @default.
• W4205256768 hasConcept C18431079 @default.
• W4205256768 hasConcept C205260736 @default.
• W4205256768 hasConcept C2775905019 @default.
• W4205256768 hasConcept C54355233 @default.
• W4205256768 hasConcept C60644358 @default.
• W4205256768 hasConcept C68991219 @default.
• W4205256768 hasConcept C70721500 @default.
• W4205256768 hasConcept C86803240 @default.
• W4205256768 hasConceptScore W4205256768C104317684 @default.
• W4205256768 hasConceptScore W4205256768C137984847 @default.
• W4205256768 hasConceptScore W4205256768C141231307 @default.
• W4205256768 hasConceptScore W4205256768C150194340 @default.
• W4205256768 hasConceptScore W4205256768C18431079 @default.
• W4205256768 hasConceptScore W4205256768C205260736 @default.
• W4205256768 hasConceptScore W4205256768C2775905019 @default.

• next