Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205268075> ?p ?o ?g. }
- W4205268075 endingPage "2699" @default.
- W4205268075 startingPage "2686" @default.
- W4205268075 abstract "Antiplatelet medications remain a cornerstone of therapy for atherosclerotic cardiovascular and cerebrovascular diseases. In primary prevention (patients with cardiovascular risk factors but no documented events, symptoms or angiographic disease), there is little evidence of benefit of any antiplatelet therapy, and such therapy carries the risk of excess bleeding. Where there is documented disease (secondary prevention), stable patients benefit from long‐term antiplatelet monotherapy, aspirin being first choice in those with coronary heart disease and clopidogrel in those with cerebrovascular disease; moreover, recent evidence shows that low‐dose rivaroxaban in combination with aspirin confers added benefit, in patients with stable cardiovascular and peripheral arterial disease. In patients with acute cerebrovascular disease, aspirin combined with clopidogrel reduces subsequent risk, while in acute coronary syndrome, dual antiplatelet therapy comprising aspirin and a P2Y 12 inhibitor (clopidogrel, prasugrel or ticagrelor) confers greater protection than aspirin monotherapy, with prasugrel and ticagrelor offering greater antiplatelet efficacy with faster onset of action than clopidogrel. Although greater antiplatelet efficacy is advantageous in preventing thrombotic events, this must be tempered by increased risk of bleeding, which may be a particular issue in certain patient groups, as will be discussed. We will also discuss possible future approaches to personalisation of antiplatelet therapy." @default.
- W4205268075 created "2022-01-25" @default.
- W4205268075 creator A5042353254 @default.
- W4205268075 creator A5045722303 @default.
- W4205268075 creator A5062214319 @default.
- W4205268075 creator A5086723819 @default.
- W4205268075 date "2022-02-03" @default.
- W4205268075 modified "2023-10-05" @default.
- W4205268075 title "Antiplatelet therapy in cardiovascular disease: Current status and future directions" @default.
- W4205268075 cites W10734288 @default.
- W4205268075 cites W144700851 @default.
- W4205268075 cites W1480729244 @default.
- W4205268075 cites W1498265361 @default.
- W4205268075 cites W191849520 @default.
- W4205268075 cites W1937194701 @default.
- W4205268075 cites W1966737506 @default.
- W4205268075 cites W1976361153 @default.
- W4205268075 cites W1985059672 @default.
- W4205268075 cites W1985835171 @default.
- W4205268075 cites W1991655882 @default.
- W4205268075 cites W2001688139 @default.
- W4205268075 cites W2026458612 @default.
- W4205268075 cites W2028586794 @default.
- W4205268075 cites W2068731335 @default.
- W4205268075 cites W2081615170 @default.
- W4205268075 cites W2093814225 @default.
- W4205268075 cites W2095502107 @default.
- W4205268075 cites W2098458064 @default.
- W4205268075 cites W2100089051 @default.
- W4205268075 cites W2100209149 @default.
- W4205268075 cites W2100928282 @default.
- W4205268075 cites W2107797912 @default.
- W4205268075 cites W2108817878 @default.
- W4205268075 cites W2117677020 @default.
- W4205268075 cites W2119345183 @default.
- W4205268075 cites W2120544643 @default.
- W4205268075 cites W2125173296 @default.
- W4205268075 cites W2132129910 @default.
- W4205268075 cites W2132247347 @default.
- W4205268075 cites W2140501627 @default.
- W4205268075 cites W2141358924 @default.
- W4205268075 cites W2144194629 @default.
- W4205268075 cites W2150959326 @default.
- W4205268075 cites W2154940301 @default.
- W4205268075 cites W2157833432 @default.
- W4205268075 cites W2164386459 @default.
- W4205268075 cites W2169387542 @default.
- W4205268075 cites W2287540005 @default.
- W4205268075 cites W2361921955 @default.
- W4205268075 cites W2397867274 @default.
- W4205268075 cites W2461718870 @default.
- W4205268075 cites W2509918966 @default.
- W4205268075 cites W2546593930 @default.
- W4205268075 cites W2548744167 @default.
- W4205268075 cites W2556414715 @default.
- W4205268075 cites W2748517697 @default.
- W4205268075 cites W2749380187 @default.
- W4205268075 cites W2766845216 @default.
- W4205268075 cites W2779726076 @default.
- W4205268075 cites W2785279414 @default.
- W4205268075 cites W2788079067 @default.
- W4205268075 cites W2791656192 @default.
- W4205268075 cites W2804570339 @default.
- W4205268075 cites W2885658558 @default.
- W4205268075 cites W2888108651 @default.
- W4205268075 cites W2888458270 @default.
- W4205268075 cites W2892288854 @default.
- W4205268075 cites W2899755710 @default.
- W4205268075 cites W2921724943 @default.
- W4205268075 cites W2931257824 @default.
- W4205268075 cites W2943516261 @default.
- W4205268075 cites W2946195567 @default.
- W4205268075 cites W2948570007 @default.
- W4205268075 cites W2953479758 @default.
- W4205268075 cites W2955952534 @default.
- W4205268075 cites W2969273075 @default.
- W4205268075 cites W2970797239 @default.
- W4205268075 cites W2971019453 @default.
- W4205268075 cites W2971165578 @default.
- W4205268075 cites W2971992346 @default.
- W4205268075 cites W2976166882 @default.
- W4205268075 cites W2979817571 @default.
- W4205268075 cites W2984194970 @default.
- W4205268075 cites W2987819628 @default.
- W4205268075 cites W2991016007 @default.
- W4205268075 cites W3011371150 @default.
- W4205268075 cites W3013428853 @default.
- W4205268075 cites W3019423044 @default.
- W4205268075 cites W3035351100 @default.
- W4205268075 cites W3043492355 @default.
- W4205268075 cites W3110213440 @default.
- W4205268075 cites W311320695 @default.
- W4205268075 cites W3136867187 @default.
- W4205268075 cites W3162195278 @default.
- W4205268075 cites W3163845177 @default.
- W4205268075 cites W4205268075 @default.
- W4205268075 cites W4290749263 @default.
- W4205268075 cites W4298311999 @default.