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- W4205279944 endingPage "1258" @default.
- W4205279944 startingPage "1235" @default.
- W4205279944 abstract "Abstract Schwann cells (SCs) are fundamental components of the peripheral nervous system (PNS) of all vertebrates and play essential roles in development, maintenance, function, and regeneration of peripheral nerves. There are distinct populations of SCs including: (1) myelinating SCs that ensheath axons by a specialized plasma membrane, called myelin, which enhances the conduction of electric impulses; (2) non‐myelinating SCs, including Remak SCs, which wrap bundles of multiple axons of small caliber, and perysinaptic SCs (PSCs), associated with motor axon terminals at the neuromuscular junction (NMJ). All types of SCs contribute to PNS regeneration through striking morphological and functional changes in response to nerve injury, are affected in peripheral neuropathies and show abnormalities and a diminished plasticity during aging. Therefore, methodological approaches to study and manipulate SCs in physiological and pathophysiological conditions are crucial to expand the present knowledge on SC biology and to devise new therapeutic strategies to counteract neurodegenerative conditions and age‐derived denervation. We present here an updated overview of traditional and emerging methodologies for the study of SCs for scientists approaching this research field." @default.
- W4205279944 created "2022-01-25" @default.
- W4205279944 creator A5010509601 @default.
- W4205279944 creator A5022481320 @default.
- W4205279944 creator A5084488513 @default.
- W4205279944 date "2022-01-05" @default.
- W4205279944 modified "2023-09-30" @default.
- W4205279944 title "Models and methods to study Schwann cells" @default.
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