FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205280343> ?p ?o ?g. }

• W4205280343 abstract "Objective: Aging is the major risk factor for human cancers, including rectal cancer. Targeting the aging process provides broad-spectrum protection against cancers. Here, we investigate the clinical implications of aging-related genes in rectal cancer. Methods: Dysregulated aging-related genes were screened in rectal cancer from TCGA project. A LASSO prognostic model was conducted, and the predictive performance was evaluated and externally verified in the GEO data set. Associations of the model with tumor-infiltrating immune cells, immune and stromal score, HLA and immune checkpoints, and response to chemotherapeutic agents were analyzed across rectal cancer. Biological processes underlying the model were investigated through GSVA and GSEA methods. Doxorubicin (DOX)-induced or replicative senescent stromal cells were constructed, and AGTR1 was silenced in HUVECs. After coculture with conditioned medium of HUVECs, rectal cancer cell growth and invasion were investigated. Results: An aging-related model was established, consisting of KL, BRCA1, CLU, and AGTR1, which can stratify high- and low-risk patients in terms of overall survival, disease-free survival, and progression-free interval. ROC and Cox regression analyses confirmed that the model was a robust and independent predictor. Furthermore, it was in relation to tumor immunity and stromal activation as well as predicted the responses to gemcitabine and sunitinib. AGTR1 knockdown ameliorated stromal cell senescence and suppressed senescent stromal cell-triggered rectal cancer progression. Conclusion: Our findings suggest that the aging-related gene signature was in relation to tumor immunity and stromal activation in rectal cancer, which might predict survival outcomes and immuno- and chemotherapy benefits." @default.
• W4205280343 created "2022-01-25" @default.
• W4205280343 creator A5017718255 @default.
• W4205280343 creator A5017917541 @default.
• W4205280343 creator A5027334799 @default.
• W4205280343 creator A5039242472 @default.
• W4205280343 creator A5046173951 @default.
• W4205280343 date "2022-01-10" @default.
• W4205280343 modified "2023-10-01" @default.
• W4205280343 title "Development of an Aging-Related Gene Signature for Predicting Prognosis, Immunotherapy, and Chemotherapy Benefits in Rectal Cancer" @default.
• W4205280343 cites W1829914012 @default.
• W4205280343 cites W2035618305 @default.
• W4205280343 cites W2075294566 @default.
• W4205280343 cites W2108068107 @default.
• W4205280343 cites W2114843025 @default.
• W4205280343 cites W2121604817 @default.
• W4205280343 cites W2123879591 @default.
• W4205280343 cites W2126525177 @default.
• W4205280343 cites W2130410032 @default.
• W4205280343 cites W2130430382 @default.
• W4205280343 cites W2131856634 @default.
• W4205280343 cites W2146512944 @default.
• W4205280343 cites W2159707944 @default.
• W4205280343 cites W2214074259 @default.
• W4205280343 cites W2230320310 @default.
• W4205280343 cites W2289712604 @default.
• W4205280343 cites W2551911481 @default.
• W4205280343 cites W2767517408 @default.
• W4205280343 cites W2768033029 @default.
• W4205280343 cites W2785803176 @default.
• W4205280343 cites W2895020581 @default.
• W4205280343 cites W2908922892 @default.
• W4205280343 cites W2949273159 @default.
• W4205280343 cites W2949821018 @default.
• W4205280343 cites W2955233209 @default.
• W4205280343 cites W2969705573 @default.
• W4205280343 cites W3011356804 @default.
• W4205280343 cites W3035917003 @default.
• W4205280343 cites W3043602140 @default.
• W4205280343 cites W3091847303 @default.
• W4205280343 cites W3092179751 @default.
• W4205280343 cites W3108007178 @default.
• W4205280343 cites W3113150059 @default.
• W4205280343 cites W3133729612 @default.
• W4205280343 cites W3139390001 @default.
• W4205280343 cites W3170140713 @default.
• W4205280343 doi "https://doi.org/10.3389/fmolb.2021.775700" @default.
• W4205280343 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35083278" @default.
• W4205280343 hasPublicationYear "2022" @default.
• W4205280343 type Work @default.
• W4205280343 citedByCount "4" @default.
• W4205280343 countsByYear W42052803432022 @default.
• W4205280343 countsByYear W42052803432023 @default.
• W4205280343 crossrefType "journal-article" @default.
• W4205280343 hasAuthorship W4205280343A5017718255 @default.
• W4205280343 hasAuthorship W4205280343A5017917541 @default.
• W4205280343 hasAuthorship W4205280343A5027334799 @default.
• W4205280343 hasAuthorship W4205280343A5039242472 @default.
• W4205280343 hasAuthorship W4205280343A5046173951 @default.
• W4205280343 hasBestOaLocation W42052803431 @default.
• W4205280343 hasConcept C104317684 @default.
• W4205280343 hasConcept C121608353 @default.
• W4205280343 hasConcept C126322002 @default.
• W4205280343 hasConcept C143998085 @default.
• W4205280343 hasConcept C150194340 @default.
• W4205280343 hasConcept C16930146 @default.
• W4205280343 hasConcept C203014093 @default.
• W4205280343 hasConcept C2777701055 @default.
• W4205280343 hasConcept C2779733811 @default.
• W4205280343 hasConcept C502942594 @default.
• W4205280343 hasConcept C526805850 @default.
• W4205280343 hasConcept C55493867 @default.
• W4205280343 hasConcept C71924100 @default.
• W4205280343 hasConcept C86803240 @default.
• W4205280343 hasConcept C8891405 @default.
• W4205280343 hasConceptScore W4205280343C104317684 @default.
• W4205280343 hasConceptScore W4205280343C121608353 @default.
• W4205280343 hasConceptScore W4205280343C126322002 @default.
• W4205280343 hasConceptScore W4205280343C143998085 @default.
• W4205280343 hasConceptScore W4205280343C150194340 @default.
• W4205280343 hasConceptScore W4205280343C16930146 @default.
• W4205280343 hasConceptScore W4205280343C203014093 @default.
• W4205280343 hasConceptScore W4205280343C2777701055 @default.
• W4205280343 hasConceptScore W4205280343C2779733811 @default.
• W4205280343 hasConceptScore W4205280343C502942594 @default.
• W4205280343 hasConceptScore W4205280343C526805850 @default.
• W4205280343 hasConceptScore W4205280343C55493867 @default.
• W4205280343 hasConceptScore W4205280343C71924100 @default.
• W4205280343 hasConceptScore W4205280343C86803240 @default.
• W4205280343 hasConceptScore W4205280343C8891405 @default.
• W4205280343 hasLocation W42052803431 @default.
• W4205280343 hasLocation W42052803432 @default.
• W4205280343 hasLocation W42052803433 @default.
• W4205280343 hasLocation W42052803434 @default.
• W4205280343 hasOpenAccess W4205280343 @default.
• W4205280343 hasPrimaryLocation W42052803431 @default.
• W4205280343 hasRelatedWork W1573445593 @default.
• W4205280343 hasRelatedWork W1996150995 @default.
• W4205280343 hasRelatedWork W2052752700 @default.
• W4205280343 hasRelatedWork W3004259476 @default.

• next