Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205282937> ?p ?o ?g. }
- W4205282937 endingPage "314" @default.
- W4205282937 startingPage "304" @default.
- W4205282937 abstract "Combining solid phase microextraction (SPME) and mass spectrometry (MS) analysis has become increasingly important to many bioanalytical, environmental, and forensic applications due to its simplicity, rapid analysis, and capability of reducing matrix effects for complex samples. To further promote the adoption of SPME-MS based analysis and expand its application scope calls for efficient and convenient interfaces that couple the SPME sample handling with the efficient analyte ionization for MS. Here, we report a novel interface that integrates both the desorption and the ionization steps in one device based on the capillary vibrating sharp-edge spray ionization (cVSSI) method. We demonstrated that the cVSSI is capable of nebulizing liquid samples in a pulled-tip glass capillary with a battery powered function generator. The cVSSI device allows the insertion of a SPME probe into the spray capillary for desorption and then direct nebulization of the desorption solvent in situ. With the integrated interface, we have demonstrated rapid MS analysis of drug compounds from serum samples. Quantitative determination of various drug compounds including metoprolol, pindolol, acebutolol, oxprenolol, capecitabine, and irinotecan was achieved with good linearity (R2 = 0.97–0.99) and limit of detection ranging from 0.25 to 0.59 ng/mL without using a high voltage source. Only 3.5 μL of desorption solvent and 3 min desorption time were needed for the present method. Overall, we demonstrated a portable SPME-MS interface featuring high sensitivity, short analysis time, small footprint, and low cost, which makes it an attractive method for many applications requiring sample cleanup including drug compound monitoring, environmental sample analysis, and forensic sample analysis." @default.
- W4205282937 created "2022-01-26" @default.
- W4205282937 creator A5037677450 @default.
- W4205282937 creator A5052361307 @default.
- W4205282937 creator A5078039628 @default.
- W4205282937 date "2022-01-18" @default.
- W4205282937 modified "2023-09-25" @default.
- W4205282937 title "A Small Footprint and Robust Interface for Solid Phase Microextraction and Mass Spectrometry Based on Vibrating Sharp-Edge Spray Ionization" @default.
- W4205282937 cites W1506602450 @default.
- W4205282937 cites W1865438961 @default.
- W4205282937 cites W1974011923 @default.
- W4205282937 cites W1982991226 @default.
- W4205282937 cites W1984771004 @default.
- W4205282937 cites W1986952772 @default.
- W4205282937 cites W1987308636 @default.
- W4205282937 cites W1990548330 @default.
- W4205282937 cites W1990594045 @default.
- W4205282937 cites W1991641346 @default.
- W4205282937 cites W1992383300 @default.
- W4205282937 cites W1996206796 @default.
- W4205282937 cites W1998258947 @default.
- W4205282937 cites W2002874506 @default.
- W4205282937 cites W2006337148 @default.
- W4205282937 cites W2006971413 @default.
- W4205282937 cites W2007455664 @default.
- W4205282937 cites W2023167127 @default.
- W4205282937 cites W2023194850 @default.
- W4205282937 cites W2031035470 @default.
- W4205282937 cites W2047108695 @default.
- W4205282937 cites W2051118703 @default.
- W4205282937 cites W2052474968 @default.
- W4205282937 cites W2053870335 @default.
- W4205282937 cites W2055057794 @default.
- W4205282937 cites W2056643242 @default.
- W4205282937 cites W2065213535 @default.
- W4205282937 cites W2067353276 @default.
- W4205282937 cites W2075872235 @default.
- W4205282937 cites W2079777604 @default.
- W4205282937 cites W2088368207 @default.
- W4205282937 cites W2092876801 @default.
- W4205282937 cites W2093643731 @default.
- W4205282937 cites W2101936201 @default.
- W4205282937 cites W2102116742 @default.
- W4205282937 cites W2110413022 @default.
- W4205282937 cites W2123279277 @default.
- W4205282937 cites W2123604609 @default.
- W4205282937 cites W2135481505 @default.
- W4205282937 cites W2143927089 @default.
- W4205282937 cites W2151305937 @default.
- W4205282937 cites W2157520165 @default.
- W4205282937 cites W2171344995 @default.
- W4205282937 cites W2188305313 @default.
- W4205282937 cites W2212688122 @default.
- W4205282937 cites W2238296660 @default.
- W4205282937 cites W2252459946 @default.
- W4205282937 cites W2321108437 @default.
- W4205282937 cites W2327370663 @default.
- W4205282937 cites W247840637 @default.
- W4205282937 cites W2769885370 @default.
- W4205282937 cites W2786143781 @default.
- W4205282937 cites W2802091465 @default.
- W4205282937 cites W2829097635 @default.
- W4205282937 cites W2889703958 @default.
- W4205282937 cites W2897196791 @default.
- W4205282937 cites W2902146322 @default.
- W4205282937 cites W2915366856 @default.
- W4205282937 cites W2920978012 @default.
- W4205282937 cites W2921336398 @default.
- W4205282937 cites W2943969166 @default.
- W4205282937 cites W2944985444 @default.
- W4205282937 cites W2955595879 @default.
- W4205282937 cites W3000429282 @default.
- W4205282937 cites W3093442812 @default.
- W4205282937 cites W3103895141 @default.
- W4205282937 doi "https://doi.org/10.1021/jasms.1c00305" @default.
- W4205282937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35040644" @default.
- W4205282937 hasPublicationYear "2022" @default.
- W4205282937 type Work @default.
- W4205282937 citedByCount "6" @default.
- W4205282937 countsByYear W42052829372022 @default.
- W4205282937 countsByYear W42052829372023 @default.
- W4205282937 crossrefType "journal-article" @default.
- W4205282937 hasAuthorship W4205282937A5037677450 @default.
- W4205282937 hasAuthorship W4205282937A5052361307 @default.
- W4205282937 hasAuthorship W4205282937A5078039628 @default.
- W4205282937 hasBestOaLocation W42052829372 @default.
- W4205282937 hasConcept C113196181 @default.
- W4205282937 hasConcept C119128265 @default.
- W4205282937 hasConcept C137535248 @default.
- W4205282937 hasConcept C138850012 @default.
- W4205282937 hasConcept C145148216 @default.
- W4205282937 hasConcept C150394285 @default.
- W4205282937 hasConcept C153540111 @default.
- W4205282937 hasConcept C162356407 @default.
- W4205282937 hasConcept C162711632 @default.
- W4205282937 hasConcept C178790620 @default.
- W4205282937 hasConcept C185592680 @default.
- W4205282937 hasConcept C198291218 @default.