Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205288370> ?p ?o ?g. }
- W4205288370 abstract "MicroRNAs (miRNAs) are abundantly expressed in vasoactive intestinal peptide expressing (VIP+ ) interneurons and are indispensable for their functional maintenance and survival. Here, we blocked miRNA biogenesis in postmitotic VIP+ interneurons in mice by selectively ablating Dicer, an enzyme essential for miRNA maturation, to study whether ablation of VIP+ miRNA affects olfactory function and neural activity in olfactory centres such as the olfactory bulb, which contains a large number of VIP+ interneurons.A go/no-go odour discrimination task and a food-seeking test were used to assess olfactory discrimination and olfactory detection. In vivo electrophysiological techniques were used to record single units and local field potentials.Olfactory detection and olfactory discrimination behaviours were impaired in VIP+ -specific Dicer-knockout mice. In vivo electrophysiological recordings in awake, head-fixed mice showed that both spontaneous and odour-evoked firing rates were decreased in mitral/tufted cells in knockout mice. The power of ongoing and odour-evoked beta local field potentials response of the olfactory bulb and anterior piriform cortex were dramatically decreased. Furthermore, the coherence of theta oscillations between the olfactory bulb and anterior piriform cortex was decreased. Importantly, Dicer knockout restricted to olfactory bulb VIP+ interneurons recapitulated the behavioural and electrophysiological results of the global knockout.VIP+ miRNAs are an important factor in sensory processing, affecting olfactory function and olfactory neural activity." @default.
- W4205288370 created "2022-01-26" @default.
- W4205288370 creator A5027129012 @default.
- W4205288370 creator A5032831168 @default.
- W4205288370 creator A5056837078 @default.
- W4205288370 creator A5069756134 @default.
- W4205288370 creator A5078442277 @default.
- W4205288370 creator A5081761103 @default.
- W4205288370 creator A5085762574 @default.
- W4205288370 creator A5089603367 @default.
- W4205288370 creator A5091868989 @default.
- W4205288370 date "2022-01-12" @default.
- W4205288370 modified "2023-10-15" @default.
- W4205288370 title "Ablation of microRNAs in VIP <sup>+</sup> interneurons impairs olfactory discrimination and decreases neural activity in the olfactory bulb" @default.
- W4205288370 cites W144423133 @default.
- W4205288370 cites W1921182138 @default.
- W4205288370 cites W1945167963 @default.
- W4205288370 cites W1966943727 @default.
- W4205288370 cites W1970719523 @default.
- W4205288370 cites W1973275441 @default.
- W4205288370 cites W1974595624 @default.
- W4205288370 cites W1975437957 @default.
- W4205288370 cites W1983485262 @default.
- W4205288370 cites W1988411375 @default.
- W4205288370 cites W1991130313 @default.
- W4205288370 cites W1992910467 @default.
- W4205288370 cites W1993122722 @default.
- W4205288370 cites W1994565921 @default.
- W4205288370 cites W1996874802 @default.
- W4205288370 cites W1998274485 @default.
- W4205288370 cites W2000816595 @default.
- W4205288370 cites W2008027377 @default.
- W4205288370 cites W2010918615 @default.
- W4205288370 cites W2015205234 @default.
- W4205288370 cites W2015858554 @default.
- W4205288370 cites W2018683008 @default.
- W4205288370 cites W2019028138 @default.
- W4205288370 cites W2025603247 @default.
- W4205288370 cites W2027522454 @default.
- W4205288370 cites W2040574649 @default.
- W4205288370 cites W2041304216 @default.
- W4205288370 cites W2042662796 @default.
- W4205288370 cites W2056826598 @default.
- W4205288370 cites W2062875030 @default.
- W4205288370 cites W2065677411 @default.
- W4205288370 cites W2082397476 @default.
- W4205288370 cites W2085268149 @default.
- W4205288370 cites W2086535718 @default.
- W4205288370 cites W2089823661 @default.
- W4205288370 cites W2090724104 @default.
- W4205288370 cites W2092762034 @default.
- W4205288370 cites W2097237250 @default.
- W4205288370 cites W2104135721 @default.
- W4205288370 cites W2105336002 @default.
- W4205288370 cites W2114097748 @default.
- W4205288370 cites W2115491237 @default.
- W4205288370 cites W2117391818 @default.
- W4205288370 cites W2124520524 @default.
- W4205288370 cites W2131293603 @default.
- W4205288370 cites W2134455573 @default.
- W4205288370 cites W2144903600 @default.
- W4205288370 cites W2145160583 @default.
- W4205288370 cites W2150292683 @default.
- W4205288370 cites W2154041855 @default.
- W4205288370 cites W2160911021 @default.
- W4205288370 cites W2169302843 @default.
- W4205288370 cites W2179178098 @default.
- W4205288370 cites W2228967078 @default.
- W4205288370 cites W2295291491 @default.
- W4205288370 cites W2304994747 @default.
- W4205288370 cites W2306521117 @default.
- W4205288370 cites W2355573632 @default.
- W4205288370 cites W2491311433 @default.
- W4205288370 cites W2503929286 @default.
- W4205288370 cites W2515547613 @default.
- W4205288370 cites W2524300278 @default.
- W4205288370 cites W2578524981 @default.
- W4205288370 cites W2580178003 @default.
- W4205288370 cites W2589865885 @default.
- W4205288370 cites W2604871800 @default.
- W4205288370 cites W2605129411 @default.
- W4205288370 cites W2607724497 @default.
- W4205288370 cites W2663084651 @default.
- W4205288370 cites W2736432550 @default.
- W4205288370 cites W2749511316 @default.
- W4205288370 cites W2761818916 @default.
- W4205288370 cites W2769077758 @default.
- W4205288370 cites W2784951640 @default.
- W4205288370 cites W2790842764 @default.
- W4205288370 cites W2809362722 @default.
- W4205288370 cites W2910732406 @default.
- W4205288370 cites W2946491335 @default.
- W4205288370 cites W2946946072 @default.
- W4205288370 cites W2953237656 @default.
- W4205288370 cites W2982591362 @default.
- W4205288370 cites W2983248876 @default.
- W4205288370 cites W2990812548 @default.
- W4205288370 cites W3003972603 @default.
- W4205288370 cites W3004289368 @default.
- W4205288370 cites W3016652529 @default.