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- W4205296339 abstract "Condyloma acuminatum (CA) is a pathology caused by the human papillomavirus (HPV). It is manifested by the appearance of warts in the vulvar, pubic, and anorectal regions, but can occur in other areas. It is a common disease that can be prevented by using measures such as condoms or vaccine. Topical, local, pharmacological, surgical, and excisional therapy options are available for this pathology. Macroscopically, it appears as a vegetative tumor, with a single implantation base that branches towards the periphery, with a cauliflower appearance. CA is defined microscopically by acanthosis, parakeratosis, papillomatosis and koilocytosis. Immunohistochemical studies can detect the presence of various HPV strains or viral antigens and can emphasize certain specific characteristics; e.g., in the case presented in this study, we observed that the tumor had a fulminant evolution due to a strong vascular base identified with anti-cluster of differentiation (CD) 34 antibody, by the existence of epithelial cells with a high degree of cell proliferation, as evidenced by the anti-Ki67 antibody, the inactivation of the tumor suppressor gene and the appearance of immunolabeling for the anti-p53 antibody, by the strong immunoreactivity for p63 which reveals the existence of cells with dysplastic and neoplastic transformation potential, but also by detecting the immunolabeling for p16INK4a that is associated with the existence of HPV. Also, the tumor was immunoreactive for cytokeratin (CK) AE1∕AE3, partially immunoreactive for CK5∕6 in the basal layer and negative for CK7, which demonstrates the squamous epithelial origin of the described tumor. Subepithelial cells of the inflammatory system have been identified, such as macrophages immunolabeled with anti-CD68 antibody, T-lymphocytes immunolabeled with anti-CD3 antibody and rare B-lymphocytes immunolabeled with anti-CD20 antibody, which demonstrates the strong cellular response to remove the virus from the structure. Surgical and excisional treatment was helpful for the patient, because she was able to resume normal sexual activity and defecation, and on the other hand, microscopic studies showed the potential for malignant transformation of CA." @default.
- W4205296339 created "2022-01-25" @default.
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- W4205296339 date "2022-01-12" @default.
- W4205296339 modified "2023-10-18" @default.
- W4205296339 title "Clinical and pathological aspects of condyloma acuminatum – review of literature and case presentation" @default.
- W4205296339 cites W1484269883 @default.
- W4205296339 cites W1521262132 @default.
- W4205296339 cites W1544032942 @default.
- W4205296339 cites W156003141 @default.
- W4205296339 cites W1586414137 @default.
- W4205296339 cites W1596913774 @default.
- W4205296339 cites W1604503325 @default.
- W4205296339 cites W16310446 @default.
- W4205296339 cites W1637043931 @default.
- W4205296339 cites W172638913 @default.
- W4205296339 cites W1765473096 @default.
- W4205296339 cites W177017803 @default.
- W4205296339 cites W1814405991 @default.
- W4205296339 cites W181987742 @default.
- W4205296339 cites W1880227053 @default.
- W4205296339 cites W1907033805 @default.
- W4205296339 cites W1928599069 @default.
- W4205296339 cites W1935828301 @default.
- W4205296339 cites W1958258106 @default.
- W4205296339 cites W1963956401 @default.
- W4205296339 cites W1964918329 @default.
- W4205296339 cites W1965938169 @default.
- W4205296339 cites W1974208182 @default.
- W4205296339 cites W1980724085 @default.
- W4205296339 cites W1983187600 @default.
- W4205296339 cites W1988810258 @default.
- W4205296339 cites W1990259698 @default.
- W4205296339 cites W1990639420 @default.
- W4205296339 cites W1995856480 @default.
- W4205296339 cites W1996319104 @default.
- W4205296339 cites W1997073961 @default.
- W4205296339 cites W199777777 @default.
- W4205296339 cites W1999869926 @default.
- W4205296339 cites W2000357107 @default.
- W4205296339 cites W2001108463 @default.
- W4205296339 cites W2002173924 @default.
- W4205296339 cites W2005374729 @default.
- W4205296339 cites W2007974053 @default.
- W4205296339 cites W2009817267 @default.
- W4205296339 cites W2011495713 @default.
- W4205296339 cites W2011727075 @default.
- W4205296339 cites W2012514476 @default.
- W4205296339 cites W2014938226 @default.
- W4205296339 cites W2016897735 @default.
- W4205296339 cites W2021479709 @default.
- W4205296339 cites W2025671366 @default.
- W4205296339 cites W2027959940 @default.
- W4205296339 cites W2029936300 @default.
- W4205296339 cites W2035849601 @default.
- W4205296339 cites W2039382131 @default.
- W4205296339 cites W2045415100 @default.
- W4205296339 cites W2049641944 @default.
- W4205296339 cites W2049851955 @default.
- W4205296339 cites W2054222404 @default.
- W4205296339 cites W2055138094 @default.
- W4205296339 cites W2057366746 @default.
- W4205296339 cites W2058144993 @default.
- W4205296339 cites W2058786984 @default.
- W4205296339 cites W2070854644 @default.
- W4205296339 cites W2076808904 @default.
- W4205296339 cites W2078221536 @default.
- W4205296339 cites W2083796093 @default.
- W4205296339 cites W2085234632 @default.
- W4205296339 cites W2091040370 @default.
- W4205296339 cites W2091040995 @default.
- W4205296339 cites W2094915859 @default.
- W4205296339 cites W2097544305 @default.
- W4205296339 cites W2101933488 @default.
- W4205296339 cites W2102786052 @default.
- W4205296339 cites W2104495908 @default.
- W4205296339 cites W2112271815 @default.
- W4205296339 cites W2126859740 @default.
- W4205296339 cites W2127475069 @default.
- W4205296339 cites W2130121301 @default.
- W4205296339 cites W2132337002 @default.
- W4205296339 cites W2133763592 @default.
- W4205296339 cites W2134364546 @default.
- W4205296339 cites W2136171269 @default.
- W4205296339 cites W2136212529 @default.
- W4205296339 cites W2137231932 @default.
- W4205296339 cites W2138584423 @default.
- W4205296339 cites W2141809669 @default.
- W4205296339 cites W2142280079 @default.
- W4205296339 cites W2151115815 @default.