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- W4205301876 abstract "Background: Schiff bases play key role for the generation of a large number of biologically active compounds via cycloaddition, replacement and ring closure reactions. Objective: The objective of this study is to optimize the purity and yield of product, reaction time, eco-friendly reaction by the help of microwave assisted organic synthesis. Methods: New series of Schiff’s bases of triazole derivatives were achieved via multicomponent reactions. The starting material benzohydrazide 1 was obtained by esterification of bezoyl chloride with methanol in presence of concentrated sulphuric acid followed by the reaction with hydrazine hydrate. Benzohydrazide was allowed to react with carbon disulphide in ethanolic potassium hydroxide solution to yield potassium dithiocarbazinate 2 which undergoes cyclization by reacting with hydrazine hydrate to afford 4-[amino]-5-phenyl-4H-1,2,4-triazole-3-thiol (3). Further, various Schiff’s bases 4a-f were obtained by reacting 1,2,4-triazole-3-thiol with different substituted benzaldehydes under microwave irradiations as a green and eco-friendly energy source. Results: The structures of the newly synthesized compounds were elucidated in accordance with their spectral data and elemental analysis. Conclusion : The obtained compounds exhibited significant in-vivo anti-diabetic activity as compared to the standard drug Metformin. The anti-diabetic effect was investigated by using Alloxan-induced diabetic model." @default.
- W4205301876 created "2022-01-25" @default.
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- W4205301876 date "2021-09-30" @default.
- W4205301876 modified "2023-09-27" @default.
- W4205301876 title "Synthesis of Schiff’s Bases of 1,2,4-Triazole Derivatives under Microwave Irradiation Technique and Evaluation of Their Anti-diabetic Activity" @default.
- W4205301876 doi "https://doi.org/10.2174/2213335608666210930201144" @default.
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