Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205320426> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4205320426 abstract "<p>Because dysfunctions of endothelial cells are involved in many pathologies, <i>in vitro </i>endothelial cell models for pathophysiological and pharmaceutical studies have been a valuable research tool. Although numerous microfluidic-based endothelial models have been reported, they had the cells cultured on a flat surface without considering the possible 3D structure of the native ECM. Endothelial cells rest on the basement membrane <i>in vivo</i>, which contains an aligned microfibrous topography. To better understand and model the cells, it is necessary to know if and how the fibrous topography can affect endothelial functions. With conventional fully integrated microfluidic apparatus, it is difficult to include additional topographies in a microchannel. Therefore, we developed a modular microfluidic system by 3D-printing and electrospinning, which enabled easy integration and switching of desired ECM topographies. Also, with standardized designs, the system allowed for high flow rates up to 4000 µL/min, which covered the full shear stress range for endothelial studies. We found that the aligned fibrous topography on the ECM altered arginine metabolism in endothelial cells, and thus increased nitric oxide production. To the best of our knowledge, this is the most versatile endothelial model that has been reported, and the new knowledge generated thereby lays a groundwork for future endothelial research and modeling. </p>" @default.
- W4205320426 created "2022-01-25" @default.
- W4205320426 creator A5011528604 @default.
- W4205320426 creator A5029848713 @default.
- W4205320426 creator A5033613250 @default.
- W4205320426 creator A5046613353 @default.
- W4205320426 date "2020-09-24" @default.
- W4205320426 modified "2023-10-16" @default.
- W4205320426 title "A 3D-Printed, Modular, and Parallelized Microfluidic System with Customizable ECM Integration to Investigate the Roles of Basement Membrane Topography on Endothelial Cells" @default.
- W4205320426 doi "https://doi.org/10.26434/chemrxiv.12995846" @default.
- W4205320426 hasPublicationYear "2020" @default.
- W4205320426 type Work @default.
- W4205320426 citedByCount "0" @default.
- W4205320426 crossrefType "posted-content" @default.
- W4205320426 hasAuthorship W4205320426A5011528604 @default.
- W4205320426 hasAuthorship W4205320426A5029848713 @default.
- W4205320426 hasAuthorship W4205320426A5033613250 @default.
- W4205320426 hasAuthorship W4205320426A5046613353 @default.
- W4205320426 hasBestOaLocation W42053204261 @default.
- W4205320426 hasConcept C101468663 @default.
- W4205320426 hasConcept C111919701 @default.
- W4205320426 hasConcept C123012128 @default.
- W4205320426 hasConcept C127413603 @default.
- W4205320426 hasConcept C136229726 @default.
- W4205320426 hasConcept C150903083 @default.
- W4205320426 hasConcept C171250308 @default.
- W4205320426 hasConcept C185592680 @default.
- W4205320426 hasConcept C192562407 @default.
- W4205320426 hasConcept C202751555 @default.
- W4205320426 hasConcept C207001950 @default.
- W4205320426 hasConcept C2776193487 @default.
- W4205320426 hasConcept C41008148 @default.
- W4205320426 hasConcept C55493867 @default.
- W4205320426 hasConcept C8673954 @default.
- W4205320426 hasConcept C86803240 @default.
- W4205320426 hasConcept C95444343 @default.
- W4205320426 hasConceptScore W4205320426C101468663 @default.
- W4205320426 hasConceptScore W4205320426C111919701 @default.
- W4205320426 hasConceptScore W4205320426C123012128 @default.
- W4205320426 hasConceptScore W4205320426C127413603 @default.
- W4205320426 hasConceptScore W4205320426C136229726 @default.
- W4205320426 hasConceptScore W4205320426C150903083 @default.
- W4205320426 hasConceptScore W4205320426C171250308 @default.
- W4205320426 hasConceptScore W4205320426C185592680 @default.
- W4205320426 hasConceptScore W4205320426C192562407 @default.
- W4205320426 hasConceptScore W4205320426C202751555 @default.
- W4205320426 hasConceptScore W4205320426C207001950 @default.
- W4205320426 hasConceptScore W4205320426C2776193487 @default.
- W4205320426 hasConceptScore W4205320426C41008148 @default.
- W4205320426 hasConceptScore W4205320426C55493867 @default.
- W4205320426 hasConceptScore W4205320426C8673954 @default.
- W4205320426 hasConceptScore W4205320426C86803240 @default.
- W4205320426 hasConceptScore W4205320426C95444343 @default.
- W4205320426 hasLocation W42053204261 @default.
- W4205320426 hasLocation W42053204262 @default.
- W4205320426 hasOpenAccess W4205320426 @default.
- W4205320426 hasPrimaryLocation W42053204261 @default.
- W4205320426 hasRelatedWork W14333721 @default.
- W4205320426 hasRelatedWork W18652115 @default.
- W4205320426 hasRelatedWork W20064308 @default.
- W4205320426 hasRelatedWork W20263476 @default.
- W4205320426 hasRelatedWork W2092559 @default.
- W4205320426 hasRelatedWork W22857379 @default.
- W4205320426 hasRelatedWork W4215431 @default.
- W4205320426 hasRelatedWork W5410578 @default.
- W4205320426 hasRelatedWork W725095 @default.
- W4205320426 hasRelatedWork W22450398 @default.
- W4205320426 isParatext "false" @default.
- W4205320426 isRetracted "false" @default.
- W4205320426 workType "article" @default.