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- W4205331756 endingPage "1255" @default.
- W4205331756 startingPage "1235" @default.
- W4205331756 abstract "Cellular senescence within the cardiovascular system has, until recently, been understudied and unappreciated as a factor in the development of age‐related cardiovascular diseases such as heart failure, myocardial infarction and atherosclerosis. This is in part due to challenges with defining senescence within post‐mitotic cells such as cardiomyocytes. However, recent evidence has demonstrated senescent‐like changes, including a senescence‐associated secretory phenotype (SASP), in cardiomyocytes in response to ageing and cell stress. Other replicating cells, including fibroblasts and vascular smooth muscle cells, within the cardiovascular system have also been shown to undergo senescence and contribute to disease pathogenesis. These findings coupled with the emergence of senolytic therapies, to target and eliminate senescent cells, have provided fascinating new avenues for management of several age‐related cardiovascular diseases with high prevalence. In this review, we discuss the role of senescent cells within the cardiovascular system and highlight the contribution of senescence cells to common cardiovascular diseases. We discuss the emerging role for senolytics in cardiovascular disease management while highlighting important aspects of senescence biology which must be clarified before the potential of senolytics can be fully realized." @default.
- W4205331756 created "2022-01-26" @default.
- W4205331756 creator A5000353690 @default.
- W4205331756 creator A5021099644 @default.
- W4205331756 creator A5071216592 @default.
- W4205331756 date "2022-01-25" @default.
- W4205331756 modified "2023-10-17" @default.
- W4205331756 title "Therapeutic opportunities for senolysis in cardiovascular disease" @default.
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