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• W4205334013 abstract "During a screening for antifungal secondary metabolites, six new mono-/bis-alkenoic acid derivatives ( 2 – 7 ) and one known alkenoic acid derivative ( 1 ) were isolated from an endophytic fungi Scopulariopsis candelabrum . Their chemical structures were identified by 1 H-NMR, 13 C-NMR, 2D NMR, and high-resolution mass spectrometry, as well as comparisons with previously reported literatures. Among them, fusariumesters C‒F ( 2 – 5 ) are bis-alkenoic acid derivatives dimerized by an ester bond, while acetylfusaridioic acid A ( 6 ) and fusaridioic acid D ( 7 ) are alkenoic acid monomers. All the isolates were submitted to an antifungal assay against Candida albicans and the corn pathogen Exserohilum turcicum using the filter paper agar diffusion method. As a result, only compound 1 decorating with β -lactone ring turned out to be active against these two tested fungi. The broth microdilution assay against Candida albicans showed the minimum inhibitory concentration (MIC) value of 1 to be 20 μ g/ml, while the minimum inhibitory concentration value of the positive control (naystatin) was 10 μ g/ml. And the half maximal inhibitory concentration (IC 50 ) value (21.23 μ g/ml) of 1 against Exserohilum turcicum was determined by analyzing its inhibition effect on the mycelial growth, using cycloheximide (IC 50 = 46.70 μ g/ml) as the positive control." @default.
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• W4205334013 date "2022-01-11" @default.
• W4205334013 modified "2023-09-28" @default.
• W4205334013 title "Mono-/Bis-Alkenoic Acid Derivatives From an Endophytic Fungus Scopulariopsis candelabrum and Their Antifungal Activity" @default.
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• W4205334013 doi "https://doi.org/10.3389/fchem.2021.812564" @default.
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