FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205334095> ?p ?o ?g. }

• W4205334095 endingPage "174750" @default.
• W4205334095 startingPage "174750" @default.
• W4205334095 abstract "The mechanisms by which a high-fat diet (HFD) promotes non-alcoholic fatty liver disease (NAFLD) appear to involve liver mitochondrial dysfunction and redox imbalance. The functional loss of the enzyme NAD(P)+ transhydrogenase, a main source of mitochondrial NADPH, results in impaired mitochondrial peroxide removal, pyruvate dehydrogenase inhibition by phosphorylation, and progression of NAFLD in HFD-fed mice. The present study aimed to investigate whether pharmacological reactivation of pyruvate dehydrogenase by dichloroacetate attenuates the mitochondrial redox dysfunction and the development of NAFLD in NAD(P)+ transhydrogenase-null (Nnt-/-) mice fed an HFD (60% of total calories from fat). For this purpose, Nnt-/- mice and their congenic controls (Nnt+/+) were fed chow or an HFD for 20 weeks and received sodium dichloroacetate or NaCl in the final 12 weeks via drinking water. The results showed that HFD reduced the ability of isolated liver mitochondria from Nnt-/- mice to remove peroxide, which was prevented by the dichloroacetate treatment. HFD-fed mice of both Nnt genotypes exhibited increased body and liver mass, as well as a higher content of hepatic triglycerides, but dichloroacetate treatment attenuated these abnormalities only in Nnt-/- mice. Notably, dichloroacetate treatment decreased liver pyruvate dehydrogenase phosphorylation levels and prevented the aggravation of NAFLD in HFD-fed Nnt-/- mice. Conversely, dichloroacetate treatment elicited moderate hepatocyte ballooning in chow-fed mice, suggesting potentially toxic effects. We conclude that the protection against HFD-induced NAFLD by dichloroacetate is associated with its role in reactivating pyruvate dehydrogenase and reestablishing the pyruvate-supported liver mitochondrial capacity to handle peroxide in Nnt-/- mice." @default.
• W4205334095 created "2022-01-26" @default.
• W4205334095 creator A5001459772 @default.
• W4205334095 creator A5009436062 @default.
• W4205334095 creator A5009718156 @default.
• W4205334095 creator A5057698006 @default.
• W4205334095 creator A5057989875 @default.
• W4205334095 creator A5060197666 @default.
• W4205334095 creator A5064753559 @default.
• W4205334095 date "2022-02-01" @default.
• W4205334095 modified "2023-10-16" @default.
• W4205334095 title "Dichloroacetate reactivates pyruvate-supported peroxide removal by liver mitochondria and prevents NAFLD aggravation in NAD(P)+ transhydrogenase-null mice consuming a high-fat diet" @default.
• W4205334095 cites W1963683487 @default.
• W4205334095 cites W1967821711 @default.
• W4205334095 cites W1977194186 @default.
• W4205334095 cites W1982223753 @default.
• W4205334095 cites W1983824186 @default.
• W4205334095 cites W1997037720 @default.
• W4205334095 cites W1999719799 @default.
• W4205334095 cites W2000697370 @default.
• W4205334095 cites W2003578107 @default.
• W4205334095 cites W2008697716 @default.
• W4205334095 cites W2015019014 @default.
• W4205334095 cites W2035797613 @default.
• W4205334095 cites W2038992526 @default.
• W4205334095 cites W2067740038 @default.
• W4205334095 cites W2081650862 @default.
• W4205334095 cites W2092568560 @default.
• W4205334095 cites W2098317565 @default.
• W4205334095 cites W2106532277 @default.
• W4205334095 cites W2116337347 @default.
• W4205334095 cites W2120343721 @default.
• W4205334095 cites W2120958765 @default.
• W4205334095 cites W2131395656 @default.
• W4205334095 cites W2345848068 @default.
• W4205334095 cites W2467847304 @default.
• W4205334095 cites W2481948442 @default.
• W4205334095 cites W2487313069 @default.
• W4205334095 cites W2503267861 @default.
• W4205334095 cites W2511630563 @default.
• W4205334095 cites W2535392697 @default.
• W4205334095 cites W2753970165 @default.
• W4205334095 cites W2757468697 @default.
• W4205334095 cites W2767674938 @default.
• W4205334095 cites W2795085390 @default.
• W4205334095 cites W2800258246 @default.
• W4205334095 cites W2889048706 @default.
• W4205334095 cites W2894984077 @default.
• W4205334095 cites W2951752428 @default.
• W4205334095 cites W2970720037 @default.
• W4205334095 cites W3039547617 @default.
• W4205334095 cites W3115091968 @default.
• W4205334095 cites W3118637683 @default.
• W4205334095 cites W3131347812 @default.
• W4205334095 cites W3134444438 @default.
• W4205334095 cites W3176576117 @default.
• W4205334095 cites W3183390415 @default.
• W4205334095 cites W4231256899 @default.
• W4205334095 doi "https://doi.org/10.1016/j.ejphar.2022.174750" @default.
• W4205334095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35032488" @default.
• W4205334095 hasPublicationYear "2022" @default.
• W4205334095 type Work @default.
• W4205334095 citedByCount "2" @default.
• W4205334095 countsByYear W42053340952022 @default.
• W4205334095 countsByYear W42053340952023 @default.
• W4205334095 crossrefType "journal-article" @default.
• W4205334095 hasAuthorship W4205334095A5001459772 @default.
• W4205334095 hasAuthorship W4205334095A5009436062 @default.
• W4205334095 hasAuthorship W4205334095A5009718156 @default.
• W4205334095 hasAuthorship W4205334095A5057698006 @default.
• W4205334095 hasAuthorship W4205334095A5057989875 @default.
• W4205334095 hasAuthorship W4205334095A5060197666 @default.
• W4205334095 hasAuthorship W4205334095A5064753559 @default.
• W4205334095 hasConcept C101972281 @default.
• W4205334095 hasConcept C126322002 @default.
• W4205334095 hasConcept C134018914 @default.
• W4205334095 hasConcept C181199279 @default.
• W4205334095 hasConcept C185592680 @default.
• W4205334095 hasConcept C2778772119 @default.
• W4205334095 hasConcept C2779134260 @default.
• W4205334095 hasConcept C28859421 @default.
• W4205334095 hasConcept C55493867 @default.
• W4205334095 hasConcept C71924100 @default.
• W4205334095 hasConcept C75520062 @default.
• W4205334095 hasConcept C86803240 @default.
• W4205334095 hasConcept C88099638 @default.
• W4205334095 hasConcept C9506865 @default.
• W4205334095 hasConceptScore W4205334095C101972281 @default.
• W4205334095 hasConceptScore W4205334095C126322002 @default.
• W4205334095 hasConceptScore W4205334095C134018914 @default.
• W4205334095 hasConceptScore W4205334095C181199279 @default.
• W4205334095 hasConceptScore W4205334095C185592680 @default.
• W4205334095 hasConceptScore W4205334095C2778772119 @default.
• W4205334095 hasConceptScore W4205334095C2779134260 @default.
• W4205334095 hasConceptScore W4205334095C28859421 @default.
• W4205334095 hasConceptScore W4205334095C55493867 @default.
• W4205334095 hasConceptScore W4205334095C71924100 @default.
• W4205334095 hasConceptScore W4205334095C75520062 @default.

• next