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• W4205345269 endingPage "148" @default.
• W4205345269 startingPage "148" @default.
• W4205345269 abstract "Mucosal-Associated Invariant T (MAIT) cells have been shown to play protective roles during infection with diverse pathogens through their propensity for rapid innate-like cytokine production and cytotoxicity. Among the potential applications for MAIT cells is to defend against Staphylococcus aureus, a pathogen of serious clinical significance. However, it is unknown how MAIT cell responses to S. aureus are elicited, nor has it been investigated whether MAIT cell cytotoxicity is mobilized against intracellular S. aureus. In this study, we investigate the capacity of human MAIT cells to respond directly to S. aureus. MAIT cells co-cultured with dendritic cells (DCs) infected with S. aureus rapidly upregulate CD69, express IFNγ and Granzyme B and degranulate. DC secretion of IL-12, but not IL-18, was implicated in this immune response, while TCR binding of MR1 is required to commence cytokine production. MAIT cell cytotoxicity resulted in apoptosis of S. aureus-infected cells, and reduced intracellular persistence of S. aureus. These findings implicate these unconventional T cells in important, rapid anti-S. aureus responses that may be of great relevance to the ongoing development of novel anti-S. aureus treatments." @default.
• W4205345269 created "2022-01-25" @default.
• W4205345269 creator A5013686383 @default.
• W4205345269 creator A5014499922 @default.
• W4205345269 creator A5040729820 @default.
• W4205345269 creator A5067748719 @default.
• W4205345269 creator A5085310352 @default.
• W4205345269 date "2022-01-12" @default.
• W4205345269 modified "2023-10-14" @default.
• W4205345269 title "Human MAIT Cells Respond to Staphylococcus aureus with Enhanced Anti-Bacterial Activity" @default.
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