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- W4205348135 endingPage "840" @default.
- W4205348135 startingPage "840" @default.
- W4205348135 abstract "Group I metabotropic glutamate (mGlu) receptors (mGlu1/5 subtypes) are G protein-coupled receptors and are broadly expressed in the mammalian brain. These receptors play key roles in the modulation of normal glutamatergic transmission and synaptic plasticity, and abnormal mGlu1/5 signaling is linked to the pathogenesis and symptomatology of various mental and neurological disorders. Group I mGlu receptors are noticeably regulated via a mechanism involving dynamic protein-protein interactions. Several synaptic protein kinases were recently found to directly bind to the intracellular domains of mGlu1/5 receptors and phosphorylate the receptors at distinct amino acid residues. A variety of scaffolding and adaptor proteins also interact with mGlu1/5. Constitutive or activity-dependent interactions between mGlu1/5 and their interacting partners modulate trafficking, anchoring, and expression of the receptors. The mGlu1/5-associated proteins also finetune the efficacy of mGlu1/5 postreceptor signaling and mGlu1/5-mediated synaptic plasticity. This review analyzes the data from recent studies and provides an update on the biochemical and physiological properties of a set of proteins or molecules that interact with and thus regulate mGlu1/5 receptors." @default.
- W4205348135 created "2022-01-25" @default.
- W4205348135 creator A5015897926 @default.
- W4205348135 creator A5049821571 @default.
- W4205348135 creator A5081841685 @default.
- W4205348135 creator A5084182199 @default.
- W4205348135 date "2022-01-13" @default.
- W4205348135 modified "2023-09-26" @default.
- W4205348135 title "Group I Metabotropic Glutamate Receptors and Interacting Partners: An Update" @default.
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- W4205348135 doi "https://doi.org/10.3390/ijms23020840" @default.
- W4205348135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35055030" @default.