FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205350403> ?p ?o ?g. }

• W4205350403 abstract "As a putative model of Fasciola gigantica infection, detailed data in Kunming (KM) mice infected with F. gigantica are lacking. In this study, KM mice were orally infected with 15 metacercaria for 8 weeks. Macroscopic and microscopic changes, serum biochemistry, cytokine responses, and changes in parasite-specific immunoglobulin G (IgG) antibody levels were monitored at 1, 3, 5, 7, and 8 weeks post-infection (wpi), respectively. The serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) increased after infection, while that of albumin (ALB) decreased, which was positively correlated with the degree of liver damage. Between 5 and 7 wpi, the mice showed symptoms of anemia and weight loss, possibly caused by the decrease of alkaline phosphatase (ALP). Moreover, the changing tendencies of the levels of globulin (GLB) and parasite-specific IgG antibody were similar, suggesting a potential correlation between GLB production and adaptive immune response in the host. Coordinated variations in interferon gamma (IFN-γ) and interleukin 4 (IL-4) indicated a mixed T helper 1 (Th1)/Th2 cellular immune response. Furthermore, the serum IgG antibody increased after infection and peaked at 5 wpi, and it was positively correlated with the average parasite burdens. The worms collected from mice were approximately 1 cm in length at 8 wpi, their digestive and reproductive systems were well developed, and no eggs were found in the uterus. To the best of our knowledge, this is the first report describing detailed histological, biochemical, and immunological indices in KM mice infected with F. gigantica, which provides basic information on KM mice against infection with F. gigantica." @default.
• W4205350403 created "2022-01-25" @default.
• W4205350403 creator A5013641001 @default.
• W4205350403 creator A5030839338 @default.
• W4205350403 creator A5038103099 @default.
• W4205350403 creator A5045423783 @default.
• W4205350403 creator A5069714012 @default.
• W4205350403 creator A5073274884 @default.
• W4205350403 date "2022-01-05" @default.
• W4205350403 modified "2023-09-25" @default.
• W4205350403 title "Characterization of the Pathology, Biochemistry, and Immune Response in Kunming (KM) Mice Following Fasciola gigantica Infection" @default.
• W4205350403 cites W1967850098 @default.
• W4205350403 cites W1969618160 @default.
• W4205350403 cites W1971415551 @default.
• W4205350403 cites W1973366562 @default.
• W4205350403 cites W1978567215 @default.
• W4205350403 cites W1978799431 @default.
• W4205350403 cites W1980571225 @default.
• W4205350403 cites W1981058244 @default.
• W4205350403 cites W1986256365 @default.
• W4205350403 cites W1987646859 @default.
• W4205350403 cites W1991040673 @default.
• W4205350403 cites W1994092104 @default.
• W4205350403 cites W1995588860 @default.
• W4205350403 cites W1998457105 @default.
• W4205350403 cites W2001233384 @default.
• W4205350403 cites W2011374843 @default.
• W4205350403 cites W2018611922 @default.
• W4205350403 cites W2032430643 @default.
• W4205350403 cites W2035186028 @default.
• W4205350403 cites W2039704160 @default.
• W4205350403 cites W2042934882 @default.
• W4205350403 cites W2047189370 @default.
• W4205350403 cites W2054203673 @default.
• W4205350403 cites W2059469821 @default.
• W4205350403 cites W2060205727 @default.
• W4205350403 cites W2062027168 @default.
• W4205350403 cites W2069500720 @default.
• W4205350403 cites W2075774005 @default.
• W4205350403 cites W2078162613 @default.
• W4205350403 cites W2079246556 @default.
• W4205350403 cites W2080513175 @default.
• W4205350403 cites W2086958034 @default.
• W4205350403 cites W2087001215 @default.
• W4205350403 cites W2092756966 @default.
• W4205350403 cites W2095287591 @default.
• W4205350403 cites W2096782381 @default.
• W4205350403 cites W2100299118 @default.
• W4205350403 cites W2104790952 @default.
• W4205350403 cites W2109554224 @default.
• W4205350403 cites W2111408714 @default.
• W4205350403 cites W2120358180 @default.
• W4205350403 cites W2132727601 @default.
• W4205350403 cites W2145868389 @default.
• W4205350403 cites W2146059948 @default.
• W4205350403 cites W2163381524 @default.
• W4205350403 cites W2280046886 @default.
• W4205350403 cites W2312396647 @default.
• W4205350403 cites W2315372070 @default.
• W4205350403 cites W2328616901 @default.
• W4205350403 cites W2329400159 @default.
• W4205350403 cites W2332318718 @default.
• W4205350403 cites W2338346032 @default.
• W4205350403 cites W2403132898 @default.
• W4205350403 cites W2435471208 @default.
• W4205350403 cites W2524755832 @default.
• W4205350403 cites W2612351849 @default.
• W4205350403 cites W2736460824 @default.
• W4205350403 cites W2753423724 @default.
• W4205350403 cites W2771090541 @default.
• W4205350403 cites W4229653719 @default.
• W4205350403 cites W4295008070 @default.
• W4205350403 cites W7854674 @default.
• W4205350403 cites W89347711 @default.
• W4205350403 doi "https://doi.org/10.3389/fcimb.2021.793571" @default.
• W4205350403 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35071045" @default.
• W4205350403 hasPublicationYear "2022" @default.
• W4205350403 type Work @default.
• W4205350403 citedByCount "3" @default.
• W4205350403 countsByYear W42053504032022 @default.
• W4205350403 countsByYear W42053504032023 @default.
• W4205350403 crossrefType "journal-article" @default.
• W4205350403 hasAuthorship W4205350403A5013641001 @default.
• W4205350403 hasAuthorship W4205350403A5030839338 @default.
• W4205350403 hasAuthorship W4205350403A5038103099 @default.
• W4205350403 hasAuthorship W4205350403A5045423783 @default.
• W4205350403 hasAuthorship W4205350403A5069714012 @default.
• W4205350403 hasAuthorship W4205350403A5073274884 @default.
• W4205350403 hasBestOaLocation W42053504031 @default.
• W4205350403 hasConcept C134018914 @default.
• W4205350403 hasConcept C136764020 @default.
• W4205350403 hasConcept C159654299 @default.
• W4205350403 hasConcept C160160445 @default.
• W4205350403 hasConcept C165901193 @default.
• W4205350403 hasConcept C181199279 @default.
• W4205350403 hasConcept C203014093 @default.
• W4205350403 hasConcept C2776125364 @default.
• W4205350403 hasConcept C2778690821 @default.
• W4205350403 hasConcept C2779487569 @default.
• W4205350403 hasConcept C41008148 @default.

• next