Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205395879> ?p ?o ?g. }
- W4205395879 endingPage "1097" @default.
- W4205395879 startingPage "1097" @default.
- W4205395879 abstract "Sepsis has recently been defined as life-threatening organ dysfunction caused by the dysregulated host response to an ongoing or suspected infection. To date, sepsis continues to be a leading cause of morbidity and mortality amongst hospitalized patients. Many risk factors contribute to development of sepsis, including pain-relieving drugs like opioids, which are frequently prescribed post-operatively. In light of the opioid crisis, understanding the interactions between opioid use and the development of sepsis has become extremely relevant, as opioid use is associated with increased risk of infection. Given that the intestinal tract is a major site of origin of sepsis-causing microbes, there has been an increasing focus on how alterations in the gut microbiome may predispose towards sepsis and mediate immune dysregulation. MicroRNAs, in particular, have emerged as key modulators of the inflammatory response during sepsis by tempering the immune response, thereby mediating the interaction between host and microbiome. In this review, we elucidate contributing roles of microRNA 146 in modulating sepsis pathogenesis and end with a discussion of therapeutic targeting of the gut microbiome in controlling immune dysregulation in sepsis." @default.
- W4205395879 created "2022-01-26" @default.
- W4205395879 creator A5048411184 @default.
- W4205395879 creator A5076582125 @default.
- W4205395879 creator A5077274375 @default.
- W4205395879 creator A5083533514 @default.
- W4205395879 date "2022-01-20" @default.
- W4205395879 modified "2023-10-13" @default.
- W4205395879 title "Opioids and Sepsis: Elucidating the Role of the Microbiome and microRNA-146" @default.
- W4205395879 cites W1912521894 @default.
- W4205395879 cites W1922587735 @default.
- W4205395879 cites W1961542776 @default.
- W4205395879 cites W1964968781 @default.
- W4205395879 cites W1967774301 @default.
- W4205395879 cites W1982222331 @default.
- W4205395879 cites W1986046869 @default.
- W4205395879 cites W1994197895 @default.
- W4205395879 cites W1999906527 @default.
- W4205395879 cites W2007176734 @default.
- W4205395879 cites W2012162544 @default.
- W4205395879 cites W2013196466 @default.
- W4205395879 cites W2015367177 @default.
- W4205395879 cites W2016213571 @default.
- W4205395879 cites W2016912297 @default.
- W4205395879 cites W2024357783 @default.
- W4205395879 cites W2028600696 @default.
- W4205395879 cites W2031600432 @default.
- W4205395879 cites W2032453778 @default.
- W4205395879 cites W2035772899 @default.
- W4205395879 cites W2045119680 @default.
- W4205395879 cites W2048502267 @default.
- W4205395879 cites W2049699367 @default.
- W4205395879 cites W2049927822 @default.
- W4205395879 cites W2051678830 @default.
- W4205395879 cites W2052554412 @default.
- W4205395879 cites W2055313665 @default.
- W4205395879 cites W2062757127 @default.
- W4205395879 cites W2070777085 @default.
- W4205395879 cites W2075860675 @default.
- W4205395879 cites W2076276989 @default.
- W4205395879 cites W2077553363 @default.
- W4205395879 cites W2077582952 @default.
- W4205395879 cites W2083513831 @default.
- W4205395879 cites W2094224794 @default.
- W4205395879 cites W2101619948 @default.
- W4205395879 cites W2109142739 @default.
- W4205395879 cites W2121725913 @default.
- W4205395879 cites W2131987394 @default.
- W4205395879 cites W2139284253 @default.
- W4205395879 cites W2145672285 @default.
- W4205395879 cites W2152310279 @default.
- W4205395879 cites W2163968592 @default.
- W4205395879 cites W2165158988 @default.
- W4205395879 cites W2165757656 @default.
- W4205395879 cites W2168535440 @default.
- W4205395879 cites W2171982502 @default.
- W4205395879 cites W2174358501 @default.
- W4205395879 cites W2181406139 @default.
- W4205395879 cites W2199095759 @default.
- W4205395879 cites W2216794415 @default.
- W4205395879 cites W2233291722 @default.
- W4205395879 cites W2269501814 @default.
- W4205395879 cites W2280404143 @default.
- W4205395879 cites W2289575399 @default.
- W4205395879 cites W2300040465 @default.
- W4205395879 cites W2342887013 @default.
- W4205395879 cites W2343186061 @default.
- W4205395879 cites W2396727790 @default.
- W4205395879 cites W2426464690 @default.
- W4205395879 cites W2496787786 @default.
- W4205395879 cites W2512462498 @default.
- W4205395879 cites W2531152324 @default.
- W4205395879 cites W2550242928 @default.
- W4205395879 cites W2571593691 @default.
- W4205395879 cites W2572058121 @default.
- W4205395879 cites W2587845606 @default.
- W4205395879 cites W2588681363 @default.
- W4205395879 cites W2593597645 @default.
- W4205395879 cites W2608823051 @default.
- W4205395879 cites W2613064135 @default.
- W4205395879 cites W2742395325 @default.
- W4205395879 cites W2749328728 @default.
- W4205395879 cites W2755626276 @default.
- W4205395879 cites W2755716296 @default.
- W4205395879 cites W2777682558 @default.
- W4205395879 cites W2781940944 @default.
- W4205395879 cites W2790723064 @default.
- W4205395879 cites W2791788772 @default.
- W4205395879 cites W2805365360 @default.
- W4205395879 cites W2810245133 @default.
- W4205395879 cites W2883316818 @default.
- W4205395879 cites W2888953943 @default.
- W4205395879 cites W2894865228 @default.
- W4205395879 cites W2901833490 @default.
- W4205395879 cites W2901973893 @default.
- W4205395879 cites W2911230342 @default.
- W4205395879 cites W2912654712 @default.
- W4205395879 cites W2921966151 @default.