Matches in SemOpenAlex for { <https://semopenalex.org/work/W4205396058> ?p ?o ?g. }
Showing items 1 to 53 of
53
with 100 items per page.
- W4205396058 abstract "Allergic asthma is an inflammatory lung disease initiated and directed by T helper cells type 2 (Th2). The mechanism involved in generation of Th2 responses to inert inhaled antigens, however, is unknown. Epidemiological evidence suggests that exposure to lipopolysaccharide (LPS) or other microbial products can influence the development and severity of asthma. However, the mechanism by which LPS influences asthma pathogenesis remains undefined. Although it is known that signaling through Toll-like receptors (TLR) is required for adaptive T helper cell type 1 (Th1) responses, it is unclear if TLRs are needed for Th2 priming. Here, we report that low level inhaled LPS signaling through TLR4 is necessary to induce Th2 responses to inhaled antigens in a mouse model of allergic sensitization. The mechanism by which LPS signaling results in Th2 sensitization involves the activation of antigen-containing dendritic cells. In contrast to low levels, inhalation of high levels of LPS with antigen results in Th1 responses. These studies suggest that the level of LPS exposure can determine the type of inflammatory response generated and provide a potential mechanistic explanation of epidemiological data on endotoxin exposure and asthma prevalence. PMID: 12486107 Funding information This work was supported by: NHLBI NIH HHS, United States Grant ID: HL54450 NHLBI NIH HHS, United States Grant ID: R01 HL054450 NIAID NIH HHS, United States Grant ID: R37 AI026791 NIGMS NIH HHS, United States Grant ID: T32 GM007205 NIAID NIH HHS, United States Grant ID: R01 AI026791 NIAID NIH HHS, United States Grant ID: AI26791 NIGMS NIH HHS, United States Grant ID: 5T32GM07205 More Less keyboard_arrow_down" @default.
- W4205396058 created "2022-01-26" @default.
- W4205396058 creator A5090268027 @default.
- W4205396058 date "2002-12-26" @default.
- W4205396058 modified "2023-09-28" @default.
- W4205396058 title "Faculty Opinions recommendation of Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen." @default.
- W4205396058 doi "https://doi.org/10.3410/f.1011039.177165" @default.
- W4205396058 hasPublicationYear "2002" @default.
- W4205396058 type Work @default.
- W4205396058 citedByCount "0" @default.
- W4205396058 crossrefType "dataset" @default.
- W4205396058 hasAuthorship W4205396058A5090268027 @default.
- W4205396058 hasBestOaLocation W42053960581 @default.
- W4205396058 hasConcept C100701293 @default.
- W4205396058 hasConcept C147483822 @default.
- W4205396058 hasConcept C203014093 @default.
- W4205396058 hasConcept C2776042228 @default.
- W4205396058 hasConcept C2776070231 @default.
- W4205396058 hasConcept C2776217527 @default.
- W4205396058 hasConcept C2778754761 @default.
- W4205396058 hasConcept C59822182 @default.
- W4205396058 hasConcept C71924100 @default.
- W4205396058 hasConcept C81444415 @default.
- W4205396058 hasConcept C86803240 @default.
- W4205396058 hasConcept C8891405 @default.
- W4205396058 hasConceptScore W4205396058C100701293 @default.
- W4205396058 hasConceptScore W4205396058C147483822 @default.
- W4205396058 hasConceptScore W4205396058C203014093 @default.
- W4205396058 hasConceptScore W4205396058C2776042228 @default.
- W4205396058 hasConceptScore W4205396058C2776070231 @default.
- W4205396058 hasConceptScore W4205396058C2776217527 @default.
- W4205396058 hasConceptScore W4205396058C2778754761 @default.
- W4205396058 hasConceptScore W4205396058C59822182 @default.
- W4205396058 hasConceptScore W4205396058C71924100 @default.
- W4205396058 hasConceptScore W4205396058C81444415 @default.
- W4205396058 hasConceptScore W4205396058C86803240 @default.
- W4205396058 hasConceptScore W4205396058C8891405 @default.
- W4205396058 hasLocation W42053960581 @default.
- W4205396058 hasOpenAccess W4205396058 @default.
- W4205396058 hasPrimaryLocation W42053960581 @default.
- W4205396058 hasRelatedWork W1583487173 @default.
- W4205396058 hasRelatedWork W1768409271 @default.
- W4205396058 hasRelatedWork W1992480592 @default.
- W4205396058 hasRelatedWork W2140862987 @default.
- W4205396058 hasRelatedWork W2166050584 @default.
- W4205396058 hasRelatedWork W2166849984 @default.
- W4205396058 hasRelatedWork W2399361780 @default.
- W4205396058 hasRelatedWork W2483178925 @default.
- W4205396058 hasRelatedWork W4313311434 @default.
- W4205396058 hasRelatedWork W953045247 @default.
- W4205396058 isParatext "false" @default.
- W4205396058 isRetracted "false" @default.
- W4205396058 workType "dataset" @default.